Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review

Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure

(2020) Hartmut Jaeschke et al.   TOXICOLOGICAL SCIENCES

Fomepizole as an adjunctive treatment in severe acetaminophen ingestions: a case series

(2020) Kartik R. Shah et al.   CLINICAL TOXICOLOGY

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

(2019) Jephte Y Akakpo et al.   TOXICOLOGICAL SCIENCES

What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?

(2019) Robert G. Hendrickson   CLINICAL TOXICOLOGY

Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial)

(2019) Emma E. Morrison et al.   EBioMedicine

Fomepizole as an adjunctive treatment in severe acetaminophen toxicity: A case report

(2019) Kartik R. Shah et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose

(2019) Jordan A. Woolum et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

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(2019) Daniel Colon Hidalgo et al.   CRITICAL CARE MEDICINE

The role of apoptosis in acetaminophen hepatotoxicity

(2018) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives

(2018) Anup Ramachandran et al.   GENE EXPRESSION

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

(2018) JY Akakpo et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

(2018) Mingzhu Yan et al.   Redox Biology

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

(2018) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Protective Effect of Carvedilol on Paracetamol-induced Hepatotoxicity; Role of Modulation Inflammation and Lipid Peroxidation

(2017) Heba M. Mahmoud et al.   International Journal of Pharmacology

Mangafodipir a Selective Cytoprotectant — with Special Reference to Oxaliplatin and Its Association to Chemotherapy-Induced Peripheral Neuropathy (CIPN)

(2017) Jan Olof G. Karlsson et al.   Translational Oncology

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Potential adjunct treatment for high-risk acetaminophen overdose

(2016) Luke Yip et al.   CLINICAL TOXICOLOGY

The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice

(2016) Seyed Soheil Saeedi Saravi et al.   PHARMACEUTICAL BIOLOGY

Editor’s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction

(2016) Kuo Du et al.   TOXICOLOGICAL SCIENCES

Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice

(2015) Yong-Hoon Kim et al.   JOURNAL OF HEPATOLOGY

Extracorporeal treatment for acetaminophen poisoning: Recommendations from the EXTRIP workgroup

(2014) S. Gosselin et al.   CLINICAL TOXICOLOGY

Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury

(2014) Kang Kwang Lee et al.   HEPATOLOGY

Up-regulation of nuclear related factor 2 (NRF2) and antioxidant responsive elements by metformin protects hepatocytes against the acetaminophen toxicity

(2014) Rajesh Ramachandran et al.   Toxicology Research

Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice

(2013) Mariel R. B. Betto et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A Gargantuan Acetaminophen Level in an Acidemic Patient Treated Solely With Intravenous N-Acetylcysteine

(2011) Michele Zell-Kanter et al.   AMERICAN JOURNAL OF THERAPEUTICS

Manganese Superoxide Dismutase: Guardian of the Powerhouse

(2011) Aaron K. Holley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables

(2011) Gordon Guyatt et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase

(2010) R. Agarwal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oral administration of fomepizole produces similar blood levels as identical intravenous dose

(2009) Jeanna Marraffa et al.   CLINICAL TOXICOLOGY

Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum

(2009) Athina Zira et al.   JOURNAL OF APPLIED TOXICOLOGY

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE