SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Detecting endogenous SUMO targets in mammalian cells and tissues

(2013) Janina Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMO2/3 modification of cyclin E contributes to the control of replication origin firing

(2013) Catherine Bonne-Andrea et al.   Nature Communications

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

(2012) Catherine M. Sawai et al.   CANCER CELL

Phosphorylation of Ubc9 by Cdk1 Enhances SUMOylation Activity

(2012) Yee-Fun Su et al.   PLoS One

A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma

(2012) Anita C. Bellail et al.   Cancer Discovery

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

(2011) Yuji Kubota et al.   NATURE CELL BIOLOGY

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

SnapShot: The SUMO System

(2010) Sandrine Creton et al.   CELL

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

(2010) W. R. Wiedemeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis

(2009) M. G. Hu et al.   CANCER RESEARCH

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression

(2009) Xue-Ming Xu et al.   Nature Protocols

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY