Peptide-based molecules for the disruption of bacterial Hsp70 chaperones

Functional Effects of ARV-1502 Analogs Against Bacterial Hsp70 and Implications for Antimicrobial Activity

(2022) Alexandra Brakel et al.   Frontiers in Chemistry

Delivering hydrophilic peptide inhibitors of heat shock protein 70 into cancer cells

(2022) Zifei Han et al.   BIOORGANIC CHEMISTRY

Influence of Substitutions in the Binding Motif of Proline-Rich Antimicrobial Peptide ARV-1502 on 70S Ribosome Binding and Antimicrobial Activity

(2022) Alexandra Brakel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Cofactor Mimics Disrupt Essential Chaperone Function in Stressed Mycobacteria

(2022) Brock Nelson et al.   ACS Infectious Diseases

Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78

(2022) Andrew J. Ambrose et al.   Journal of Medicinal Chemistry

Function, Therapeutic Potential, and Inhibition of Hsp70 Chaperones

(2021) Andrew J. Ambrose et al.   JOURNAL OF MEDICINAL CHEMISTRY

The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria

(2021) Allison Fay et al.   mBio

Bacterial Hsp90 Facilitates the Degradation of Aggregation-Prone Hsp70–Hsp40 Substrates

(2021) Bruno Fauvet et al.   Frontiers in Molecular Biosciences

Novel Antibacterial Targets in Protein Biogenesis Pathways

(2021) Upasana S. Potteth et al.   CHEMBIOCHEM

The interactions of molecular chaperones with client proteins: why are they so weak?

(2021) Taylor Arhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones

(2021) Erik B. Nordquist et al.   PLoS Computational Biology

Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

(2020) Rahmi Imamoglu et al.   Nature Communications

KLR-70: A Novel Cationic Inhibitor of the Bacterial Hsp70 Chaperone

(2020) Matthew D. Dalphin et al.   BIOCHEMISTRY

Recent advances in understanding catalysis of protein folding by molecular chaperones

(2020) David Balchin et al.   FEBS LETTERS

Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function

(2020) Si Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

(2020) Marta Lukačišinová et al.   Nature Communications

Non‐redundant functions of Mycobacterium tuberculosis chaperones promote survival under stress

(2020) Alexa Harnagel et al.   MOLECULAR MICROBIOLOGY

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

(2020) Nicholas G. Welch et al.   Frontiers in Chemistry

A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78

(2019) Andrew J. Ambrose et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

Inhibitors and chemical probes for molecular chaperone networks

(2018) Jason E. Gestwicki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

(2018) Olivier Genest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Control of Tertiary Helical Structures in Short Peptides

(2018) Michael G. Wuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti-cancer drugs

(2017) Dmitry V. Sverchinsky et al.   FEBS LETTERS

Role and mechanism of the Hsp70 molecular chaperone machines in bacterial pathogens

(2017) Ciamak Ghazaei   JOURNAL OF MEDICAL MICROBIOLOGY

Proline-rich antimicrobial peptides targeting protein synthesis

(2017) Michael Graf et al.   NATURAL PRODUCT REPORTS

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

Reconstitution of aMycobacterium tuberculosisproteostasis network highlights essential cofactor interactions with chaperone DnaK

(2016) Tania J. Lupoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

(2016) Gerard D. Wright   TRENDS IN MICROBIOLOGY

Influence of theyjiL-mdtMGene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System

(2015) Andor Krizsan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone

(2015) Jung Ho Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the conformation of a client protein through the Hsp70 functional cycle

(2015) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DnaK as Antibiotic Target: Hot Spot Residues Analysis for Differential Inhibition of the Bacterial Protein in Comparison with the Human HSP70

(2015) Federica Chiappori et al.   PLoS One

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

(2014) Wenyi Li et al.   AMINO ACIDS

Insect-Derived Proline-Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome

(2014) Andor Krizsan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7

(2014) Michael Zahn et al.   PROTEIN AND PEPTIDE LETTERS

Cellular Uptake of Apidaecin 1b and Related Analogs in Gram-negative Bacteria Reveals Novel Antibacterial Mechanism for Proline-rich Antimicrobial Peptides

(2014) Nicole Berthold et al.   PROTEIN AND PEPTIDE LETTERS

An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding

(2014) Allison Fay et al.   PLoS Genetics

Inhibitors of Difficult Protein–Protein Interactions Identified by High-Throughput Screening of Multiprotein Complexes

(2013) Laura C. Cesa et al.   ACS Chemical Biology

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

(2013) Anna Rodina et al.   CHEMISTRY & BIOLOGY

Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK

(2013) Michael Zahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

(2013) Benjamin Matteson Vincent et al.   PLOS BIOLOGY

Api88 Is a Novel Antibacterial Designer Peptide To Treat Systemic Infections with Multidrug-Resistant Gram-Negative Pathogens

(2012) Patricia Czihal et al.   ACS Chemical Biology

Novel Apidaecin 1b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

(2012) Nicole Berthold et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

DnaK Functions as a Central Hub in the E. coli Chaperone Network

(2012) Giulia Calloni et al.   Cell Reports

Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy

(2011) Anne-Laure Rérole et al.   CANCER RESEARCH

Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action

(2011) Marco Scocchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex

(2011) Daniel Knappe et al.   CHEMBIOCHEM

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Heat shock protein 90 from Escherichia coli collaborates with the DnaK chaperone system in client protein remodeling

(2011) O. Genest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Novel Peptidic DnaK Ligands

(2010) Markus Liebscher et al.   CHEMBIOCHEM

Small Molecule DnaK Modulators Targeting the β-Domain

(2009) Jason Cellitti et al.   Chemical Biology & Drug Design

The Antibacterial Effect of a Proline-Rich Antibacterial Peptide A3-APO

(2009) F. Rozgonyi et al.   CURRENT MEDICINAL CHEMISTRY

The Proline-rich Antibacterial Peptide Bac7 Binds to and Inhibits in vitro the Molecular Chaperone DnaK

(2009) Marco Scocchi et al.   International Journal of Peptide Research and Therapeutics

Identification of small molecules that modify the protein folding activity of heat shock protein 70

(2008) Susanne Wisén et al.   ANALYTICAL BIOCHEMISTRY

Molecular Basis for Regulation of the Heat Shock Transcription Factor σ32 by the DnaK and DnaJ Chaperones

(2008) Fernanda Rodriguez et al.   MOLECULAR CELL

Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics

(2008) Marco Cassone et al.   PEPTIDES

Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo

(2008) Paul Bart Noto et al.   PROTEIN SCIENCE

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY