Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease

The impact on poisonings of up‐scheduling of modified release paracetamol to Schedule 3 (pharmacist only medicine)

(2023) Rose Cairns et al.   MEDICAL JOURNAL OF AUSTRALIA

Impact of Prior Drug Allergies on the Risk, Clinical Features, and Outcomes of Idiosyncratic Drug-Induced Liver Injury in Adults

(2022) Amoah Yeboah-Korang et al.   DIGESTIVE DISEASES AND SCIENCES

Impact of acetaminophen product labelling changes in Canada on hospital admissions for accidental acetaminophen overdose: a population-based study

(2022) Tony Antoniou et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015–2020

(2022) Ari B. Filip et al.   CLINICAL TOXICOLOGY

Self-poisonings before and during the initial year of the COVID-19 pandemic in northern Poland

(2022) Łukasz Sein Anand et al.   International Journal of Occupational Medicine and Environmental Health

Comparing characteristics of suicide to non-suicide drug poisoning deaths, by sex, in Ireland

(2022) Ena Lynn et al.   JOURNAL OF AFFECTIVE DISORDERS

The profile of patients presenting with intentional self-poisoning to the Charlotte Maxeke Johannesburg Academic Hospital emergency department, South Africa

(2022) A E Laher et al.   SAMJ SOUTH AFRICAN MEDICAL JOURNAL

Genetic variants associated with ALT elevation from therapeutic acetaminophen

(2022) Andrew A. Monte et al.   CLINICAL TOXICOLOGY

Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations

(2022) Daniel A. Spyker et al.   CLINICAL TOXICOLOGY

Comment on: “population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations”

(2022) A. L. Chiew et al.   CLINICAL TOXICOLOGY

Fomepizole should not be used more liberally in paracetamol overdose

(2022) James W. Dear   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis

(2022) Chun En Yau et al.   CLINICAL TOXICOLOGY

Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens

(2022) Slobodan M. Janković   Expert Opinion on Drug Metabolism & Toxicology

Extended Release Acetaminophen Overdose With Delayed Peak Concentrations

(2021) Avery Michienzi et al.   AMERICAN JOURNAL OF THERAPEUTICS

Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine

(2021) John W. Downs et al.   CLINICAL TOXICOLOGY

Coagulopathy, Bleeding Events and Outcome According to Rotational Thromboelastometry in Patients with Acute Liver Injury/Failure

(2021) RT Stravitz et al.   HEPATOLOGY

Utilization of a poison control center by critical access hospitals—one state’s experience

(2021) Connor Bowman et al.   CLINICAL TOXICOLOGY

The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews

(2021) Christina Abdel Shaheed et al.   MEDICAL JOURNAL OF AUSTRALIA

Paracetamol poisoning: a population-based study from Iceland

(2021) Þorbjörg Andrea Friðriksdóttir et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil

(2021) Genario Santos et al.   Annals of Hepatology

Exposures in pregnant patients reported to United States Poison Centers

(2021) James B. Leonard et al.   CLINICAL TOXICOLOGY

Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study

(2021) Jingyun Li et al.   CLINICAL TOXICOLOGY

Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record

(2021) Jeremy Louissaint et al.   DIGESTIVE DISEASES AND SCIENCES

Drug‐induced liver injury in Australia, 2009–2020: the increasing proportion of non‐paracetamol cases linked with herbal and dietary supplements

(2021) Emily Nash et al.   MEDICAL JOURNAL OF AUSTRALIA

Akute Intoxikationen auf der Intensivstation: Eine 10-Jahres-Analyse

(2021) Stephanie Siedler et al.   Medizinische Klinik-Intensivmedizin und Notfallmedizin

N-Acetylcysteine (NAC): Impacts on Human Health

(2021) Micaely Cristina dos Santos Tenório et al.   Antioxidants

Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System

(2021) Omid Mehrpour et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Acute drug poisonings leading to hospitalization

(2021) Charlotte Uggerhøj Andersen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Potential drug‐drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission

(2021) Beatrice Mainoli et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series

(2021) D. Nicholas Bateman et al.   CLINICAL TOXICOLOGY

Reply to Comments on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series

(2021) Stephanie L. Link et al.   CLINICAL TOXICOLOGY

Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series

(2021) Stephanie L. Link et al.   CLINICAL TOXICOLOGY

Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion

(2021) J. C. Lewis et al.   CLINICAL TOXICOLOGY

2020 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 38th Annual Report

(2021) David D. Gummin et al.   CLINICAL TOXICOLOGY

Toxico-epidemiology of acute poisoning; an exploratory study from a tertiary care hospital in South India along with global comparisons and solutions

(2021) Santhanu Jagannath Nair et al.   Journal of Forensic and Legal Medicine

Toxicological exposures reported to a telephonic consultation service at a tertiary care hospital in Lebanon

(2020) Eveline Hitti et al.   CLINICAL TOXICOLOGY

Characteristics of Drug-Induced Liver Injury in Northeast China: Disease Spectrum and Drug Types

(2020) Chong Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Utility of a Computerized ICD-10 Algorithm to Identify Idiosyncratic Drug-Induced Liver Injury Cases in the Electronic Medical Record

(2020) Amoah Yeboah-Korang et al.   DRUG SAFETY

Restriction of non-opioid analgesics sold over-the-counter in Denmark: a national study of impact on poisonings

(2020) Britt Reuter Morthorst et al.   JOURNAL OF AFFECTIVE DISORDERS

Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China

(2020) Yao Liu et al.   MEDICAL SCIENCE MONITOR

Drug induced liver injury is associated with high mortality—A study from a tertiary care hospital in Pakistan

(2020) Adeel Abid et al.   PLoS One

Accidental poisoning, intentional self-harm and event of undetermined intent mortality over 20 years in Iceland: a population-based cohort study

(2020) Oddny Sigurborg Gunnarsdottir et al.   BMJ Open

At-a-glance - Trends in emergency department visits for acetaminophen-related poisonings: 2011–2019

(2020) Jaskiran Kaur et al.   Health Promotion and Chronic Disease Prevention in Canada-Research Policy and Practice

Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review

(2020) Michael E. Mullins et al.   CLINICAL TOXICOLOGY

Evidence of drug-induced hepatotoxicity in the Maghrebian population

(2020) Mohammed Bourhia et al.   DRUG AND CHEMICAL TOXICOLOGY

Enquiries to the New Zealand National Poisons Centre in 2018

(2020) Eeva‐Katri Kumpula et al.   Emergency Medicine Australasia

Hospital referrals of patients with acute poisoning by the Belgian Poison Centre: analysis of characteristics, associated factors, compliance and costs

(2020) Anne-Marie Katrien Descamps et al.   EMERGENCY MEDICINE JOURNAL

A mitochondrial journey through acetaminophen hepatotoxicity

(2020) Anup Ramachandran et al.   FOOD AND CHEMICAL TOXICOLOGY

Suicide‐related over‐the‐counter analgesic exposures reported to United States poison control centers, 2000‐2018

(2020) Alexandra G. Hopkins et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Novel strategies for the treatment of acetaminophen hepatotoxicity

(2020) Jephte Y. Akakpo et al.   Expert Opinion on Drug Metabolism & Toxicology

A 9-year retrospective study of poisoning-related deaths in Southwest China (Sichuan)

(2020) Li Xiao et al.   FORENSIC SCIENCE INTERNATIONAL

2019 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 37th Annual Report

(2020) David D. Gummin et al.   CLINICAL TOXICOLOGY

Acute liver injury with therapeutic doses of acetaminophen: a prospective study

(2020) Alexandre Louvet et al.   HEPATOLOGY

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

(2019) Jephte Y Akakpo et al.   TOXICOLOGICAL SCIENCES

Availability of drug at convenient stores is not associated with an increased incidence of their poisoning

(2019) Kwang Yul Jung et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol

(2019) Harry Egan et al.   CLINICAL TOXICOLOGY

A quarter of admitted poisoned patients have a mild poisoning and require no treatment: An observational study

(2019) Laura Hondebrink et al.   European Journal of Internal Medicine

Old problem, new solutions: biomarker discovery for acetaminophen liver toxicity

(2019) Yvonne Gloor et al.   Expert Opinion on Drug Metabolism & Toxicology

Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial)

(2019) Emma E. Morrison et al.   EBioMedicine

Paracetamol poisoning‐related hospital admissions and deaths in Australia, 2004–2017

(2019) Rose Cairns et al.   MEDICAL JOURNAL OF AUSTRALIA

Acetaminophen poisonings hospitalized at the Pomeranian Center Of Toxicology in 2010−2015

(2019) Bartłomiej Garczewski et al.   MEDYCYNA PRACY

Sex differences in patients with suicidal intent that are managed by toxicologists

(2019) Gillian A. Beauchamp et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Fatalities in poisoned patients managed by medical toxicologists

(2019) Nir Friedman et al.   CLINICAL TOXICOLOGY

2018 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 36th Annual Report

(2019) David D. Gummin et al.   CLINICAL TOXICOLOGY

Early Acetaminophen-Protein Adducts Predict Hepatotoxicity Following Overdose

(2019) Angela L. Chiew et al.   JOURNAL OF HEPATOLOGY

Characteristics and costs in adults with acute poisoning admitted to the emergency department of a university hospital in Belgium

(2019) Anne-Marie K. Descamps et al.   PLoS One

Temporal trends in incidence of hospital-treated self-harm among adolescents in Denmark: national register-based study

(2019) Sarah Steeg et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

In vitro study of pharmacobezoar formation in simulated acetaminophen overdose

(2019) Yu Kwan Li et al.   CLINICAL TOXICOLOGY

Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand

(2019) Angela L Chiew et al.   MEDICAL JOURNAL OF AUSTRALIA

Availability of Paracetamol Sold Over the Counter in Europe: A Descriptive Cross-Sectional International Survey of Pack Size Restriction

(2018) Britt Reuter Morthorst et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study

(2018) Yu-Ting Chung et al.   Cardiovascular Toxicology

Modified release paracetamol overdose: a prospective observational study (ATOM-3)

(2018) Angela L. Chiew et al.   CLINICAL TOXICOLOGY

Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose

(2018) Lars E. Schmidt et al.   CLINICAL TOXICOLOGY

Underreporting of fatal poisonings in Brazil – A descriptive study using data from four information systems

(2018) Andrea Franco Amoras Magalhães et al.   FORENSIC SCIENCE INTERNATIONAL

Two health information systems to characterize poisoning in Brazil—a descriptive study

(2018) Andrea Franco Amoras Magalhães et al.   JOURNAL OF PUBLIC HEALTH

Patterns of poisoning exposure at different ages: the 2015 annual report of the Australian Poisons Information Centres

(2018) Alanna Huynh et al.   MEDICAL JOURNAL OF AUSTRALIA

Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan

(2018) Hung-Sheng Huang et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

(2018) Anna Moles et al.   Frontiers in Pharmacology

Factors associated with hospitalization after self-poisoning in France: special focus on the impact of alcohol use disorder

(2018) Juliette Salles et al.   BMC Psychiatry

Sex Differences in Poisonings Among Older Adults: An Analysis of the Toxicology Investigators Consortium (ToxIC) Registry, 2010 to 2016

(2018) Gillian A. Beauchamp et al.   CLINICAL THERAPEUTICS

Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity

(2018) Daniel P. Heruth et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acute poisoning in Shenyang, China: a retrospective and descriptive study from 2012 to 2016

(2018) Yajie Zhang et al.   BMJ Open

2017 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 35th Annual Report

(2018) David D. Gummin et al.   CLINICAL TOXICOLOGY

Potential pharmacobezoar formation of large size extended-release tablets and their dissolution – an in vitro study

(2018) Lotte Christine Groth Hoegberg et al.   CLINICAL TOXICOLOGY

Acute poisonings in Croatia: differences in epidemiology, associated comorbidities and final outcomes – a single-centre 15-year follow-up

(2018) Iva Klobučar et al.   CLINICAL TOXICOLOGY

Low Serum Hepcidin is Associated with Reduced Short-term Survival in Adults with Acute Liver Failure

(2018) Igor Spivak et al.   HEPATOLOGY

Pattern of suicide by self-poisoning in Northern Tunisia: An eleven-year study (2005–2015)

(2018) Meriem Gharbaoui et al.   Journal of Forensic and Legal Medicine

Elevated procalcitonin is associated with bacterial infection during acute liver failure only when unrelated to acetaminophen intoxication

(2017) Maxime Mallet et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Framskyggn rannsókn á eitrunum sem komu til meðferðar á bráðamóttökum Landspítala 2012

(2017) Guðborg Auður Guðjónsdóttir et al.   Laeknabladid

Self-poisoning by older Australians: a cohort study

(2017) Peter I Pillans et al.   MEDICAL JOURNAL OF AUSTRALIA

Development and validation of a risk-prediction nomogram for in-hospital mortality in adults poisoned with drugs and nonpharmaceutical agents

(2017) Catalina Lionte et al.   MEDICINE

Increased availability of paracetamol in Sweden and incidence of paracetamol poisoning: using laboratory data to increase validity of a population-based registry study

(2017) Rolf Gedeborg et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Unintentional and self-poisoning mortalities in Mexico, 2000–2012

(2017) Omar González-Santiago et al.   PLoS One

Acute poisonings during pregnancy and in other non-pregnant women in emergency departments of four government hospitals, Addis Ababa, Ethiopia: 2010-2015

(2017) Mebrahtu Eyasu et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Do pre-hospital poisoning deaths differ from in-hospital deaths? A retrospective analysis

(2017) Lauri Koskela et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Fatal poisonings in Northern Finland: causes, incidence, and rural-urban differences

(2017) Lauri Koskela et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Adverse drug events—Analysis of a decade. A Portuguese case-study, from 2004 to 2013 using hospital database

(2017) Gianina Scripcaru et al.   PLoS One

Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia

(2016) J. K. Moore et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Hepatotoxicity in Obese Versus Nonobese Patients With Acetaminophen Poisoning Who Are Treated With Intravenous N-Acetylcysteine

(2016) John J. Radosevich et al.   AMERICAN JOURNAL OF THERAPEUTICS

Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases

(2016) Paul Acheampong et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury

(2016) ADB Vliegenthart et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study

(2016) Phillip Molloy et al.   BMJ Open

Emergency department visits for attempted suicide and self harm in the USA: 2006–2013

(2016) J. K. Canner et al.   Epidemiology and Psychiatric Sciences

Liver transplant associated with paracetamol overdose: results from the seven-country SALT study

(2015) Sinem Ezgi Gulmez et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)?

(2015) Michael G. Leeming et al.   CHEMICAL RESEARCH IN TOXICOLOGY

External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose

(2015) Anselm Wong et al.   CLINICAL TOXICOLOGY

Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions

(2015) Anselm Wong et al.   CLINICAL TOXICOLOGY

A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose

(2015) R. Mason Curtis et al.   CLINICAL TOXICOLOGY

Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment

(2014) D. Nicholas Bateman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio

(2014) Katie H Owens et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: The recent United Kingdom experience

(2014) D. N. Bateman et al.   CLINICAL TOXICOLOGY

Acetaminophen/paracetamol: A history of errors, failures and false decisions

(2014) K. Brune et al.   EUROPEAN JOURNAL OF PAIN

Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease

(2014) Anaïs Michaut et al.   LIVER INTERNATIONAL

Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges

(2014) James W Dear et al.   Expert Review of Clinical Pharmacology

Treating acetaminophen overdose: thresholds, costs and uncertainties

(2013) S. Gosselin et al.   CLINICAL TOXICOLOGY

Acetaminophen-related Hepatotoxicity

(2013) Chalermrat Bunchorntavakul et al.   Clinics in Liver Disease

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Timing and benefit of liver transplantation in acute liver failure

(2013) John O’Grady   JOURNAL OF HEPATOLOGY

Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses

(2013) K. Hawton et al.   BMJ-British Medical Journal

The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

(2013) Garry G. Graham et al.   INFLAMMOPHARMACOLOGY

A Review of Acetaminophen Poisoning

(2012) Michael J. Hodgman et al.   CRITICAL CARE CLINICS

Evaluation of a Simplified N-Acetylcysteine Dosing Regimen for the Treatment of Acetaminophen Toxicity

(2011) Michael T Johnson et al.   ANNALS OF PHARMACOTHERAPY

Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity

(2011) Darren G. N. Craig et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Clinical course of repeated supratherapeutic ingestion of acetaminophen

(2011) Mohammed A. Alhelail et al.   CLINICAL TOXICOLOGY

Dental pain as a risk factor for accidental acetaminophen overdose: a case-control study

(2010) Jody Vogel et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration

(2010) Timothy J. Wiegand et al.   CLINICAL TOXICOLOGY

When do the aminotransferases rise after acute acetaminophen overdose?

(2010) Thomas J. Green et al.   CLINICAL TOXICOLOGY

Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose

(2010) Marco L.A. Sivilotti et al.   CLINICAL TOXICOLOGY

Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol

(2010) A. Graudins et al.   INTERNAL MEDICINE JOURNAL

Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase

(2010) R. Agarwal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

(2009) L. P. James et al.   DRUG METABOLISM AND DISPOSITION

Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity

(2009) Robert P. Myers et al.   HEPATOLOGY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Delayed onset of acute renal failure after significant paracetamol overdose: A case series

(2009) WS Waring et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Acute Ethanol Coingestion Confers a Lower Risk of Hepatotoxicity after Deliberate Acetaminophen Overdose

(2008) W. Stephen Waring et al.   ACADEMIC EMERGENCY MEDICINE

Impact of Liver Disease, Alcohol Abuse, and Unintentional Ingestions on the Outcomes of Acetaminophen Overdose

(2008) R MYERS et al.   Clinical Gastroenterology and Hepatology

Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: A nationwide analysis

(2008) Geoffrey C. Nguyen et al.   HEPATOLOGY

Paracetamol (Acetaminophen): mechanisms of action

(2008) BRIAN J. ANDERSON   PEDIATRIC ANESTHESIA

Evidence and consequences of spectrum bias in studies of criteria for liver transplant in paracetamol hepatotoxicity

(2008) G.K.A. Ding et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning

(2003) L. E. Schmidt et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY