SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway

L1CAM promotes vasculogenic mimicry formation by miR ‐143‐3p‐induced expression of hexokinase 2 in glioma

(2023) Yishan Huang et al.   Molecular Oncology

SUMOylation-mediated PSME3-20 S proteasomal degradation of transcription factor CP2c is crucial for cell cycle progression

(2023) Seung Han Son et al.   Science Advances

Pathological angiogenesis: mechanisms and therapeutic strategies

(2023) Andrew C. Dudley et al.   ANGIOGENESIS

SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS

(2023) Xiaohu Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia

(2023) Qindong Guo et al.   Cell Death & Disease

Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2

(2023) Rui Li et al.   Nature Communications

FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer

(2022) Yufei Long et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis

(2022) Kun Cai et al.   Cell Death & Disease

New Directions in the Therapy of Glioblastoma

(2022) Katarzyna Szklener et al.   Cancers

SUMOylation of TUFT1 is essential for gastric cancer progression through AKT / mTOR signaling pathway activation

(2022) Tianning Wang et al.   CANCER SCIENCE

SMARCC2 mediates the regulation of DKK1 by the transcription factor EGR1 through chromatin remodeling to reduce the proliferative capacity of glioblastoma

(2022) Chiyang Li et al.   Cell Death & Disease

Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway

(2021) Xiaoshu Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

(2021) Xia Wang et al.   Nature Communications

FOXD1 regulates cell division in clear cell renal cell carcinoma

(2021) Kyle H. Bond et al.   BMC CANCER

COE Inhibits Vasculogenic Mimicry by Targeting EphA2 in Hepatocellular Carcinoma, a Research Based on Proteomics Analysis

(2021) Zewen Chu et al.   Frontiers in Pharmacology

Hypoxia: The Cornerstone of Glioblastoma

(2021) Marta Domènech et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells

(2021) Guoxi Zhang et al.   Cell Death & Disease

RALY may cause an aggressive biological behavior and a dismal prognosis in non-small-cell lung cancer

(2020) Guanchu Song et al.   EXPERIMENTAL CELL RESEARCH

FOXD1 Repression Potentiates Radiation Effectiveness by Downregulating G3BP2 Expression and Promoting the Activation of TXNIP-Related Pathways in Oral Cancer

(2020) Che-Hsuan Lin et al.   Cancers

Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes

(2020) Cuicui Wang et al.   JCI Insight

Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma

(2020) Shuwei Chen et al.   CANCER LETTERS

Mechanisms of Vasculogenic Mimicry in Ovarian Cancer

(2019) Lízbeth Ayala-Domínguez et al.   Frontiers in Oncology

Vasculogenic Mimicry: Become an Endothelial Cell “But Not So Much”

(2019) Mónica Fernández-Cortés et al.   Frontiers in Oncology

The multisystemic functions of FOXD1 in development and disease

(2018) Paula Quintero-Ronderos et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Primary brain tumours in adults

(2018) Sarah Lapointe et al.   LANCET

SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes

(2018) Xiaolan Zhao   MOLECULAR CELL

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

(2018) Zongyang Lv et al.   Nature Communications

RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells

(2017) Emma Bondy-Chorney et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The hnRNP RALY regulates transcription and cell proliferation by modulating the expression of specific factors including the proliferation marker E2F1

(2017) Nicola Cornella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma

(2017) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications

(2017) Tathiane M Malta et al.   NEURO-ONCOLOGY

Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes

(2017) Annalisa Rossi et al.   NUCLEIC ACIDS RESEARCH

Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells

(2017) Yuan-Feng Gao et al.   ONCOLOGY REPORTS

FOXD1–ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells

(2016) Peng Cheng et al.   CANCER RESEARCH

Dickkopf-1-promoted vasculogenic mimicry in non-small cell lung cancer is associated with EMT and development of a cancer stem-like cell phenotype

(2016) Lingli Yao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer

(2015) Xiaoke Liu et al.   Journal of Hematology & Oncology

Functional Proteomics Study Reveals SUMOylation of TFII-I is Involved in Liver Cancer Cell Proliferation

(2015) Jun Tu et al.   JOURNAL OF PROTEOME RESEARCH

Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development

(2015) Rong Deng et al.   Oncotarget

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1

(2014) Yingying Qu et al.   Molecular Cancer

SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression

(2014) Anita C. Bellail et al.   Nature Communications

DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway

(2013) Liang Chen et al.   Molecular Cancer

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

(2012) Seong Won Lee et al.   EMBO JOURNAL

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

(2012) Marco Reis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

PIAS proteins: pleiotropic interactors associated with SUMO

(2009) Miia M. Rytinki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

(2008) Edward T. H. Yeh   JOURNAL OF BIOLOGICAL CHEMISTRY