Novel Antibacterial Targets in Protein Biogenesis Pathways

Antibiotic resistance has emerged as a global threat due to the ability of bacteria to quickly evolve in response to the selection pressure induced by anti-infective drugs. Thus, there is an urgent need to develop new antibiotics against resistant bacteria. In this review, we discuss pathways involving bacterial protein biogenesis as attractive antibacterial targets since many of them are essential for bacterial survival and virulence. We discuss the structural understanding of various components associated with bacterial protein biogenesis, which in turn can be utilized for rational antibiotic design. We highlight efforts made towards developing inhibitors of these pathways with insights into future possibilities and challenges. We also briefly discuss other potential targets related to protein biogenesis.

Automated summary

Antibiotic resistance is a global threat due to bacterial evolution in response to anti-infective drugs. There is an urgent need for new antibiotics. Bacterial protein biogenesis pathways are discussed as attractive targets, with efforts towards developing inhibitors and exploring potential challenges and future possibilities. Other potential targets related to protein biogenesis are briefly mentioned.