Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors

Targeting Labile Iron-Mediated Ferroptosis Provides a Potential Therapeutic Strategy for Rhabdomyolysis-Induced Acute Kidney Injury

(2023) Haiying Zhu et al.   ACS Chemical Biology

Zooming in and out of ferroptosis in human disease

(2023) Xue Wang et al.   Frontiers of Medicine

The multifaceted role of ferroptosis in liver disease

(2022) Junyi Chen et al.   CELL DEATH AND DIFFERENTIATION

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

(2022) Xuexian Fang et al.   Nature Reviews Cardiology

Visible-Light 2,4-Dinitrophenol-Mediated Photoannulation of α-Azidochalcones into 2,5-Diaryloxazoles

(2022) Uma Devi Newar et al.   ORGANIC LETTERS

Ferroptosis in heart failure

(2022) Xinquan Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting ferroptosis: Paving new roads for drug design and discovery

(2022) Yilin Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ferroptosis inhibition by deferiprone, attenuates myelin damage and promotes neuroprotection in demyelinated optic nerve

(2022) Atefeh Rayatpour et al.   Scientific Reports

Inhibiting ferroptosis: A novel approach for stroke therapeutics

(2021) Yizhen Jin et al.   DRUG DISCOVERY TODAY

A compendium of kinetic modulatory profiles identifies ferroptosis regulators

(2021) Megan Conlon et al.   Nature Chemical Biology

Small-Molecule Inhibitors of Reactive Oxygen Species Production

(2021) Elisa Sassetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators

(2021) Jinho Seo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Ferroptosis is involved in the anti‑tumor effect of lycorine in renal cell carcinoma cells

(2021) Yang Du et al.   Oncology Letters

Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death

(2021) Omkar Zilka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease

(2020) Jun Liu et al.   ACS Medicinal Chemistry Letters

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

(2020) Wei Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

The Catalytic Reaction of Nitroxides with Peroxyl Radicals and Its Relevance to Their Cytoprotective Properties

(2018) Markus Griesser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease

(2015) Rong Sheng et al.   ACS Chemical Neuroscience

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

(2015) Marie-Helene Larraufie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective

(2014) Keith U. Ingold et al.   CHEMICAL REVIEWS

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL