Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2

Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina

(2022) Françoise Helmbacher   DEVELOPMENT

STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

(2021) Ying Shen et al.   Science Signaling

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187

(2020) Zhonghao Wang et al.   Oncogenesis

The Lipopeptide MALP-2 Promotes Collateral Growth

(2020) Kerstin Troidl et al.   Cells

The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling

(2020) Athanasios Pseftogas et al.   Cancers

Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction

(2020) Min Fan et al.   JCI Insight

A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

(2020) Masashi Watanabe et al.   Communications Biology

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

(2020) Ievgenia Pastushenko et al.   NATURE

YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility

(2019) Devon E. Mason et al.   JOURNAL OF CELL BIOLOGY

TAK1 regulates endothelial cell necroptosis and tumor metastasis

(2019) Lida Yang et al.   CELL DEATH AND DIFFERENTIATION

MARMoSET – Extracting Publication-Ready Mass Spectrometry Metadata from RAW Files

(2019) Marina Kiweler et al.   MOLECULAR & CELLULAR PROTEOMICS

The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD

(2019) Atsushi Uematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Lysophosphatidic acid–induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4

(2019) Daisuke Yasuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial CellsNovelty and Significance

(2018) Jinlong He et al.   CIRCULATION RESEARCH

Big roles for Fat cadherins

(2018) Seth Blair et al.   CURRENT OPINION IN CELL BIOLOGY

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

(2018) Fan Yao et al.   Nature Communications

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

(2018) T. Azad et al.   Nature Communications

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

(2018) Daniel Martin et al.   Nature Communications

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

(2018) Rebecca Feltham et al.   Cell Reports

Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis

(2018) Françoise Helmbacher   PLOS BIOLOGY

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

(2018) Filipa Neto et al.   eLife

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway

(2018) Zhiqiang Li et al.   CANCER CELL

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP/TAZ-CDC42 signaling regulates vascular tip cell migration

(2017) Masahide Sakabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Hippo Pathway Transcription Factor TEAD

(2017) Kimberly C. Lin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Systematic approaches to identify E3 ligase substrates

(2016) M. Iconomou et al.   BIOCHEMICAL JOURNAL

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in MiceNovelty and Significance

(2016) Harmandeep Kaur et al.   CIRCULATION RESEARCH

Control of mitochondrial function and cell growth by the atypical cadherin Fat1

(2016) Longyue L. Cao et al.   NATURE

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FAT1 mutations cause a glomerulotubular nephropathy

(2016) Heon Yung Gee et al.   Nature Communications

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation

(2015) Abdulrzag F. Ahmed et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

(2015) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

(2015) Hyun-Jung Choi et al.   Nature Communications

Sensing the local environment: actin architecture and Hippo signalling

(2014) Pedro Gaspar et al.   CURRENT OPINION IN CELL BIOLOGY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma

(2014) Kangsheng Tu et al.   Molecular Cancer

G13 Controls Angiogenesis through Regulation of VEGFR-2 Expression

(2013) Kishor Kumar Sivaraj et al.   DEVELOPMENTAL CELL

Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease

(2013) Elham Sadeqzadeh et al.   MEDICINAL RESEARCH REVIEWS

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

(2013) Luc G T Morris et al.   NATURE GENETICS

An evolutionary shift in the regulation of the Hippo pathway between mice and flies

(2013) W Bossuyt et al.   ONCOGENE

Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy

(2013) Nathalie Caruso et al.   PLoS Genetics

Function and cancer genomics of FAT family genes

(2012) MASARU KATOH   INTERNATIONAL JOURNAL OF ONCOLOGY

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

(2012) Wei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

MIQuant – Semi-Automation of Infarct Size Assessment in Models of Cardiac Ischemic Injury

(2011) Diana S. Nascimento et al.   PLoS One

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

Adrenomedullin ameliorates the development of atherosclerosis in apoE−/− mice

(2010) Chun Shui Pan et al.   PEPTIDES

Both TEAD-Binding and WW Domains Are Required for the Growth Stimulation and Oncogenic Transformation Activity of Yes-Associated Protein

(2009) B. Zhao et al.   CANCER RESEARCH

Anaphylactic shock depends on endothelial Gq/G11

(2009) Hanna Korhonen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY