Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control

FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes

(2021) Marc Siggel et al.   Journal of Physical Chemistry Letters

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

(2020) Paula Lindner et al.   Cell Communication and Signaling

FAM 134B oligomerization drives endoplasmic reticulum membrane scission for ER ‐phagy

(2020) Xiao Jiang et al.   EMBO JOURNAL

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy

(2020) Thaddaeus Mutugi Nthiga et al.   EMBO JOURNAL

MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B

(2020) Laura Cinque et al.   EMBO JOURNAL

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

(2020) Keisuke Mochida et al.   Nature Communications

The critical role of PPARα in the binary switch between life and death induced by endoplasmic reticulum stress

(2020) Ling Xu et al.   Cell Death & Disease

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

Emerging Principles of Selective ER Autophagy

(2019) Simon Wilkinson   JOURNAL OF MOLECULAR BIOLOGY

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

(2019) Haruka Chino et al.   MOLECULAR CELL

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy

(2019) Ramachandra M. Bhaskara et al.   Nature Communications

The N-Degron Pathway Mediates ER-phagy

(2019) Chang Hoon Ji et al.   MOLECULAR CELL

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates

(2019) Corey N. Cunningham et al.   MOLECULAR CELL

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress

(2019) Marisa Loi et al.   Nature Communications

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

(2018) Kyoko Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

(2018) Mark L. Schultz et al.   Nature Communications

Open questions: why should we care about ER-phagy and ER remodelling?

(2018) Ivan Dikic   BMC BIOLOGY

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

(2018) Alison Forrester et al.   EMBO JOURNAL

Noncanonical autophagy at ER exit sites regulates procollagen turnover

(2018) Shakib Omari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

(2017) Pankaj Sehgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

(2017) Yusuke Toyoda et al.   Nature Communications

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER

(2016) J. Nixon-Abell et al.   SCIENCE

Form Follows Function: The Importance of Endoplasmic Reticulum Shape

(2015) L.M. Westrate et al.   Annual Review of Biochemistry

Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations

(2015) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides

(2015) Konstantinos D. Tsirigos et al.   NUCLEIC ACIDS RESEARCH

JK1 (FAM134B) represses cell migration in colon cancer: a functional study of a novel gene

(2014) Kais Kasem et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

AlignMe—a membrane protein sequence alignment web server

(2014) Marcus Stamm et al.   NUCLEIC ACIDS RESEARCH

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

ER structure and function

(2013) Shuliang Chen et al.   CURRENT OPINION IN CELL BIOLOGY

Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons

(2013) Jen-Ling Wang et al.   GENE

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

(2009) Ingo Kurth et al.   NATURE GENETICS

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

(2009) Wendy R. Gordon et al.   PLoS One

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH