Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation

Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier

(2021) Yu-Ting Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A microneedle platform for buccal macromolecule delivery

(2021) Ester Caffarel-Salvador et al.   Science Advances

Advances in Oral Drug Delivery

(2021) Mohammed S. Alqahtani et al.   Frontiers in Pharmacology

Sodium glycodeoxycholate and sodium deoxycholate as epithelial permeation enhancers: in vitro and ex vivo intestinal and buccal bioassays

(2021) David J. Brayden et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

(2020) D.J. Brayden et al.   ADVANCED DRUG DELIVERY REVIEWS

Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions

(2020) Xiangfei Han et al.   Nature Nanotechnology

Intestinal permeation enhancers to improve oral bioavailability of macromolecules: reasons for low efficacy in humans

(2020) Sam Maher et al.   Expert Opinion on Drug Delivery

Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide

(2020) Susan L Samson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

(2020) Shakhawath Hossain et al.   MOLECULAR PHARMACEUTICS

A Pituitary Society update to acromegaly management guidelines

(2020) Maria Fleseriu et al.   Pituitary

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

(2020) Staffan Berg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro and Ex Vivo Evaluation of Penetratin as a Non-invasive Permeation Enhancer in the Penetration of Salmon Calcitonin through TR146 Buccal Cells and Porcine Buccal Tissues

(2020) Taekwang Keum et al.   Pharmaceuticals

Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial

(2019) Inge B Halberg et al.   Lancet Diabetes & Endocrinology

Acromegaly

(2019) Annamaria Colao et al.   Nature Reviews Disease Primers

Unmet therapeutic, educational and scientific needs in parathyroid disorders: Consensus Statement from the first European Society of Endocrinology Workshop (PARAT)

(2019) Jens Bollerslev et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

(2019) D. Dahlgren et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Preparation of an oil suspension containing ondansetron hydrochloride as a sustained release parenteral formulation

(2019) Thi-Thao-Linh Nguyen et al.   Drug Delivery and Translational Research

Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

(2019) Nicholas G. Lamson et al.   Nature Biomedical Engineering

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs

(2018) Sonja Bonengel et al.   JOURNAL OF CONTROLLED RELEASE

The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review

(2018) Laura J. Henze et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties

(2018) Jaclyn Y. Lock et al.   Scientific Reports

A Consensus Statement on acromegaly therapeutic outcomes

(2018) Shlomo Melmed et al.   Nature Reviews Endocrinology

Non-invasive delivery strategies for biologics

(2018) Aaron C. Anselmo et al.   NATURE REVIEWS DRUG DISCOVERY

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

(2018) Stephen T. Buckley et al.   Science Translational Medicine

Assessment of cell viability and permeation enhancement in presence of lipid-based self-emulsifying drug delivery systems using Caco-2 cell model: Polysorbate 80 as the surfactant

(2017) Pengli Bu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Intestinal permeation enhancers for oral peptide delivery

(2016) Sam Maher et al.   ADVANCED DRUG DELIVERY REVIEWS

INCIDENCE AND PREVALENCE OF ACROMEGALY IN THE UNITED STATES: A CLAIMS-BASED ANALYSIS

(2016) Michael S. Broder et al.   Endocrine Practice

Cabergoline in acromegaly

(2016) Emmanuelle Kuhn et al.   Pituitary

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

(2015) Aaron Lerner et al.   AUTOIMMUNITY REVIEWS

Patient-reported outcomes of parenteral somatostatin analogue injections in 195 patients with acromegaly

(2015) Christian J Strasburger et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Safety and Efficacy of Oral Octreotide in Acromegaly: Results of a Multicenter Phase III Trial

(2015) Shlomo Melmed et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Toward Oral Delivery of Biopharmaceuticals: An Assessment of the Gastrointestinal Stability of 17 Peptide Drugs

(2015) Jie Wang et al.   MOLECULAR PHARMACEUTICS

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Modification of gastric pH in the fasted dog

(2015) Britta Polentarutti et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells

(2014) David J. Brayden et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The role of citric acid in oral peptide and protein formulations: Relationship between calcium chelation and proteolysis inhibition

(2014) Søren H. Welling et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms

(2014) Shmuel Tuvia et al.   PHARMACEUTICAL RESEARCH

Pharmacokinetics of Oral Recombinant Human Parathyroid Hormone [rhPTH(1–31)NH2] in Postmenopausal Women with Osteoporosis

(2013) Amy Sturmer et al.   CLINICAL PHARMACOKINETICS

Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study

(2013) Roy Eldor et al.   PLoS One

Oral Octreotide Absorption in Human Subjects: Comparable Pharmacokinetics to Parenteral Octreotide and Effective Growth Hormone Suppression

(2012) S. Tuvia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oral peptide delivery by tetraether lipid liposomes

(2011) Johannes Parmentier et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice

(2011) Edward T. Maggio et al.   REGULATORY PEPTIDES

Pharmacological management of acromegaly: a current perspective

(2010) Sunil Manjila et al.   Neurosurgical Focus

Acromegaly pathogenesis and treatment

(2009) Shlomo Melmed   JOURNAL OF CLINICAL INVESTIGATION

Permeation Studies and Histological Examination of Sheep Nasal Mucosa Following Administration of Different Nasal Formulations with or without Absorption Enhancers

(2008) Ercüment Karasulu et al.   DRUG DELIVERY