TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins

CCPG1 recognizes ER luminal proteins for selective ER-phagy

(2023) Shunsuke Ishii et al.   MOLECULAR BIOLOGY OF THE CELL

Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis

(2022) John C Christianson et al.   EMBO JOURNAL

ER-phagy: mechanisms, regulation and diseases connected to the lysosomal clearance of the endoplasmic reticulum

(2022) Fulvio Reggiori et al.   PHYSIOLOGICAL REVIEWS

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

(2022) Xinyu Ma et al.   CELL

Mapping SP-C co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation

(2022) Kristine F. R. Pobre-Piza et al.   Nature Communications

TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression

(2022) Tai-Mei Zhang et al.   Autophagy

Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin

(2022) Andrew Kennedy et al.   MOLECULAR BIOLOGY OF THE CELL

RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy

(2022) Jing Zhang et al.   Nature Communications

DNAJB12 and Hsp70 Triage Arrested Intermediates of N1303K-CFTR for ER Associated-Autophagy

(2021) Lihua He et al.   MOLECULAR BIOLOGY OF THE CELL

Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation

(2021) Priyanka Tripathi et al.   Cell Death & Disease

Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control

(2021) Alessio Reggio et al.   EMBO REPORTS

Endocytosis in the context-dependent regulation of individual and collective cell properties

(2021) Sara Sigismund et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation

(2021) Zhihao Sun et al.   Cell Reports

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

(2021) Yu-Jie Chen et al.   Nature Communications

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

(2020) Vladislav Pokatayev et al.   NATURE IMMUNOLOGY

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy

(2020) Thaddaeus Mutugi Nthiga et al.   EMBO JOURNAL

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

(2020) Madlen Stephani et al.   eLife

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

(2020) Shireen A. Sarraf et al.   MOLECULAR CELL

Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

(2019) Justin T. Marinko et al.   CHEMICAL REVIEWS

A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

(2019) João P. L. Coelho et al.   Nature Communications

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

How is alpha‐synuclein cleared from the cell?

(2019) Leonidas Stefanis et al.   JOURNAL OF NEUROCHEMISTRY

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

(2019) Haruka Chino et al.   MOLECULAR CELL

Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

(2019) Eszter Zavodszky et al.   eLife

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

The N-Degron Pathway Mediates ER-phagy

(2019) Chang Hoon Ji et al.   MOLECULAR CELL

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates

(2019) Corey N. Cunningham et al.   MOLECULAR CELL

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase

(2018) Tsukasa Okiyoneda et al.   DEVELOPMENTAL CELL

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

The degradation pathway of a model misfolded protein is determined by aggregation propensity

(2018) Zhihao Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Atlastins remodel the endoplasmic reticulum for selective autophagy

(2018) Jin Rui Liang et al.   JOURNAL OF CELL BIOLOGY

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

(2018) Mark L. Schultz et al.   Nature Communications

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

(2018) Alison Forrester et al.   EMBO JOURNAL

Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics

(2017) Anna Chiara Nascimbeni et al.   FEBS Journal

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism

(2015) Shuyan Xiao et al.   STRUCTURE

ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway

(2014) Prasanna Satpute-Krishnan et al.   CELL

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

(2014) E. L. Scotter et al.   JOURNAL OF CELL SCIENCE

Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR

(2014) Scott A. Houck et al.   MOLECULAR CELL

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

SOD1 as a Molecular Switch for Initiating the Homeostatic ER Stress Response under Zinc Deficiency

(2013) Kengo Homma et al.   MOLECULAR CELL

Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment

(2013) Marijn Kuijpers et al.   Acta Neuropathologica Communications

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

(2012) Takao Fujisawa et al.   ANNALS OF NEUROLOGY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate

(2012) Ryan E. Tyler et al.   MOLECULAR BIOLOGY OF THE CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides

(2011) Gayatri Ankem et al.   BIOCHEMICAL JOURNAL

N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stress

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Characterization of inclusion bodies with cytoprotective properties formed by seipinopathy-linked mutant seipin

(2011) Daisuke Ito et al.   HUMAN MOLECULAR GENETICS

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LSsubstrates

(2010) Riccardo Bernasconi et al.   JOURNAL OF CELL BIOLOGY

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Quality control of overexpressed membrane proteins

(2008) E. R. Geertsma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA