Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

(2020) Elaheh Karbassi et al.   Nature Reviews Cardiology

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

(2020) Hao Zhang et al.   eLife

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

(2019) Naoto Muraoka et al.   Nature Communications

EZH2 cooperates with gain‐of‐function p53 mutants to promote cancer growth and metastasis

(2019) Yu Zhao et al.   EMBO JOURNAL

Discovery of a first-in-class EZH2 selective degrader

(2019) Anqi Ma et al.   Nature Chemical Biology

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

(2018) Ralf Gilsbach et al.   Nature Communications

A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming

(2018) Yang Zhou et al.   Stem Cells International

iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data

(2018) Steven Xijin Ge et al.   BMC BIOINFORMATICS

Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

(2017) Ziqing Liu et al.   NATURE

Comparative Gene Expression Analyses Reveal Distinct Molecular Signatures between Differentially Reprogrammed Cardiomyocytes

(2017) Yang Zhou et al.   Cell Reports

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development

(2016) Rui Lu et al.   CANCER CELL

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

(2016) Yang Zhou et al.   Cell Stem Cell

Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes

(2016) Ziqing Liu et al.   Stem Cell Research

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts

(2016) Liu Liu et al.   Cell Discovery

In vivocardiac reprogramming using an optimal single polycistronic construct: Figure 1

(2015) Hong Ma et al.   CARDIOVASCULAR RESEARCH

Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes

(2015) Kavitha T. Kuppusamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of suppressive histone modification promote direct reprogramming of fibroblasts to cardiomyocyte-like cells

(2014) Hiroyuki Hirai et al.   CARDIOVASCULAR RESEARCH

Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

(2014) Y.-J. Nam et al.   DEVELOPMENT

MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

(2014) N. Muraoka et al.   EMBO JOURNAL

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

Regeneration potential of adult cardiac myocytes

(2013) Kyohei Oyama et al.   CELL RESEARCH

Direct Cardiac Reprogramming

(2013) Li Qian et al.   CIRCULATION RESEARCH

Chromatin dynamics during cellular reprogramming

(2013) Effie Apostolou et al.   NATURE

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Induced regeneration—the progress and promise of direct reprogramming for heart repair

(2013) Russell C Addis et al.   NATURE MEDICINE

Epigenetic programming and reprogramming during development

(2013) Irene Cantone et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reprogramming of human fibroblasts toward a cardiac fate

(2013) Y.-J. Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of human cardiomyocyte-like cells from fibroblasts by defined factors

(2013) R. Wada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

(2013) Ji-Dong Fu et al.   Stem Cell Reports

A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development

(2012) Sharon L. Paige et al.   CELL

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

(2012) Tilanthi M. Jayawardena et al.   CIRCULATION RESEARCH

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

CEAS: cis-regulatory element annotation system

(2009) Hyunjin Shin et al.   BIOINFORMATICS

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

(2008) M E Gonzalez et al.   ONCOGENE