The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
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Title
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
Authors
Keywords
Paracetamol, Acetaminophen, Pain, Analgesia, Inflammation, Prostaglandin, Thromboxane, Prostacyclin, Cyclooxygenase, COX-1, COX-2, COX-3, Myeloperoxidase, Atherosclerosis, Peroxidase, MIF, Diabetes, rhabdomyolysis, Resveratrol
Journal
INFLAMMOPHARMACOLOGY
Volume 21, Issue 3, Pages 201-232
Publisher
Springer Nature
Online
2013-05-30
DOI
10.1007/s10787-013-0172-x
References
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Note: Only part of the references are listed.- Acetaminophen and Asthma: Spurious Association?
- (2013) Kwok Chiu Chang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Can Intravenous Paracetamol Reduce Opioid Use in Preoperative Hip Fracture Patients?
- (2013) Kai S. Tsang et al. ORTHOPEDICS
- Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses
- (2013) K. Hawton et al. BMJ-British Medical Journal
- Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension
- (2012) Hisham Aljadhey et al. BMC Cardiovascular Disorders
- Use of Nonsteroidal Anti-inflammatory Drugs and Risk of Ovarian and Endometrial Cancer: The Multiethnic Cohort
- (2012) V. W. Setiawan et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Nonsteroidal Antiinflammatory Drugs, Acetaminophen, and Hypertension
- (2012) Isabella Sudano et al. CURRENT HYPERTENSION REPORTS
- Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study
- (2012) Nicholas Mohr et al. Internal and Emergency Medicine
- American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
- (2012) Marc C. Hochberg et al. ARTHRITIS CARE & RESEARCH
- Effects of high-dose paracetamol on blood pressure in acute stroke
- (2011) H. M. den Hertog et al. ACTA NEUROLOGICA SCANDINAVICA
- Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
- (2011) Burkhard Hinz et al. ANNALS OF THE RHEUMATIC DISEASES
- A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain
- (2011) M. Doherty et al. ANNALS OF THE RHEUMATIC DISEASES
- Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review
- (2011) E Maund et al. BRITISH JOURNAL OF ANAESTHESIA
- A Large Cohort Study of Long-term Acetaminophen Use and Prostate Cancer Incidence
- (2011) E. J. Jacobs et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics
- (2011) L. M. Howells et al. Cancer Prevention Research
- The Effects of Nonsteroidal Anti-Inflammatory Drugs on Blood Pressure in Hypertensive Patients
- (2011) Stanley Snowden et al. Cardiology in Review
- Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis
- (2011) S. Eyers et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Opioid-Paracetamol Prescription Patterns and Liver Dysfunction
- (2011) Jane R. Mort et al. DRUG SAFETY
- High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase
- (2011) Philip E. Morgan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Tropisetron and paracetamol association in post-operative patients
- (2011) Gisèle Pickering et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Influence of acetaminophen and ibuprofen on in vivo patellar tendon adaptations to knee extensor resistance exercise in older adults
- (2011) C. C. Carroll et al. JOURNAL OF APPLIED PHYSIOLOGY
- (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2
- (2011) Kelsey C Duggan et al. Nature Chemical Biology
- Tropisetron blocks analgesic action of acetaminophen: A human pain model study
- (2011) Oliver Bandschapp et al. PAIN
- A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain
- (2011) Stephen E. Daniels et al. PAIN
- Osteopontin Expression during Early Cerebral Ischemia-Reperfusion in Rats: Enhanced Expression in the Right Cortex Is Suppressed by Acetaminophen
- (2011) Sunanda S. Baliga et al. PLoS One
- Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
- (2011) D. K. Nomura et al. SCIENCE
- The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
- (2010) R. C. Dart et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults
- (2010) Todd A. Trappe et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Acetaminophen Use and Risk of Asthma, Rhinoconjunctivitis, and Eczema in Adolescents
- (2010) Richard W. Beasley et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The Comparative Safety of Analgesics in Older Adults With Arthritis
- (2010) Daniel H. Solomon ARCHIVES OF INTERNAL MEDICINE
- The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
- (2010) Amanda E. Lane et al. BIOCHEMICAL JOURNAL
- Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats
- (2010) Sunanda S. Baliga et al. BRAIN RESEARCH
- Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity
- (2010) Darren G. N. Craig et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease
- (2010) Isabella Sudano et al. CIRCULATION
- The Influence of Ondansetron on the Analgesic Effect of Acetaminophen After Laparoscopic Hysterectomy
- (2010) R Jokela et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans
- (2010) J H Winnike et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Fish oil supplementation increases the cyclooxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients
- (2010) Gillian E. Caughey et al. COMPLEMENTARY THERAPIES IN MEDICINE
- Study designs in paediatric pharmacoepidemiology
- (2010) Katia Verhamme et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Paracetamol for intravenous use in medium- and intensive care patients: pharmacokinetics and tolerance
- (2010) Monique M. de Maat et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents
- (2010) Romina Nassini et al. FASEB JOURNAL
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- (2010) Olivier Boutaud et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2010) Samir S. Ayoub et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
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- (2010) H G Shertzer et al. INTERNATIONAL JOURNAL OF OBESITY
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- (2010) Katherine J. Bryant et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Michael J. Davies JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty
- (2010) S. J. Mitchell et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
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- (2010) Hazel Palmer et al. PAIN MEDICINE
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- (2010) O. Boutaud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link
- (2010) H. Conroy et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- A Literature Review of Randomized Clinical Trials of Intravenous Acetaminophen (Paracetamol) for Acute Postoperative Pain
- (2010) Alex Macario et al. Pain Practice
- FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
- (2010) Garry G. Graham et al. INFLAMMOPHARMACOLOGY
- Mechanisms of Non-Opioid Analgesics Beyond Cyclooxygenase Enzyme Inhibition
- (2010) May Hamza et al. Current Molecular Pharmacology
- The Effects of Intrathecal Cyclooxygenase-1, Cyclooxygenase-2, or Nonselective Inhibitors on Pain Behavior and Spinal Fos-Like Immunoreactivity
- (2009) Il Ok Lee et al. ANESTHESIA AND ANALGESIA
- Interventional Pain Treatments for Cancer Pain
- (2009) Paul J. Christo et al. Annals of the New York Academy of Sciences
- Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease
- (2009) Betty S. van der Veen et al. ANTIOXIDANTS & REDOX SIGNALING
- Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione
- (2009) Valdecir F. Ximenes et al. BIOCHEMICAL JOURNAL
- Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations
- (2009) Maud Koelsch et al. BIOCHEMICAL PHARMACOLOGY
- Acetaminophen Use and the Risk of Asthma in Children and Adults
- (2009) Mahyar Etminan et al. CHEST
- Evaluation of analgesic efficacy, gastrotoxicity and nephrotoxicity of fixed-dose combinations of nonselective, preferential and selective cyclooxgenase inhibitors with paracetamol in rats
- (2009) Gaurav Kumar et al. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
- Use of acetaminophen during pregnancy and risk of preeclampsia, hypertensive and vascular disorders: A birth cohort study
- (2009) Cristina Rebordosa et al. Journal of Maternal-Fetal & Neonatal Medicine
- Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress
- (2009) Debjani Tripathy et al. Journal of Neuroinflammation
- Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells
- (2009) Lena Wendeburg et al. Journal of Neuroinflammation
- Acetaminophen, aspirin and progression of advanced chronic kidney disease
- (2009) M. Evans et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
- (2009) Sudhir N. Umathe et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control
- (2009) Buket Tasmacioglu et al. SUPPORTIVE CARE IN CANCER
- Analgesic effect of paracetamol on cancer related pain in concurrent strong opioid therapy. A prospective clinical study
- (2008) Bertil Axelsson et al. ACTA ONCOLOGICA
- The Antiplatelet Effect of Six Non-Steroidal Anti-Inflammatory Drugs and Their Pharmacodynamic Interaction With Aspirin in Healthy Volunteers
- (2008) Patrick A. Gladding et al. AMERICAN JOURNAL OF CARDIOLOGY
- Hospitalizations for Upper and Lower GI Events Associated With Traditional NSAIDs and Acetaminophen Among the Elderly in Quebec, Canada
- (2008) Elham Rahme et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications
- (2008) Michael J. Davies et al. ANTIOXIDANTS & REDOX SIGNALING
- Protective effect of resveratrol in endotoxemia-induced acute phase response in rats
- (2008) Hichem Sebai et al. ARCHIVES OF TOXICOLOGY
- Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid
- (2008) Mitchell M. Lloyd et al. BIOCHEMICAL JOURNAL
- Hypobromous acid and bromamine production by neutrophils and modulation by superoxide
- (2008) Anna L. P. Chapman et al. BIOCHEMICAL JOURNAL
- Acetaminophen normalizes glucose homeostasis in mouse models for diabetes
- (2008) Howard G. Shertzer et al. BIOCHEMICAL PHARMACOLOGY
- Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet
- (2008) Eric L. Kendig et al. BIOCHEMICAL PHARMACOLOGY
- Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor Active Site Interactions†‡
- (2008) Gregg V. Crichlow et al. BIOCHEMISTRY
- Preventive Effects of Nutritional Doses of Polyphenolic Molecules on Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of Osteopontin and Oxidative Stress
- (2008) Thibault Sutra et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- The role of non-steroidal anti-inflammatory drugs in the risk of development and treatment of hematologic malignancies
- (2008) Pawel Robak et al. LEUKEMIA & LYMPHOMA
- Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl-phenolamine (AM404) in the rat: comparison with paracetamol
- (2008) Valentina Ruggieri et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Acetaminophen prevents hyperalgesia in central pain cascade
- (2008) Brianna Crawley et al. NEUROSCIENCE LETTERS
- Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia
- (2008) Christophe Mallet et al. PAIN
- The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products
- (2008) D.F. Woodward et al. PHARMACOLOGY & THERAPEUTICS
- The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models
- (2008) Y SEO et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Effect of Intravenous Propacetamol on Blood Pressure in Febrile Critically Ill Patients
- (2008) Moshe Hersch et al. PHARMACOTHERAPY
- COX-2 Selective Inhibitors in the Treatment of Osteoarthritis
- (2008) Loren Laine et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite
- (2007) Stefan Schildknecht et al. FASEB JOURNAL
- Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
- (2007) Burkhard Hinz et al. FASEB JOURNAL
- Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain
- (2007) H MIRANDA et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Acetaminophen: Antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant
- (2007) Shuxin Li et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
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