Amending the injured heart by in vivo reprogramming

Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct

(2023) Zhe Yu et al.   CIRCULATION

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure

(2022) Riham R.E. Abouleisa et al.   CIRCULATION

Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions

(2022) Jia Wang et al.   Nature Biomedical Engineering

Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes

(2022) Haofei Wang et al.   Cell Stem Cell

A coalition to heal—the impact of the cardiac microenvironment

(2022) Eldad Tzahor et al.   SCIENCE

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair

(2022) Ruorong Yan et al.   Cell Stem Cell

Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration

(2022) Yuan-Yuan Cheng et al.   CIRCULATION

Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction

(2022) Hidenori Tani et al.   CIRCULATION

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting

(2021) Ximeng Han et al.   Cell Stem Cell

Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration

(2021) Jiyoung Bae et al.   CIRCULATION

The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming

(2021) Glynnis A. Garry et al.   NATURE CELL BIOLOGY

Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state

(2021) Thomas Kisby et al.   PLoS One

Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming

(2021) Yawen Tang et al.   Stem Cell Research

Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity

(2021) Alexander Y. Payumo et al.   CIRCULATION

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

(2021) Yanpu Chen et al.   SCIENCE

Environmental factors influence somatic cell reprogramming to cardiomyocyte-like cells

(2021) Ben Van Handel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Direct cardiac reprogramming comes of age: Recent advance and remaining challenges

(2021) Yifang Xie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

(2021) Miao Cui et al.   Nature Communications

Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

(2021) Vivek P. Singh et al.   Journal of the American Heart Association

Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart

(2021) Melissa Valussi et al.   Science Advances

Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery

(2021) Magdalena M. Żak et al.   Pharmaceutics

Thyroid hormone-dependent regulation of metabolism and heart regeneration

(2021) Ines Ross et al.   JOURNAL OF ENDOCRINOLOGY

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

(2020) Ajit Magadum et al.   CIRCULATION

Non-coding RNA therapeutics for cardiac regeneration

(2020) Luca Braga et al.   CARDIOVASCULAR RESEARCH

A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes

(2020) Ngoc Uyen Nhi Nguyen et al.   NATURE

Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

(2020) Megan J. Bywater et al.   Nature Communications

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

(2020) Tapash Jay Sarkar et al.   Nature Communications

Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs

(2020) Andrea Baehr et al.   CIRCULATION

ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

(2020) Alla Aharonov et al.   NATURE CELL BIOLOGY

Down-regulation of Beclin1 promotes direct cardiac reprogramming

(2020) Li Wang et al.   Science Translational Medicine

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

(2020) Shota Kurotsu et al.   Stem Cell Reports

Specific Modified mRNA Translation System

(2020) Ajit Magadum et al.   CIRCULATION

Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

(2020) Miao Cui et al.   DEVELOPMENTAL CELL

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

(2019) Kentaro Hirose et al.   SCIENCE

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

(2019) Tanner O. Monroe et al.   DEVELOPMENTAL CELL

Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population

(2019) Michail Yekelchyk et al.   BASIC RESEARCH IN CARDIOLOGY

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

(2018) Tamer M.A. Mohamed et al.   CELL

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition

(2018) Tim A. Rand et al.   Cell Reports

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

(2016) Yang Zhou et al.   Cell Stem Cell

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac ReprogrammingClinical Perspective

(2016) Tamer M. A. Mohamed et al.   CIRCULATION

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

(2015) Abdenour Soufi et al.   CELL

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

(2015) Wataru Kimura et al.   NATURE

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

In Vivo Cardiac Cellular Reprogramming Efficacy Is Enhanced by Angiogenic Preconditioning of the Infarcted Myocardium With Vascular Endothelial Growth Factor

(2013) Megumi Mathison et al.   Journal of the American Heart Association

Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5

(2012) Kohei Inagawa et al.   CIRCULATION RESEARCH

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

(2012) Tilanthi M. Jayawardena et al.   CIRCULATION RESEARCH

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling

(2011) Thomas Kubin et al.   Cell Stem Cell

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

(2010) Preeti Ahuja et al.   JOURNAL OF CLINICAL INVESTIGATION