Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation

Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation

(2020) Julia D. Knopf et al.   JOURNAL OF CELL SCIENCE

Protein quality control in the endoplasmic reticulum

(2020) Ben P. Phillips et al.   CURRENT OPINION IN CELL BIOLOGY

Protein transport by vesicles and tunnels

(2019) Ishier Raote et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Compartmentalization and Selective Tagging for Disposal of Misfolded Glycoproteins

(2019) Marina Shenkman et al.   TRENDS IN BIOCHEMICAL SCIENCES

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

(2019) Yixian Cui et al.   SCIENCE

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

Direct visualization of degradation microcompartments at the ER membrane

(2019) Sahradha Albert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The degradation pathway of a model misfolded protein is determined by aggregation propensity

(2018) Zhihao Sun et al.   MOLECULAR BIOLOGY OF THE CELL

ER-phagy at a glance

(2018) Paolo Grumati et al.   JOURNAL OF CELL SCIENCE

Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates

(2017) Christopher J. Guerriero et al.   MOLECULAR BIOLOGY OF THE CELL

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

(2017) Ling Qi et al.   TRENDS IN CELL BIOLOGY

Cargo Capture and Bulk Flow in the Early Secretory Pathway

(2016) Charles Barlowe et al.   Annual Review of Cell and Developmental Biology

Protein sorting at the ER–Golgi interface

(2016) Natalia Gomez-Navarro et al.   JOURNAL OF CELL BIOLOGY

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

(2016) W. Joon Chung et al.   PLoS One

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Transmembrane Domain Lengths Serve as Signatures of Organismal Complexity and Viral Transport Mechanisms

(2016) Snigdha Singh et al.   Scientific Reports

The Erv41–Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins

(2015) Aya Shibuya et al.   JOURNAL OF CELL BIOLOGY

Glycosylation-directed quality control of protein folding

(2015) Chengchao Xu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis

(2014) J. C. Genereux et al.   EMBO JOURNAL

Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding

(2013) Tal Keren-Kaplan et al.   EMBO JOURNAL

Secretory Protein Biogenesis and Traffic in the Early Secretory Pathway

(2013) C. K. Barlowe et al.   GENETICS

COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments

(2013) Shogo Kakoi et al.   MOLECULAR BIOLOGY OF THE CELL

A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress

(2013) Michal A. Surma et al.   MOLECULAR CELL

Improved Blue, Green, and Red Fluorescent Protein Tagging Vectors for S. cerevisiae

(2013) Sidae Lee et al.   PLoS One

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

(2012) Jason A. MacGurn et al.   Annual Review of Biochemistry

A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting

(2012) Zoi Erpapazoglou et al.   MOLECULAR BIOLOGY OF THE CELL

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

(2012) Michitaka Suzuki et al.   MOLECULAR BIOLOGY OF THE CELL

The Delicate Balance Between Secreted Protein Folding and Endoplasmic Reticulum-Associated Degradation in Human Physiology

(2012) Christopher J. Guerriero et al.   PHYSIOLOGICAL REVIEWS

Inhibition of Endoplasmic Reticulum-associated Degradation Rescues Native Folding in Loss of Function Protein Misfolding Diseases

(2011) Fan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination

(2011) Daniel K. Stringer et al.   JOURNAL OF CELL BIOLOGY

Sed4p Stimulates Sar1p GTP Hydrolysis and Promotes Limited Coat Disassembly

(2011) Chie Kodera et al.   TRAFFIC

Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases

(2010) Derrick Sek Tong Ong et al.   CURRENT OPINION IN CELL BIOLOGY

Evasion of Endoplasmic Reticulum Surveillance Makes Wsc1p an Obligate Substrate of Golgi Quality Control

(2010) Songyu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

(2010) Diane E. Grove et al.   MOLECULAR BIOLOGY OF THE CELL

Interplay of Substrate Retention and Export Signals in Endoplasmic Reticulum Quality Control

(2010) Shinichi Kawaguchi et al.   PLoS One

Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains

(2010) Shengkai Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins

(2009) Heike Kroeger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

(2009) Elsa Lauwers et al.   JOURNAL OF CELL BIOLOGY

Mechanisms for Rescue of Correctable Folding Defects in CFTRΔF508

(2009) Diane E. Grove et al.   MOLECULAR BIOLOGY OF THE CELL

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadmium-mediated rescue from ER-associated degradation induces expression of its exporter

(2009) D. J. Adle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases

(2008) Ting-Wei Mu et al.   CELL

Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

(2008) Kunio Nakatsukasa et al.   CELL

Protein quality control in the early secretory pathway

(2008) Tiziana Anelli et al.   EMBO JOURNAL

Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step

(2008) Joon No Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

(2008) B. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA