Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

Pharmacological disruption of hepatitis C NS5A protein intra- and intermolecular conformations

(2013) D. Bhattacharya et al.   JOURNAL OF GENERAL VIROLOGY

Understanding the Biological Context of NS5A–Host Interactions in HCV Infection: A Network-Based Approach

(2013) Lokesh P. Tripathi et al.   JOURNAL OF PROTEOME RESEARCH

Characterizations of HCV NS5A replication complex inhibitors

(2013) Donald R. O'Boyle II et al.   VIROLOGY

Direct Detection of Antibody Concentration and Affinity in Human Serum Using Microscale Thermophoresis

(2012) Svenja Lippok et al.   ANALYTICAL CHEMISTRY

In VitroActivity of Daclatasvir on Hepatitis C Virus Genotype 3 NS5A

(2012) Chunfu Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

(2012) Chi-Chuan Lin et al.   CELL

Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation

(2012) Emily E. Bosco et al.   CHEMISTRY & BIOLOGY

HCV NS5A Inhibitors in Development

(2012) Anna Suk-Fong Lok   Clinics in Liver Disease

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation between NS5A Dimerization and Hepatitis C Virus Replication

(2012) Precious J. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

(2012) Samarjit Patnaik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Discovery of Substituted 4,5′-Bithiazoles as Novel DNA Gyrase Inhibitors

(2012) Matjaž Brvar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein

(2012) Oscar Belda et al.   VIRUS RESEARCH

In VitroActivity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A

(2011) Chunfu Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in Humans: In Vitro and In Vivo Correlations

(2011) Robert A. Fridell et al.   HEPATOLOGY

An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases

(2011) Marc G. Ghany et al.   HEPATOLOGY

Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

(2011) Dries Verdegem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization

(2011) D. Qiu et al.   JOURNAL OF GENERAL VIROLOGY

Distinct Functions of NS5A in Hepatitis C Virus RNA Replication Uncovered by Studies with the NS5A Inhibitor BMS-790052

(2011) R. A. Fridell et al.   JOURNAL OF VIROLOGY

Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

(2011) P. Targett-Adams et al.   JOURNAL OF VIROLOGY

The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein

(2011) Choongho Lee et al.   VIROLOGY

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diphenylcarboxamides as Inhibitors of HCV Non-Structural Protein NS5a

(2010) Malcolm Carter et al.   ANTIVIRAL RESEARCH

Recombinant HCV Variants With NS5A From Genotypes 1–7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

(2010) Troels K.H. Scheel et al.   GASTROENTEROLOGY

2003 ANTIVIRAL ACTIVITY, PHARMACOKINETICS, AND TOLERABILITY OF AZD7295, A NOVEL NS5A INHIBITOR, IN A PLACEBO-CONTROLLED MULTIPLE ASCENDING DOSE STUDY IN HCV GENOTYPE 1 AND 3 PATIENTS

(2010) E. Gane et al.   JOURNAL OF HEPATOLOGY

All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding

(2010) T. L. Foster et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins

(2010) J. Hwang et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

The Domain 2 of the HCV NS5A Protein Is Intrinsically Unstructured

(2010) Xavier Hanoulle et al.   PROTEIN AND PEPTIDE LETTERS

Identification of Hepatitis C Virus NS5A Inhibitors

(2009) J. A. Lemm et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY