Direct cardiac reprogramming comes of age: Recent advance and remaining challenges

Direct cell reprogramming: approaches, mechanisms and progress

(2021) Haofei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes

(2021) Li Wang et al.   CARDIOVASCULAR RESEARCH

Toward the Goal of Human Heart Regeneration

(2020) Hesham Sadek et al.   Cell Stem Cell

Down-regulation of Beclin1 promotes direct cardiac reprogramming

(2020) Li Wang et al.   Science Translational Medicine

Challenges in unsupervised clustering of single-cell RNA-seq data

(2019) Vladimir Yu Kiselev et al.   NATURE REVIEWS GENETICS

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

(2019) Hisayuki Hashimoto et al.   Cell Stem Cell

A comparison of single-cell trajectory inference methods

(2019) Wouter Saelens et al.   NATURE BIOTECHNOLOGY

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming

(2019) Nicole R. Stone et al.   Cell Stem Cell

Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming

(2019) Yang Zhou et al.   Cell Stem Cell

Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

(2018) Kazutaka Miyamoto et al.   Cell Stem Cell

Single-Cell Transcriptomics Meets Lineage Tracing

(2018) Lennart Kester et al.   Cell Stem Cell

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Single-Cell DNA Methylation Profiling: Technologies and Biological Applications

(2018) Ino D. Karemaker et al.   TRENDS IN BIOTECHNOLOGY

Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor

(2018) Megan Crow et al.   Nature Communications

Human pluripotent reprogramming with CRISPR activators

(2018) Jere Weltner et al.   Nature Communications

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

Initiating Events in Direct Cardiomyocyte Reprogramming

(2018) Kimberly Sauls et al.   Cell Reports

CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming

(2018) Yanxia Liu et al.   Cell Stem Cell

ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression

(2017) Huanyu Zhou et al.   GENES & DEVELOPMENT

In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration

(2017) Megumi Mathison et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

(2017) Ziqing Liu et al.   NATURE

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

SC3: consensus clustering of single-cell RNA-seq data

(2017) Vladimir Yu Kiselev et al.   NATURE METHODS

Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming

(2017) Nazish Sayed et al.   STEM CELLS

Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

(2017) Maria Abad et al.   Stem Cell Reports

Effect of biophysical cues on reprogramming to cardiomyocytes

(2016) Junren Sia et al.   BIOMATERIALS

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

(2016) Yang Zhou et al.   Cell Stem Cell

Hypoxia Enhances Direct Reprogramming of Mouse Fibroblasts to Cardiomyocyte-Like Cells

(2016) Yanyan Wang et al.   Cellular Reprogramming

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac ReprogrammingClinical Perspective

(2016) Tamer M. A. Mohamed et al.   CIRCULATION

Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes

(2016) Ziqing Liu et al.   Stem Cell Research

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts

(2016) Liu Liu et al.   Cell Discovery

Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues

(2015) Constant Morez et al.   BIOMATERIALS

In vivocardiac reprogramming using an optimal single polycistronic construct: Figure 1

(2015) Hong Ma et al.   CARDIOVASCULAR RESEARCH

Defining cell types and states with single-cell genomics

(2015) Cole Trapnell   GENOME RESEARCH

Advances and Applications of Single-Cell Sequencing Technologies

(2015) Yong Wang et al.   MOLECULAR CELL

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state

(2015) Assaf Rotem et al.   NATURE BIOTECHNOLOGY

Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

(2015) Tianhua Ma et al.   NATURE CELL BIOLOGY

Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes

(2015) Huanyu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling

(2015) Yuanbiao Zhao et al.   Nature Communications

Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions

(2015) Hiroyuki Yamakawa et al.   Stem Cell Reports

MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

(2014) N. Muraoka et al.   EMBO JOURNAL

Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes

(2014) Jamie L. Ifkovits et al.   PLoS One

Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain

(2013) Hiroyuki Hirai et al.   CARDIOVASCULAR RESEARCH

Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency

(2013) Shuo Wang et al.   Cell Stem Cell

Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success

(2013) Russell C. Addis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transcription Factors MYOCD, SRF, Mesp1 and SMARCD3 Enhance the Cardio-Inducing Effect of GATA4, TBX5, and MEF2C during Direct Cellular Reprogramming

(2013) Nicolas Christoforou et al.   PLoS One

Induction of human cardiomyocyte-like cells from fibroblasts by defined factors

(2013) R. Wada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

(2013) Ji-Dong Fu et al.   Stem Cell Reports

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

(2012) Jenny X. Chen et al.   CIRCULATION RESEARCH

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

(2012) Tilanthi M. Jayawardena et al.   CIRCULATION RESEARCH

A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells

(2012) Stephanie Protze et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Transcriptional regulation is only half the story

(2010) Joshua B Plotkin   Molecular Systems Biology

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Forcing cells to change lineages

(2009) Thomas Graf et al.   NATURE