Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges

Are we closer to finding biomarkers for identifying acute drug-induced liver injury?

(2013) Daniel J Antoine et al.   Biomarkers in Medicine

Treating acetaminophen overdose: thresholds, costs and uncertainties

(2013) S. Gosselin et al.   CLINICAL TOXICOLOGY

Character and Temporal Evolution of Apoptosis in Acetaminophen-Induced Acute Liver Failure*

(2013) Lucia A. Possamai et al.   CRITICAL CARE MEDICINE

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations

(2013) Zev Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose

(2013) K. Al-Hourani et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses

(2013) K. Hawton et al.   BMJ-British Medical Journal

Statistical challenges in the development and evaluation of marker-based clinical tests

(2012) Lisa M McShane   BMC Medicine

Serum microRNA Biomarkers for Drug-Induced Liver Injury

(2012) P J Starkey Lewis et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Alanine Aminotransferase: A Clinical and Regulatory Tool for Detecting Liver Injury–Past, Present, and Future

(2012) J R Senior   CLINICAL PHARMACOLOGY & THERAPEUTICS

Investigative safety science as a competitive advantage for Pharma

(2012) Jonathan Moggs et al.   Expert Opinion on Drug Metabolism & Toxicology

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning

(2012) W Stephen Waring   Expert Review of Clinical Pharmacology

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

A generic operational strategy to qualify translational safety biomarkers

(2011) Katja Matheis et al.   DRUG DISCOVERY TODAY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

(2011) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

When do the aminotransferases rise after acute acetaminophen overdose?

(2010) Thomas J. Green et al.   CLINICAL TOXICOLOGY

Detailed analyses of self-poisoning episodes presenting to a large regional teaching hospital in the UK

(2009) Katherine Prescott et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose

(2009) W. Stephen Waring et al.   CLINICAL TOXICOLOGY

Acetaminophen protein adducts: A review

(2009) G. Randall Bond   CLINICAL TOXICOLOGY

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress

(2009) D.J. Antoine et al.   XENOBIOTICA

Biomarker method validation in anticancer drug development

(2007) J Cummings et al.   BRITISH JOURNAL OF PHARMACOLOGY