NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming into Intrahepatic Cholangiocarcinoma

YAP/TAZ functions and their regulation at a glance

(2020) Arianna Pocaterra et al.   JOURNAL OF CELL SCIENCE

Molecular targeted therapies: Ready for “prime time” in biliary tract cancer

(2020) Angela Lamarca et al.   JOURNAL OF HEPATOLOGY

Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration

(2019) Ximeng Han et al.   Stem Cell Reports

TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma

(2019) Jie Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Development of the Intrahepatic and Extrahepatic Biliary Tract: A Framework for Understanding Congenital Diseases

(2019) Frédéric P. Lemaigre   Annual Review of Pathology-Mechanisms of Disease

Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis

(2019) Jingxiao Wang et al.   JOURNAL OF HEPATOLOGY

Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns

(2019) Sungjin Ko et al.   Annual Review of Pathology-Mechanisms of Disease

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

(2019) Luigi Aloia et al.   NATURE CELL BIOLOGY

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

(2019) Iván M. Moya et al.   SCIENCE

Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans

(2018) Shanshan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Kras and Tp53 mutations cause cholangiocyte- and hepatocyte-derived cholangiocarcinoma

(2018) Margaret A Hill et al.   CANCER RESEARCH

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

(2018) Jingxiao Wang et al.   ONCOGENE

Cancer epigenetics: Moving forward

(2018) Angela Nebbioso et al.   PLoS Genetics

SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance

(2018) Xiaodong Yuan et al.   BRITISH JOURNAL OF CANCER

Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8

(2018) Sungjin Ko et al.   GASTROENTEROLOGY

Mouse Genome Database (MGD) 2019

(2018) Carol J Bult et al.   NUCLEIC ACIDS RESEARCH

NUAK2 is a critical YAP target in liver cancer

(2018) Wei-Chien Yuan et al.   Nature Communications

MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice

(2017) Zhang-Hui Chen et al.   GASTROENTEROLOGY

Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice

(2017) Junyan Tao et al.   HEPATOLOGY

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

(2017) Maite Merino-Azpitarte et al.   JOURNAL OF HEPATOLOGY

Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene

(2017) Zhang-Hui Chen et al.   NATURE BIOTECHNOLOGY

Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡

(2016) Kelly McDaniel et al.   HEPATOLOGY

Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape

(2016) Agata Page et al.   JOURNAL OF HEPATOLOGY

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

(2016) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Clinicopathological and prognostic significance of Yes-associated protein expression in hepatocellular carcinoma and hepatic cholangiocarcinoma

(2016) Hao Wu et al.   TUMOR BIOLOGY

The current management of cholangiocarcinoma: A comparison of current guidelines

(2016) Yulong Cai et al.   BioScience Trends

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

(2016) Da-Hye Lee et al.   Nature Communications

Dnmt1 regulates the myogenic lineage specification of muscle stem cells

(2016) Renjing Liu et al.   Scientific Reports

Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management

(2015) Sumera Rizvi et al.   Clinical Gastroenterology and Hepatology

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

(2015) Xinzhong Li et al.   Scientific Reports

DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status

(2015) Kazuaki Nakamura et al.   PLoS One

Second-line chemotherapy in advanced biliary cancer: a systematic review

(2014) A. Lamarca et al.   ANNALS OF ONCOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

KrasG12D and p53 Mutation Cause Primary Intrahepatic Cholangiocarcinoma

(2012) M. R. O'Dell et al.   CANCER RESEARCH

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

(2012) Augusto Villanueva et al.   GASTROENTEROLOGY

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma

(2012) Naoki Oishi et al.   HEPATOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

Nearest Template Prediction: A Single-Sample-Based Flexible Class Prediction with Confidence Assessment

(2010) Yujin Hoshida   PLoS One

Notch signaling controls liver development by regulating biliary differentiation

(2009) Y. Zong et al.   DEVELOPMENT

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY