The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma

Bevacizumab changes vascular structure and modulates the expression of angiogenic factors in recurrent malignant gliomas

(2016) Saori Okamoto et al.   Brain Tumor Pathology

Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models

(2016) Yuji Piao et al.   NEURO-ONCOLOGY

Histopathological investigation of glioblastomas resected under bevacizumab treatment

(2016) Ryota Tamura et al.   Oncotarget

CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

(2016) Hadjer Abdelouahab et al.   Oncotarget

Effective treatment of glioblastoma requires crossing the blood–brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine

(2015) Sang-Soo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

(2015) Giovanni Luca Gravina et al.   BMC CANCER

Recent advance in molecular angiogenesis in glioblastoma: the challenge and hope for anti-angiogenic therapy

(2015) Meng Zhang et al.   Brain Tumor Pathology

VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner

(2015) Kien Pham et al.   CANCER LETTERS

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

(2015) A. Scholz et al.   EMBO Molecular Medicine

Impact of Timing of Concurrent Chemoradiation for Newly Diagnosed Glioblastoma

(2015) Seunggu J. Han et al.   NEUROSURGERY

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal

(2015) Valentina Lulli et al.   Oncotarget

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

(2015) Hui Xu et al.   Oncotarget

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway

(2015) Emeline Tabouret et al.   Oncotarget

Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme

(2015) Wonyoung Kang et al.   Oncotarget

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

(2015) Amy Barone et al.   Oncotarget

Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes

(2015) Konrad Gabrusiewicz et al.   Oncotarget

Combining Bevacizumab with Temozolomide Increases the Antitumor Efficacy of Temozolomide in a Human Glioblastoma Orthotopic Xenograft Model

(2015) Véronique Mathieu et al.   NEOPLASIA

Torc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models

(2014) Giovanni Luca Gravina et al.   PROSTATE

Effects of Tyrosine Kinase Inhibitors and CXCR4 Antagonist on Tumor Growth and Angiogenesis in Rat Glioma Model: MRI and Protein Analysis Study

(2014) Meser M. Ali et al.   Translational Oncology

An Orthotopic Glioblastoma Mouse Model Maintaining Brain Parenchymal Physical Constraints and Suitable for Intravital Two-photon Microscopy

(2014) Clément Ricard et al.   Jove-Journal of Visualized Experiments

Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy

(2014) Gregory J. Baker et al.   NEOPLASIA

Bone Marrow-Derived Microglia Infiltrate into the Paraventricular Nucleus of Chronic Psychological Stress-Loaded Mice

(2013) Koji Ataka et al.   PLoS One

Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity

(2013) Monica Gatti et al.   TOXICOLOGY

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Microarray Analysis Verifies Two Distinct Phenotypes of Glioblastomas Resistant to Antiangiogenic Therapy

(2012) M. DeLay et al.   CLINICAL CANCER RESEARCH

The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma

(2012) Randy D’Amico et al.   NEUROLOGICAL RESEARCH

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

VEGFR2 Expression and TGF-β Signaling in Initial and Recurrent High-Grade Human Glioma

(2011) Elizabeth A. Kuczynski et al.   ONCOLOGY

Antitumor Effect of NK012, a 7-Ethyl-10-Hydroxycamptothecin-Incorporating Polymeric Micelle, on U87MG Orthotopic Glioblastoma in Mice Compared with Irinotecan Hydrochloride in Combination with Bevacizumab

(2010) J.-i. Kuroda et al.   CLINICAL CANCER RESEARCH

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

Mediators of Glioblastoma Resistance and Invasion during Antivascular Endothelial Growth Factor Therapy

(2009) A. K. Lucio-Eterovic et al.   CLINICAL CANCER RESEARCH

Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models

(2009) Claudio Festuccia et al.   ENDOCRINE-RELATED CANCER

Discovery of Novel Non-Cyclam Polynitrogenated CXCR4 Coreceptor Inhibitors

(2008) Sofia Pettersson et al.   ChemMedChem

Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence

(2008) A. D. Norden et al.   NEUROLOGY