Evaluating physiochemical properties of FDA-approved orally administered drugs
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Evaluating physiochemical properties of FDA-approved orally administered drugs
Authors
Keywords
-
Journal
Expert Opinion on Drug Discovery
Volume -, Issue -, Pages 1-14
Publisher
Informa UK Limited
Online
2023-11-03
DOI
10.1080/17460441.2023.2275617
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
- (2023) Keith R. Hornberger et al. Journal of Medicinal Chemistry
- The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance
- (2023) Christopher E. Keefer et al. MOLECULAR PHARMACEUTICS
- Structural modification aimed for improving solubility of lead compounds in early phase drug discovery
- (2022) Bhanuranjan Das et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Approaches to minimize the effects of P‐glycoprotein in drug transport: A review
- (2022) Athar Husain et al. DRUG DEVELOPMENT RESEARCH
- Phase 1/2 study of ARV-110, an androgen receptor (AR) PROTAC degrader, in metastatic castration-resistant prostate cancer (mCRPC).
- (2022) Xin Gao et al. JOURNAL OF CLINICAL ONCOLOGY
- New Generation Gepants: Migraine Acute and Preventive Medications
- (2022) David Moreno-Ajona et al. Journal of Clinical Medicine
- Prediction of the Contribution Ratio of a Target Metabolic Enzyme to Clearance from Chemical Structure Information
- (2022) Reiko Watanabe et al. Molecular Pharmaceutics
- Prediction of total drug clearance in humans using animal data: proposal of a multimodal learning method based on deep learning
- (2021) Hiroaki Iwata et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions
- (2021) Dean G. Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- Advances in Oral Drug Delivery
- (2021) Mohammed S. Alqahtani et al. Frontiers in Pharmacology
- Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies
- (2021) Paul D. Leeson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation
- (2021) David J. Brayden et al. Expert Opinion on Drug Delivery
- Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
- (2021) Sonal V. Bhujbal et al. Acta Pharmaceutica Sinica B
- Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability
- (2021) Thi-Thao-Linh Nguyen et al. Pharmaceutics
- Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs
- (2020) Mulazim Hussain Asim et al. ACS Applied Materials & Interfaces
- Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting
- (2020) Anne-Sophie Wattiez et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Facts, Patterns and Principles in Drug Discovery: appraising the Rule of 5 with measured physicochemical data.
- (2020) Christopher P. Tinworth et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability
- (2020) Jannes van der Merwe et al. Pharmaceutics
- Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors
- (2020) Nicholas Barlow et al. ACS Chemical Biology
- Oral tablet formulations containing cyclodextrin complexes of poorly water soluble cefdinir to enhance its bioavailability
- (2020) Deniz Morina et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine
- (2020) Sarah J. Bucknell et al. JOURNAL OF MEDICINAL CHEMISTRY
- First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo
- (2020) Mingming Wei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Safety, tolerability, and efficacy of orally administered atogepant for the prevention of episodic migraine in adults: a double-blind, randomised phase 2b/3 trial
- (2020) Peter J Goadsby et al. LANCET NEUROLOGY
- Analyzing FDA-approved drugs for compliance of pharmacokinetic principles: should there be a critical screening parameter in drug designing protocols?
- (2020) Shelly Pathania et al. Expert Opinion on Drug Metabolism & Toxicology
- Solution Conformations Shed Light on PROTAC Cell Permeability
- (2020) Yoseph Atilaw et al. ACS Medicinal Chemistry Letters
- Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
- (2019) Sam Maher et al. Pharmaceutics
- Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges
- (2019) Scott D. Edmondson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls
- (2019) Katharina Kamm et al. CEPHALALGIA
- Targeting CGRP for the Prevention of Migraine and Cluster Headache: A Narrative Review
- (2019) Hsiangkuo Yuan et al. HEADACHE
- Why Some Targets Benefit from beyond Rule of Five Drugs
- (2019) Megan Egbert et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cyclodextrins as excipients in tablet formulations
- (2018) Jaime Conceição et al. DRUG DISCOVERY TODAY
- Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs
- (2018) Sonja Bonengel et al. JOURNAL OF CONTROLLED RELEASE
- Applications of nanoparticle systems in drug delivery technology
- (2018) Syed A.A. Rizvi et al. SAUDI PHARMACEUTICAL JOURNAL
- The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
- (2018) Li Zhang et al. Drug Design Development and Therapy
- Avatrombopag, an oral thrombopoietin receptor agonist: results of two double-blind, dose-rising, placebo-controlled Phase 1 studies
- (2018) David J. Kuter et al. BRITISH JOURNAL OF HAEMATOLOGY
- Emerging advances in P-glycoprotein inhibitory nanomaterials for drug delivery
- (2018) Longfa Kou et al. Expert Opinion on Drug Delivery
- Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs
- (2018) Michael D. Shultz JOURNAL OF MEDICINAL CHEMISTRY
- Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches - a PEARRL review
- (2018) Felix Ditzinger et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs
- (2018) Sainan An et al. EBioMedicine
- PEPT1-mediated prodrug strategy for oral delivery of peramivir
- (2018) Yongbing Sun et al. Asian Journal of Pharmaceutical Sciences
- Prodrug approach: An overview of recent cases
- (2017) Valentina Abet et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes
- (2017) Melanie Davies et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- BCS class IV drugs: Highly notorious candidates for formulation development
- (2017) Rohan Ghadi et al. JOURNAL OF CONTROLLED RELEASE
- Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
- (2017) David A. DeGoey et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules
- (2017) Cameron R. Pye et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dual Modulation of Human P-Glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood–Brain Barrier
- (2017) Kelsey Bohn et al. MOLECULAR PHARMACEUTICS
- Log P , a yesterday's value?
- (2017) Chrysoula Vraka et al. NUCLEAR MEDICINE AND BIOLOGY
- Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy
- (2017) Yanxia Gong et al. Oncotarget
- Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir
- (2017) Saleha Rehman et al. Biomed Research International
- BDDCS, the Rule of 5 and drugability
- (2016) Leslie Z. Benet et al. ADVANCED DRUG DELIVERY REVIEWS
- Understanding the Challenge of Beyond-Rule-of-5 Compounds
- (2016) Christel A.S. Bergström et al. ADVANCED DRUG DELIVERY REVIEWS
- In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1
- (2016) Y. Anne Pak et al. DRUG METABOLISM AND DISPOSITION
- Methodology of oral formulation selection in the pharmaceutical industry
- (2016) Martin Kuentz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Formulation of cyclodextrin inclusion complex-based orally disintegrating tablet of eslicarbazepine acetate for improved oral bioavailability
- (2016) Samixa Desai et al. Materials Science & Engineering C-Materials for Biological Applications
- Structural and conformational determinants of macrocycle cell permeability
- (2016) Björn Over et al. Nature Chemical Biology
- High-Throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals
- (2016) Jeffrey M. Ting et al. ACS Central Science
- Nanomilling of Drugs for Bioavailability Enhancement: A Holistic Formulation-Process Perspective
- (2016) Meng Li et al. Pharmaceutics
- Applying Biopharmaceutical Classification System (BCS) Criteria to Predict Oral Absorption of Drugs in Dogs: Challenges and Pitfalls
- (2015) Mark G. Papich et al. AAPS Journal
- Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization
- (2015) Vicente Martí-Centelles et al. CHEMICAL REVIEWS
- How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets
- (2015) Bradley C. Doak et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Prodrug Approach: A Successful Tool for Improving Drug Solubility
- (2015) Daniela Jornada et al. MOLECULES
- Molecular Property Design: Does Everyone Get It?
- (2015) Paul D. Leeson et al. ACS Medicinal Chemistry Letters
- Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
- (2014) Bradley Croy Doak et al. CHEMISTRY & BIOLOGY
- Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors
- (2014) Makonen Belema et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis
- (2014) Yan Lou et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms
- (2014) Shmuel Tuvia et al. PHARMACEUTICAL RESEARCH
- Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
- (2014) F. A. Russell et al. PHYSIOLOGICAL REVIEWS
- Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
- (2014) David B. Ascher et al. Scientific Reports
- Understanding the Molecular Properties and Metabolism of Top Prescribed Drugs
- (2013) Haizhen Zhong et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Effect of lyophilized grapefruit juice on P-glycoprotein-mediated drug transportin-vitroandin-vivo
- (2013) Iman S. Ahmed et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Animal versus human oral drug bioavailability: Do they correlate?
- (2013) Helen Musther et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Ligand interaction, binding site and G protein activation of the mu opioid receptor
- (2013) Xu Cui et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice
- (2013) Ulrika Tehler et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel therapies for hepatitis C — one pill fits all?
- (2013) Michael P. Manns et al. NATURE REVIEWS DRUG DISCOVERY
- Drugs in middle space
- (2013) Nick Terrett MedChemComm
- Predicting Efflux Ratios and Blood-Brain Barrier Penetration from Chemical Structure: Combining Passive Permeability with Active Efflux by P-Glycoprotein
- (2012) Elena Dolghih et al. ACS Chemical Neuroscience
- Going further than Lipinski's rule in drug design
- (2012) W Patrick Walters Expert Opinion on Drug Discovery
- Strategies to minimize CNS toxicity:in vitrohigh-throughput assays and computational modeling
- (2012) Travis T Wager et al. Expert Opinion on Drug Metabolism & Toxicology
- Ethylene Glycol-Linked Amino Acid Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics
- (2012) Feng Cao et al. MOLECULAR PHARMACEUTICS
- Increasing Oral Absorption of Polar Neuraminidase Inhibitors: A Prodrug Transporter Approach Applied to Oseltamivir Analogue
- (2012) Deepak Gupta et al. MOLECULAR PHARMACEUTICS
- De Novo Prediction of P-Glycoprotein-Mediated Efflux Liability for Druglike Compounds
- (2012) Hakan Gunaydin et al. ACS Medicinal Chemistry Letters
- In vitro and in vivo evaluation of novel immediate release carbamazepine tablets: Complexation with hydroxypropyl-β-cyclodextrin in the presence of HPMC
- (2011) Wen Kou et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-Glycoprotein at the Blood–Brain Barrier with Prodrug Abacavir Dimers
- (2011) Hilda A. Namanja et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ADME Evaluation in Drug Discovery. 9. Prediction of Oral Bioavailability in Humans Based on Molecular Properties and Structural Fingerprints
- (2011) Sheng Tian et al. MOLECULAR PHARMACEUTICS
- Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel
- (2011) Laurent Chatel-Chaix et al. Viruses-Basel
- Zinc Is Not Required for Activity of TPO Agonists Acting at the c-Mpl Receptor Transmembrane Domain
- (2010) Jessica Andrade et al. ACS Chemical Biology
- Predicting Total Clearance in Humans from Chemical Structure
- (2010) Melvin J. Yu Journal of Chemical Information and Modeling
- Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination
- (2010) Manthena V. S. Varma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intramolecular Hydrogen Bonding in Medicinal Chemistry
- (2010) Bernd Kuhn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods
- (2010) Leena Peltonen et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Elevated Saliva Calcitonin Gene-Related Peptide Levels During Acute Migraine Predict Therapeutic Response to Rizatriptan
- (2009) Roger K. Cady et al. HEADACHE
- Physicochemical Determinants of Human Renal Clearance
- (2009) Manthena V. S. Varma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Influence of molecular properties on oral bioavailability of lipophilic drugs – Mapping of bulkiness and different measures of polarity
- (2009) Martin Thomas Kuentz et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
- Use of the Biopharmaceutical Classification System in Early Drug Development
- (2008) M. Sherry Ku AAPS Journal
- Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor
- (2008) Noriko Yamane et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Enhanced Cancer Cell Growth Inhibition by Dipeptide Prodrugs of Floxuridine: Increased Transporter Affinity and Metabolic Stability
- (2008) Yasuhiro Tsume et al. MOLECULAR PHARMACEUTICS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now