Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations

JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications

(2021) Vignesh Kasinath et al.   SCIENCE

Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A

(2021) James E. Longbotham et al.   ACS Chemical Biology

HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

(2021) Madeline M Keenen et al.   eLife

IUPred3: prediction of protein disorder enhanced with unambiguous experimental annotation and visualization of evolutionary conservation

(2021) Gábor Erdős et al.   NUCLEIC ACIDS RESEARCH

Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails

(2021) Yunhui Peng et al.   Nature Communications

Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures

(2021) Loredana Poeta et al.   Genes

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

(2020) Evan J Worden et al.   eLife

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate

(2020) Sang-Ah Kim et al.   MOLECULAR CELL

A partially disordered region connects gene repression and activation functions of EZH2

(2020) Lianying Jiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

(2020) Silvija Bilokapic et al.   NATURE

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

(2020) Wanqiu Li et al.   NATURE

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

(2020) Ksenia Finogenova et al.   eLife

Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling

(2019) James E. Longbotham et al.   Nature Communications

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

(2019) Chiara Marabelli et al.   Cell Reports

Structural basis of nucleosome recognition and modification by MLL methyltransferases

(2019) Han Xue et al.   NATURE

Nucleosome and ubiquitin position Set2 to methylate H3K36

(2019) Silvija Bilokapic et al.   Nature Communications

Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS

(2019) Peter L. Hsu et al.   MOLECULAR CELL

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

(2019) Sang Ho Park et al.   Nature Communications

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5

(2018) Sumaira Zamurrad et al.   Cell Reports

The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

(2018) Emma A Morrison et al.   eLife

Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability

(2018) Christina N. Vallianatos et al.   Frontiers in Molecular Neuroscience

Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains

(2018) Tyler Weaver et al.   MOLECULES

Accessibility of the histone H3 tail in the nucleosome for binding of paired readers

(2017) Jovylyn Gatchalian et al.   Nature Communications

Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons

(2017) Marilyn Scandaglia et al.   Cell Reports

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP

(2017) Sara Contreras-Martos et al.   Scientific Reports

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

(2016) Hongjie Shen et al.   CELL

Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails

(2016) Alexandra Stützer et al.   MOLECULAR CELL

Structural analysis of human KDM5B guides histone demethylase inhibitor development

(2016) Catrine Johansson et al.   Nature Chemical Biology

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation

(2016) Brianna J. Klein et al.   Cell Reports

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

(2016) Shigeki Iwase et al.   Cell Reports

Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity

(2015) Emily Brookes et al.   HUMAN MOLECULAR GENETICS

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases

(2015) John R. Horton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex

(2015) Sang-Ah Kim et al.   NUCLEIC ACIDS RESEARCH

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

(2015) Simona Pilotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

(2015) Idelisse Ortiz Torres et al.   Nature Communications

KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature

(2014) Thainá Fernandez Gonçalves et al.   European Journal of Medical Genetics

The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

(2014) Brianna J. Klein et al.   Cell Reports

Histone modifications for human epigenome analysis

(2013) Hiroshi Kimura   JOURNAL OF HUMAN GENETICS

Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function

(2013) Nikolay S. Outchkourov et al.   Cell Reports

Recognition of CpG Island Chromatin by KDM2A Requires Direct and Specific Interaction with Linker DNA

(2011) J. C. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity

(2010) Wenming Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

(2010) Neil P. Blackledge et al.   MOLECULAR CELL

Essential Functions of the Histone Demethylase Lid

(2010) Ling Li et al.   PLoS Genetics

Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype–phenotype correlation

(2009) Sinitdhorn Rujirabanjerd et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif

(2008) Shengjiang Tu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY