Single-nucleus transcriptomic landscape of primate hippocampal aging

Assessing the Relationship Between Monoallelic PRKN Mutations and Parkinson’s Risk

(2021) Steven J Lubbe et al.   HUMAN MOLECULAR GENETICS

Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

(2021) Muhammad Khadeesh bin Imtiaz et al.   Cell Stem Cell

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

(2021) Marcel S. Woo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SIRT3 consolidates heterochromatin and counteracts senescence

(2021) Zhiqing Diao et al.   NUCLEIC ACIDS RESEARCH

Early stem cell aging in the mature brain

(2021) Albina Ibrayeva et al.   Cell Stem Cell

Decoding the development of the human hippocampus

(2020) Suijuan Zhong et al.   NATURE

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

(2020) Huifang Hu et al.   NUCLEIC ACIDS RESEARCH

A single-cell transcriptomic landscape of primate arterial aging

(2020) Weiqi Zhang et al.   Nature Communications

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

(2020) Chuqian Liang et al.   CELL RESEARCH

Aging and Rejuvenation of Neural Stem Cells and Their Niches

(2020) Paloma Navarro Negredo et al.   Cell Stem Cell

The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage

(2020) Hui-Chun Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physiological blood–brain transport is impaired with age by a shift in transcytosis

(2020) Andrew C. Yang et al.   NATURE

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

(2020) Shijia Bi et al.   Protein & Cell

A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging

(2020) Jingyi Li et al.   National Science Review

Single-cell transcriptomic atlas of primate cardiopulmonary aging

(2020) Shuai Ma et al.   CELL RESEARCH

Deciphering primate retinal aging at single-cell resolution

(2020) Si Wang et al.   Protein & Cell

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

(2020) Tracy A Bedrosian et al.   EMBO JOURNAL

Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

(2020) Wei-Na Jin et al.   NATURE NEUROSCIENCE

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

(2020) Sean X. Gu et al.   Nature Reviews Cardiology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

(2020) Kaifan Zhang et al.   Protein & Cell

SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data

(2020) Matthew D Young et al.   GigaScience

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Progenitors from the central nervous system drive neurogenesis in cancer

(2019) Philippe Mauffrey et al.   NATURE

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

(2019) Liping Deng et al.   Nature Communications

Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2

(2019) Heli Tiensuu et al.   PLoS Genetics

Low-dose quercetin positively regulates mouse healthspan

(2019) Lingling Geng et al.   Protein & Cell

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Variants in nuclear factor I genes influence growth and development

(2019) Martin Zenker et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

TREM2 triggers microglial density and age‐related neuronal loss

(2018) Bettina Linnartz‐Gerlach et al.   GLIA

Adult Hippocampal Neurogenesis: A Coming-of-Age Story

(2018) H. Georg Kuhn et al.   JOURNAL OF NEUROSCIENCE

Coaching from the sidelines: the nuclear periphery in genome regulation

(2018) Abigail Buchwalter et al.   NATURE REVIEWS GENETICS

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia

(2017) In Koo Hwang et al.   Molecular Medicine Reports

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Non-human primates as a model for aging

(2017) Ricki J. Colman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism

(2016) O. A. Marcos-Contreras et al.   BLOOD

The biological function and significance of CD74 in immune diseases

(2016) Huiting Su et al.   INFLAMMATION RESEARCH

Genome editing in nonhuman primates: approach to generating human disease models

(2016) Y. Chen et al.   JOURNAL OF INTERNAL MEDICINE

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

(2016) Suguna Rani Krishnaswami et al.   Nature Protocols

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons

(2016) Naomi Habib et al.   SCIENCE

Alzheimer's disease: An acquired neurodegenerative laminopathy

(2016) Bess Frost   Nucleus

Alzheimer's disease: An acquired neurodegenerative laminopathy

(2016) Bess Frost   Nucleus

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

(2015) Nora Bengoa-Vergniory et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Hopx distinguishes hippocampal from lateral ventricle neural stem cells

(2015) Deqiang Li et al.   Stem Cell Research

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations

(2014) Lachlan Harris et al.   DEVELOPMENTAL DYNAMICS

Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-dependent Cognitive Decline

(2014) Marlene J. Végh et al.   MOLECULAR & CELLULAR PROTEOMICS

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Regulation and Function of Adult Neurogenesis: From Genes to Cognition

(2014) James B. Aimone et al.   PHYSIOLOGICAL REVIEWS

Human tissue-type plasminogen activator

(2014) Egbert K. O. Kruithof et al.   THROMBOSIS AND HAEMOSTASIS

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks

(2012) Olga Rivero et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Evolution of hippocampal shapes across the human lifespan

(2012) Xianfeng Yang et al.   HUMAN BRAIN MAPPING

Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors

(2012) Yongchang Chen et al.   Journal of Genetics and Genomics

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Coagulation and the fibrin network in rheumatic disease: a role beyond haemostasis

(2012) Berthold Hoppe et al.   Nature Reviews Rheumatology

Abnormal Intracellular Accumulation and Extracellular Aβ Deposition in Idiopathic and Dup15q11.2-q13 Autism Spectrum Disorders

(2012) Jerzy Wegiel et al.   PLoS One

Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array

(2011) Geoffrey S. Baird et al.   AMERICAN JOURNAL OF PATHOLOGY

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Structure-Function Analysis of Nel, a Thrombospondin-1-like Glycoprotein Involved in Neural Development and Functions

(2011) Ritsuko Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chemorepellent Slit3 Promotes Monocyte Migration

(2010) S. B. Geutskens et al.   JOURNAL OF IMMUNOLOGY

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

The human brain in numbers: a linearly scaled-up primate brain

(2009) Suzana Herculano-Houzel   Frontiers in Human Neuroscience

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Aging hippocampus and amygdala

(2009) Nikolai V. Malykhin et al.   NEUROREPORT

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

(2008) Kathryn J Bryan et al.   Molecular Neurodegeneration