Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway

The protective effect of rutin against the cisplatin-induced cochlear damage in vitro

(2022) Shimei Zheng et al.   NEUROTOXICOLOGY

The emerging role of KDM5A in human cancer

(2021) Guan-Jun Yang et al.   Journal of Hematology & Oncology

Metformin Alleviates Cisplatin-Induced Ototoxicity by Autophagy Induction Possibly via the AMPK/FOXO3a Pathway

(2021) Zhengrong Liang et al.   JOURNAL OF NEUROPHYSIOLOGY

Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis

(2021) Rósula García-Navas et al.   ONCOGENE

SOD2 Alleviates Hearing Loss Induced by Noise and Kanamycin in Mitochondrial DNA4834-deficient Rats by Regulating PI3K/MAPK Signaling

(2021) Yan Zhang et al.   Current Medical Science

Pharmacological inhibition of KDM5A for cancer treatment

(2021) Guan-Jun Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1–PI3K/AKT pathway

(2021) Yingzi He et al.   Acta Pharmaceutica Sinica B

Co-existence of hepatocellular carcinoma and cystic echinococcosis

(2020) Ran Bo et al.   Infectious Agents and Cancer

Peptide‐conjugated long‐lived theranostic imaging toolbox for targeting GRPr in cancer and immune cells

(2020) Wanhe Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

E6 hijacks KDM5C/lnc_000231/miR‐497‐5p/CCNE1 axis to promote cervical cancer progression

(2020) Yan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

(2020) Patricia L Theard et al.   eLife

MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

(2020) Jane E. Craig et al.   Cell Death Discovery

SOS GEFs in health and disease

(2020) Fernando C. Baltanás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Histone H3 lysine K4 methylation and its role in learning and memory

(2019) Bridget E. Collins et al.   Epigenetics & Chromatin

Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses

(2019) Sabine Suire et al.   JOURNAL OF LEUKOCYTE BIOLOGY

KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN

(2019) Zhe Hong et al.   BIOMEDICINE & PHARMACOTHERAPY

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice

(2019) Yan Liu et al.   LIFE SCIENCES

Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1

(2018) Bin Dai et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

(2018) Ao Li et al.   DRUG DELIVERY

The histone demethylase KDM5A is required for the repression of astrocytogenesis and regulated by the translational machinery in neural progenitor cells

(2018) Sun-Young Kong et al.   FASEB JOURNAL

KDM5 demethylases and their role in cancer cell chemoresistance

(2018) J. Plch et al.   INTERNATIONAL JOURNAL OF CANCER

STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells

(2018) Meijuan Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity

(2018) Kyung-Hee Kim et al.   Cell Death & Disease

PINK1 Protects Against Gentamicin-Induced Sensory Hair Cell Damage: Possible Relation to Induction of Autophagy and Inhibition of p53 Signal Pathway

(2018) Qianqian Yang et al.   Frontiers in Molecular Neuroscience

Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization

(2017) Ryan M. Kiefer et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance

(2017) Tongfu Feng et al.   Molecular Medicine Reports

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

(2017) Bifeng Pan et al.   NATURE BIOTECHNOLOGY

Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea

(2017) Celia Zhang et al.   NEUROSCIENCE

Cisplatin is retained in the cochlea indefinitely following chemotherapy

(2017) Andrew M. Breglio et al.   Nature Communications

Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction

(2017) Jun Suzuki et al.   Scientific Reports

Ototoxicity and cancer therapy

(2016) Wendy Landier   CANCER

HEI-OC1 cells as a model for investigating drug cytotoxicity

(2016) Gilda Kalinec et al.   HEARING RESEARCH

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

(2016) Maia Vinogradova et al.   Nature Chemical Biology

Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs

(2016) P Liceras-Boillos et al.   ONCOGENE

Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro

(2016) Zuhong He et al.   Scientific Reports

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

(2015) Renáta Váraljai et al.   GENES & DEVELOPMENT

Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness

(2015) T. Iizuka et al.   HUMAN MOLECULAR GENETICS

Lysine-specific demethylase 1 inhibitors protect cochlear spiral ganglion neurons against cisplatin-induced damage

(2015) Ao Li et al.   NEUROREPORT

The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways

(2015) Sofie Van Rossom et al.   Frontiers in Cellular Neuroscience

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

(2015) Oriana S. Fisher et al.   Nature Communications

Exploring the Preparation of Albendazole-Loaded Chitosan-Tripolyphosphate Nanoparticles

(2015) Bong-Seok Kang et al.   Materials

2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2

(2014) Li Ma et al.   CANCER LETTERS

Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced Apoptosis

(2014) Yingzi He et al.   MOLECULAR NEUROBIOLOGY

Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis

(2014) Jian Cao et al.   Cell Reports

Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

(2013) Y.-C. Teng et al.   CANCER RESEARCH

Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival

(2013) Fernando C. Baltanás et al.   MOLECULAR AND CELLULAR BIOLOGY

Cochlear Inner Hair Cell Ribbon Synapse is the Primary Target of Ototoxic Aminoglycoside Stimuli

(2013) Ke Liu et al.   MOLECULAR NEUROBIOLOGY

Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death

(2013) H Yu et al.   Cell Death & Disease

The cytoprotective effect of butin against oxidative stress is mediated by the up-regulation of manganese superoxide dismutase expression through a PI3K/Akt/Nrf2-dependent pathway

(2012) Rui Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

AKT Signaling Mediates IGF-I Survival Actions on Otic Neural Progenitors

(2012) Maria R. Aburto et al.   PLoS One

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation

(2012) M. L. Beshiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

(2012) A. Chicas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ototoxicity: Mechanisms of Cochlear Impairment and its Prevention

(2011) K. Tabuchi et al.   CURRENT MEDICINAL CHEMISTRY

Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice

(2011) Kelly L. Kane et al.   HEARING RESEARCH

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Cochlear Morphology and Apoptosis in Mouse Models of Presbycusis

(2010) Shi-Nae Park et al.   Clinical and Experimental Otorhinolaryngology

The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells

(2009) Jiping Zeng et al.   GASTROENTEROLOGY

Effects of sex, gonadal hormones, and augmented acoustic environments on sensorineural hearing loss and the central auditory system: Insights from research on C57BL/6J mice

(2008) James F. Willott   HEARING RESEARCH

Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation

(2008) Nuria Lopez-Bigas et al.   MOLECULAR CELL