Ro52/TRIM21 – From host defense to autoimmunity

Multiple Roles of TRIM21 in Virus Infection

(2023) Xue Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical and laboratory features of childhood-onset primary Sjögren's syndrome: A retrospective study from China

(2023) Chenxi Liu et al.   Frontiers in Pediatrics

Anti-Ro52 Autoantibody Is Common in Systemic Autoimmune Rheumatic Diseases and Correlating with Worse Outcome when Associated with interstitial lung disease in Systemic Sclerosis and Autoimmune Myositis

(2022) Edward K. L. Chan   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Anti-Ro52 antibodies are associated with the prognosis of adult idiopathic inflammatory myopathy-associated interstitial lung disease

(2022) Xianhua Gui et al.   RHEUMATOLOGY

TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer

(2022) Jieyun Sun et al.   Bioengineered

Anti-Ro52/TRIM21 serological subsets identify differential clinical and laboratory parameters

(2022) Adrian Y. S. Lee et al.   CLINICAL RHEUMATOLOGY

Humoral and cellular response in convalescent COVID-19 lupus patients

(2022) Cristina Solé et al.   Scientific Reports

Profile of specific and associated autoantibodies in patients with idiopathic inflammatory myopathies in a Colombian population

(2022) Andrés Hormaza-Jaramillo et al.   Frontiers in Medicine

Cardiac involvement in anti-MDA5 dermatomyositis: a case-based review

(2022) Diana C. Quintero-González et al.   CLINICAL RHEUMATOLOGY

TRIM21‑a potential biomarker for the prognosis of thyroid cancer

(2022) Zhen Wu et al.   Experimental and Therapeutic Medicine

Target-induced clustering activates Trim-Away of pathogens and proteins

(2021) Jingwei Zeng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

(2021) Wenqing Gao et al.   CELL DEATH AND DIFFERENTIATION

A functional assay for serum detection of antibodies against SARS‐CoV‐2 nucleoprotein

(2021) Anna Albecka et al.   EMBO JOURNAL

TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease

(2021) Esther L. Jones et al.   Frontiers in Immunology

TRIM21 improves apatinib treatment in gastric cancer through suppressing EZH1 stability

(2021) Mei Ping et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-TRIM21 antibody is associated with aberrant B-cell function and type I interferon production in systemic lupus erythematosus

(2021) Yosuke Kunishita et al.   LUPUS

An updated review of anti-Ro52 (TRIM21) antibodies impact in connective tissue diseases clinical management

(2021) P. Decker et al.   AUTOIMMUNITY REVIEWS

Anti-Ro52 antibodies are a risk factor for interstitial lung disease in primary Sjögren syndrome

(2020) Charlotte Buvry et al.   RESPIRATORY MEDICINE

TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis

(2020) Yosuke Kunishita et al.   Frontiers in Immunology

Interferon regulatory factor 8 governs myeloid cell development

(2020) Xueli Xia et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

(2020) Dorian Parisis et al.   Journal of Clinical Medicine

Anti‐Ro52 antibodies in clinical practice: A single‐centre experience

(2020) Si Wu et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Clinical characteristics and prognostic analysis of Chinese dermatomyositis patients with malignancies

(2020) Chi Shao et al.   MEDICINE

Anti-Ro52 antibody is an independent risk factor for interstitial lung disease in dermatomyositis

(2020) Xiaojing Xing et al.   RESPIRATORY MEDICINE

Autoantibodies are present before the clinical diagnosis of systemic sclerosis

(2019) Peter D. Burbelo et al.   PLoS One

Muscular and extramuscular features of myositis patients with anti-U1-RNP autoantibodies

(2019) Maria Casal-Dominguez et al.   NEUROLOGY

Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis

(2019) Sara Sabbagh et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical significance of myositis-specific autoantibody profiles in Japanese patients with polymyositis/dermatomyositis

(2019) Jumpei Temmoku et al.   MEDICINE

Clinical characteristics of dermatomyositis patients with isolated anti-Ro-52 antibody associated rapid progressive interstitial lung disease: Data from the largest single Chinese center

(2019) Fang Chen et al.   RESPIRATORY MEDICINE

TRIM21—From Intracellular Immunity to Therapy

(2019) Stian Foss et al.   Frontiers in Immunology

Longitudinal anti‐nuclear antibody (ANA) seroconversion in systemic lupus erythematosus: a prospective study of Swedish cases with recent‐onset disease

(2019) M. Frodlund et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus

(2018) Reikou Kamiyama et al.   Modern Rheumatology

Myositis autoantibody profiles and their clinical associations in Greek patients with inflammatory myopathies

(2018) Evangelia Zampeli et al.   CLINICAL RHEUMATOLOGY

Advances and challenges in targeting IRF5, a key regulator of inflammation

(2018) Hannah Almuttaqi et al.   FEBS Journal

Immune Response Targeting Sjögren’s Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice

(2018) Marta Trzeciak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model

(2017) Hanne Vinter et al.   EXPERIMENTAL DERMATOLOGY

Clinical & immunological characteristics in systemic lupus erythematosus patients

(2017) Maryam Rastin et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Clinical associations of the positive anti Ro52 without Ro60 autoantibodies: undifferentiated connective tissue diseases

(2017) Sai H K Murng et al.   JOURNAL OF CLINICAL PATHOLOGY

Clinical Profiles and Prognosis of Patients with Distinct Antisynthetase Autoantibodies

(2017) Jingli Shi et al.   JOURNAL OF RHEUMATOLOGY

Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain

(2017) Amélie Wallenhammar et al.   PLoS One

A review of the role and clinical utility of anti-Ro52/TRIM21 in systemic autoimmunity

(2017) Adrian Y. S. Lee   RHEUMATOLOGY INTERNATIONAL

Prediction and Prevention of Autoimmune Disease in the 21st Century: A Review and Preview

(2016) Noel R. Rose   AMERICAN JOURNAL OF EPIDEMIOLOGY

Rituximab in the Treatment of Jo1 Antibody-associated Antisynthetase Syndrome: Anti-Ro52 Positivity as a Marker for Severity and Treatment Response

(2016) J. Bauhammer et al.   JOURNAL OF RHEUMATOLOGY

Anti-Ro/SSA antibodies are associated with severe mitral valve regurgitation in patients with systemic lupus erythematosus

(2016) Violeta Higuera-Ortiz et al.   Modern Rheumatology

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice

(2015) Barbara M Szczerba et al.   ANNALS OF THE RHEUMATIC DISEASES

Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease

(2015) S. Brauner et al.   JOURNAL OF INTERNAL MEDICINE

Human autoimmune diseases: a comprehensive update

(2015) Lifeng Wang et al.   JOURNAL OF INTERNAL MEDICINE

Clinical subsets associated with different anti-aminoacyl transfer RNA synthetase antibodies and their association with coexisting anti-Ro52

(2015) Yoshioki Yamasaki et al.   Modern Rheumatology

Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease

(2015) Ragnar Gunnarsson et al.   RHEUMATOLOGY

Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjögren's syndrome

(2014) L. A. Aqrawi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway

(2014) N. C. Kyriakidis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies

(2014) Christie Fitch-Rogalsky et al.   PLoS One

Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis

(2013) MG Cruellas et al.   Clinics

Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupus

(2013) M Kvarnström et al.   LUPUS

Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

(2013) Aurora Menéndez et al.   TheScientificWorldJOURNAL

Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies: Diagnostic utility of their separate detection

(2012) Aurora Menéndez et al.   AUTOIMMUNITY

Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis

(2012) Danilo Villalta et al.   AUTOIMMUNITY REVIEWS

The immunobiology of Ro52 (TRIM21) in autoimmunity: A critical review

(2012) Vilija Oke et al.   JOURNAL OF AUTOIMMUNITY

Two Major Autoantibody Clusters in Systemic Lupus Erythematosus

(2012) Kathryn H. Ching et al.   PLoS One

Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis

(2012) Marie Hudson et al.   ARTHRITIS RESEARCH & THERAPY

Clinical significance of anti-Ro52 (TRIM21) antibodies non-associated with anti-SSA 60kDa antibodies: Results of a multicentric study

(2011) P. Ghillani et al.   AUTOIMMUNITY REVIEWS

SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

(2011) Siti Nur Aisyah Jauharoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Prognostic implications of antibodies to Ro/SSA and soluble liver antigen in type 1 autoimmune hepatitis

(2011) Aldo J. Montano-Loza et al.   LIVER INTERNATIONAL

The prevalence and the clinical relevance of anti-Ro52 in Korean patients with primary Sjögren’s syndrome

(2011) Jung-Soo Song et al.   RHEUMATOLOGY INTERNATIONAL

Sera from patients with rheumatic diseases recognize different epitope regions on the 52-kD Ro/SS-A protein

(2010) B. BOŽIČ et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

(2010) Rowan Higgs et al.   PLoS One

Diagnostic utility of anti-Ro52 detection in systemic autoimmunity

(2010) M. Dugar et al.   POSTGRADUATE MEDICAL JOURNAL

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Ro52 Expression in Spontaneous and UV-Induced Cutaneous Inflammation

(2009) Vilija Oke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY