TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model

Aldara®-induced skin inflammation: studies of patients with psoriasis

(2014) H. Vinter et al.   BRITISH JOURNAL OF DERMATOLOGY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

(2014) Elisa Lazzari et al.   PLoS One

Trim21: a novel negative regulator in DNA sensor signaling

(2013) Bo Yang et al.   Cellular & Molecular Immunology

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNFα- and IL-17A-mediated S100A8 expression is regulated by p38 MAPK

(2013) Maike Mose et al.   EXPERIMENTAL DERMATOLOGY

Aldara activates TLR7-independent immune defence

(2013) Anne Walter et al.   Nature Communications

Estrogen Receptor α Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus

(2013) Siobhán Smith et al.   Arthritis & Rheumatology

The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice

(2010) Trine Bertelsen et al.   EXPERIMENTAL DERMATOLOGY

Fas-associated Death Domain (FADD) and the E3 Ubiquitin-Protein Ligase TRIM21 Interact to Negatively Regulate Virus-induced Interferon Production

(2010) Jennifer A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

(2010) Rowan Higgs et al.   PLoS One

Comorbidities in Patients with Psoriasis

(2009) Alice B. Gottlieb et al.   AMERICAN JOURNAL OF MEDICINE

Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice: Figure 1.

(2009) Silvia Bolland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF- B-Dependent Cytokine Expression in Fibroblasts

(2009) R. Yoshimi et al.   JOURNAL OF IMMUNOLOGY

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases

(2008) Rasmus Boye Kjellerup et al.   EXPERIMENTAL DERMATOLOGY