Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin

The catalytic domains of all human KDM5 JmjC demethylases catalyse N ‐methyl arginine demethylation

(2023) Joanna Bonnici et al.   FEBS LETTERS

Functions and Interactions of Mammalian KDM5 Demethylases

(2022) Egor Pavlenko et al.   Frontiers in Genetics

The Prognostic Value of AT-Rich Interaction Domain (ARID) Family Members in Patients with Hepatocellular Carcinoma

(2022) Siyi Li et al.   Evidence-based Complementary and Alternative Medicine

Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway

(2022) Chang Liu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations

(2022) Fatima S. Ugur et al.   JOURNAL OF MOLECULAR BIOLOGY

Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions

(2021) Ramhari Kumbhar et al.   JOURNAL OF CELL BIOLOGY

KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2

(2021) Siyuan Xu et al.   Blood Advances

Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A

(2020) Nektaria Petronikolou et al.   BIOCHEMISTRY

Increased HDAC Activity and c-MYC Expression Mediate Acquired Resistance to WEE1 Inhibition in Acute Leukemia

(2020) Tamara B. Garcia et al.   Frontiers in Oncology

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

(2020) Yi Zhang et al.   Nature Communications

Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling

(2019) James E. Longbotham et al.   Nature Communications

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines

(2019) Guan-Jun Yang et al.   Cancers

HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner

(2019) Kostiantyn Dreval et al.   NUCLEIC ACIDS RESEARCH

Histone demethylase KDM5A is transactivated by the transcription factor C/EBPβ and promotes preadipocyte differentiation by inhibiting Wnt/β-catenin signaling

(2019) Liang Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism

(2019) Jiujie Cui et al.   ONCOGENE

Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation

(2018) Xiaoli Yu et al.   FASEB JOURNAL

The histone demethylase KDM5A is required for the repression of astrocytogenesis and regulated by the translational machinery in neural progenitor cells

(2018) Sun-Young Kong et al.   FASEB JOURNAL

Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity

(2018) Nicolás Palopoli et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair

(2017) Fade Gong et al.   JOURNAL OF CELL BIOLOGY

Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer

(2017) Hee-Joo Choi et al.   JNCI-Journal of the National Cancer Institute

KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance

(2017) Tongfu Feng et al.   Molecular Medicine Reports

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters

(2017) Zaffer Ullah Zargar et al.   NUCLEIC ACIDS RESEARCH

Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer

(2017) Hee-Joo Choi et al.   JNCI-Journal of the National Cancer Institute

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131

(2016) Radhika A. Varier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

(2016) Ann-Sofie B. Brier et al.   NUCLEIC ACIDS RESEARCH

KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis

(2016) Chuandong Wang et al.   Cell Death & Disease

SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability

(2016) Chao Huang et al.   Cell Reports

H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1

(2016) Dezhi Zhao et al.   Cell Reports

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

(2016) Jennifer M. Spangle et al.   Cell Reports

Histone demethylases in chromatin biology and beyond

(2015) E. Dimitrova et al.   EMBO REPORTS

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

(2015) Renáta Váraljai et al.   GENES & DEVELOPMENT

Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease

(2015) Yunhui Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases

(2015) John R. Horton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

(2015) Idelisse Ortiz Torres et al.   Nature Communications

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif

(2015) Xingyin Liu et al.   Cell Reports

Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex

(2014) Gohei Nishibuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis

(2014) Lupeng Li et al.   Molecular Cancer

Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

(2013) Y.-C. Teng et al.   CANCER RESEARCH

NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern

(2013) J D E de Rooij et al.   LEUKEMIA

Histone Demethylase Retinoblastoma Binding Protein 2 is Overexpressed in Hepatocellular Carcinoma and Negatively Regulated by hsa-miR-212

(2013) Xiuming Liang et al.   PLoS One

Histone lysine demethylases in breast cancer

(2012) Elisa Paolicchi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Phosphorylation of ORC2 Protein Dissociates Origin Recognition Complex from Chromatin and Replication Origins

(2012) Kyung Yong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EP300, KDM5A, KDM6A and KDM6B Chromatin Regulators Cooperate with KLF4 in the Transcriptional Activation of POU5F1

(2012) Wan-Ping Wang et al.   PLoS One

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation

(2012) M. L. Beshiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

(2012) A. Chicas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

(2011) S. M. Gough et al.   BLOOD

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

Chromatin states in pluripotent, differentiated, and reprogrammed cells

(2011) Cynthia L Fisher et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Drug-Tolerant Cancer Cells Show Reduced Tumor-Initiating Capacity: Depletion of CD44+ Cells and Evidence for Epigenetic Mechanisms

(2011) Hong Yan et al.   PLoS One

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

(2011) L. DiTacchio et al.   SCIENCE

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

(2010) R. Liefke et al.   GENES & DEVELOPMENT

Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase

(2009) Zheng Ge et al.   FASEB JOURNAL

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Crosstalk among Histone Modifications

(2008) Tamaki Suganuma et al.   CELL

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

(2008) D. Pasini et al.   GENES & DEVELOPMENT

A Role for Mammalian Sin3 in Permanent Gene Silencing

(2008) Chris van Oevelen et al.   MOLECULAR CELL

Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation

(2008) Nuria Lopez-Bigas et al.   MOLECULAR CELL

The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif

(2008) Shengjiang Tu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA