The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury

(2015) Mijoon Lee et al.   ACS Chemical Neuroscience

Water-soluble prodrugs of paclitaxel containing self-immolative disulfide linkers

(2015) Machhindra Gund et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drug Carrier for Photodynamic Cancer Therapy

(2015) Tilahun Debele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NSAIDs do not require the presence of a carboxylic acid to exert their anti-inflammatory effect – why do we keep using it?

(2015) Nasir Ullah et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Gambogic acid induces apoptosis and inhibits colorectal tumor growthviamitochondrial pathways

(2015) Guang-Ming Huang   WORLD JOURNAL OF GASTROENTEROLOGY

Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV

(2015) Hardwin O’Dowd et al.   ACS Medicinal Chemistry Letters

A review of the efficacy and safety of eslicarbazepine acetate in the management of partial-onset seizures

(2015) Rodrigo Rocamora   Therapeutic Advances in Neurological Disorders

Potential of Piperazinylalkylester Prodrugs of 6-Methoxy-2-Naphthylacetic Acid (6-MNA) for Percutaneous Drug Delivery

(2014) Vijay Pawar et al.   AAPS PHARMSCITECH

Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation

(2014) Hong-Fei Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A highly water soluble benzimidazole derivative useful for the treatment of fasciolosis

(2014) Miguel Flores-Ramos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Investigation of amino acid conjugates of (S)-1-[1-(4-aminobenzoyl)-2,3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one (DW2282) as water soluble anticancer prodrugs

(2014) Ki-Cheul Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carboxymethylcellulose–tetrahydrocurcumin conjugates for colon-specific delivery of a novel anti-cancer agent, 4-amino tetrahydrocurcumin

(2014) Thipapun Plyduang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Synthesis and Characterization of Novel Sulphoxide prodrug of Famotidine

(2014) Surendran Vijayaraj et al.   Indian Journal of Pharmaceutical Education and Research

An FtsZ-Targeting Prodrug with Oral Antistaphylococcal EfficacyIn Vivo

(2013) Malvika Kaul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro,In Vivo, and Clinical Studies of Tedizolid To Assess the Potential for Peripheral or Central Monoamine Oxidase Interactions

(2013) S. Flanagan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723

(2013) Malvika Kaul et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of a new HIV-1 inhibitor scaffold and synthesis of potential prodrugs of indazoles

(2013) Se-Ho Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of diclofenac prodrugs for enhancing transdermal delivery

(2013) Shabbir Lobo et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

(2013) Alberto Diez-Torrubia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates

(2013) Jingyi Shen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of rat intestinal alkaline phosphatase – Role of crown domain in mammalian alkaline phosphatases

(2013) Kaushik Ghosh et al.   JOURNAL OF STRUCTURAL BIOLOGY

Synthesis and Evaluation of Water-Soluble Etoposide Esters of Malic Acid as Prodrugs

(2013) Jing Chen et al.   Medicinal Chemistry

Propylene Glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability, and Pharmacokinetics

(2013) Feng Cao et al.   MOLECULAR PHARMACEUTICS

Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors

(2013) Giulia Vignaroli et al.   ACS Medicinal Chemistry Letters

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

(2012) Samuel Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix

(2012) Katrin Hochdörffer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ethylene Glycol-Linked Amino Acid Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics

(2012) Feng Cao et al.   MOLECULAR PHARMACEUTICS

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dipeptidyl Peptidase IV Dependent Water-Soluble Prodrugs of Highly Lipophilic Bicyclic Nucleoside Analogues

(2011) Alberto Diez-Torrubia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Water-Soluble Gelatinase Inhibitor Prodrugs

(2011) Major Gooyit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemo-Enzymatic Synthesis of Ester-Linked Docetaxel-Monosaccharide Conjugates as Water-Soluble Prodrugs

(2011) Kei Shimoda et al.   MOLECULES

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

(2011) Vincent Gasparik et al.   ACS Medicinal Chemistry Letters

A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis

(2010) Shama Moktan et al.   INVESTIGATIONAL NEW DRUGS

QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue

(2010) Jia Zhou et al.   Journal of Chemical Theory and Computation

Imbuing Aqueous Solubility to Amphotericin B and Nystatin with a Vitamin

(2010) Timothy P. Day et al.   MOLECULAR PHARMACEUTICS

Eslicarbazepine Acetate: A Well-Kept Secret?

(2010)   Epilepsy Currents

Enhanced cytotoxicity of a polymer–drug conjugate with triple payload of paclitaxel

(2009) Rotem Erez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog

(2009) Jun Ohwada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Water-soluble prodrugs of an Aurora kinase inhibitor

(2009) Johan D. Oslob et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prodrug Approaches for Enhancing the Bioavailability of Drugs with Low Solubility

(2009) Christa E. Müller   CHEMISTRY & BIODIVERSITY

Prodrugs: bridging pharmacodynamic/pharmacokinetic gaps

(2009) Bernard Testa   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis and preliminary evaluation in vitro of novel naproxen-dendritic peptide conjugates

(2009) Liang Ouyang et al.   DRUG DELIVERY

Water-Soluble Prodrugs of the Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir

(2009) David A. DeGoey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrug Designing of NSAIDs

(2009) Parmeshwari Halen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Preparation and Evaluation of Taste Masked Famotidine Formulation Using Drug/β-cyclodextrin/Polymer Ternary Complexation Approach

(2008) Ashok R. Patel et al.   AAPS PHARMSCITECH

Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy

(2008) Mickaël Thomas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs

(2008) Mayo Noguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

(2008) Hanna Kumpulainen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12

(2008) Muriel Hachet-Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective drug delivery to bone using acidic oligopeptides

(2008) Junko Ishizaki et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Benzyl Ether-Linked Glucuronide Derivative of 10-Hydroxycamptothecin Designed for Selective Camptothecin-Based Anticancer Therapy

(2008) Yu-Ling Leu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrugs of Phosphates and Phosphonates

(2008) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

(2008) Paul S. Charifson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2

(2008) Karl Vollmann et al.   MOLECULES

Prodrugs for the Treatment of Neglected Diseases

(2008) Man Chung et al.   MOLECULES

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY