Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions

Regenerating the field of cardiovascular cell therapy

(2019) Kenneth R. Chien et al.   NATURE BIOTECHNOLOGY

Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell–Derived Cardiomyocytes for Myocardial Repair

(2019) Ramaswamy Kannappan et al.   CIRCULATION

An acute immune response underlies the benefit of cardiac stem-cell therapy

(2019) Ronald J. Vagnozzi et al.   NATURE

Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases

(2018) Yan Li et al.   CIRCULATION

Genetic Lineage Tracing of Sca-1+Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart

(2018) Ronald J. Vagnozzi et al.   CIRCULATION

Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman PrimatesNovelty and Significance

(2018) Keyang Zhu et al.   CIRCULATION RESEARCH

Small molecule-induced cellular fate reprogramming: promising road leading to Rome

(2018) Xiang Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells

(2018) Shin-ya Yasuda et al.   Nature Biomedical Engineering

Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1–Positive Cells in the Adult Mouse Heart

(2018) Lauren E. Neidig et al.   CIRCULATION

Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage

(2017) Shangtao Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine

(2017) Ling Gao et al.   CIRCULATION

CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2017) Wuqiang Zhu et al.   CIRCULATION RESEARCH

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

(2016) Yang Zhou et al.   Cell Stem Cell

Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules

(2016) Yunfang Wang et al.   Cell Stem Cell

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts

(2016) Yu Zhang et al.   Cell Stem Cell

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors

(2016) Pratik A. Lalit et al.   Cell Stem Cell

Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation

(2016) Mingliang Zhang et al.   Cell Stem Cell

Finding Expandable Induced Cardiovascular Progenitor Cells

(2016) Ian Y. Chen et al.   CIRCULATION RESEARCH

Expandable progenitors from induced pluripotent stem cells

(2016) Shigeo Masuda et al.   Nature Reviews Cardiology

Conversion of human fibroblasts into functional cardiomyocytes by small molecules

(2016) Nan Cao et al.   SCIENCE

Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes

(2016) Yongshun Lin et al.   Stem Cells Translational Medicine

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

(2016) Xiaoping Bao et al.   Nature Biomedical Engineering

A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming

(2015) Yang Zhao et al.   CELL

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

(2015) Matthew J Birket et al.   NATURE BIOTECHNOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Nonstochastic Reprogramming from a Privileged Somatic Cell State

(2014) Shangqin Guo et al.   CELL

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

Small Molecules Enable Cardiac Reprogramming of Mouse Fibroblasts with a Single Factor, Oct4

(2014) Haixia Wang et al.   Cell Reports

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

(2014) W Patrick Devine et al.   eLife

Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions

(2013) Nan Cao et al.   CELL RESEARCH

Extraembryonic Endoderm cells as a model of endoderm development

(2013) Asja T. Moerkamp et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

(2012) Joseph A. Wamstad et al.   CELL

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Chromatin-modifying enzymes as modulators of reprogramming

(2012) Tamer T. Onder et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

(2011) Steven J. Kattman et al.   Cell Stem Cell

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Assessment and Optimization of Cell Engraftment After Transplantation Into the Heart

(2010) John V. Terrovitis et al.   CIRCULATION RESEARCH

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates

(2010) Guillaume Blin et al.   JOURNAL OF CLINICAL INVESTIGATION

Open chromatin in pluripotency and reprogramming

(2010) Alexandre Gaspar-Maia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Engraftment, Differentiation, and Functional Benefits of Autologous Cardiosphere-Derived Cells in Porcine Ischemic Cardiomyopathy

(2009) Peter V. Johnston et al.   CIRCULATION