Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes

The role of protein SUMOylation in rheumatoid arthritis

(2019) Sajad Dehnavi et al.   JOURNAL OF AUTOIMMUNITY

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

(2019) Patricia Gnieslaw de Oliveira et al.   Frontiers in Immunology

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

(2018) Jane Falconer et al.   Arthritis & Rheumatology

SUMOs Mediate the Nuclear Transfer of p38 and p-p38 during Helicobacter Pylori Infection

(2018) Pin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation

(2018) Yaoyao Zou et al.   JOURNAL OF CLINICAL INVESTIGATION

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis

(2018) Xiaoyue Zhao et al.   Scientific Reports

Cell metabolism as a potentially targetable pathway in RA

(2018) Trudy McGarry et al.   Nature Reviews Rheumatology

Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

(2018) Fang Liu et al.   Frontiers in Immunology

Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2018) Minxi Lao et al.   EXPERIMENTAL CELL RESEARCH

STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells

(2017) So Hee Dho et al.   EXPERIMENTAL CELL RESEARCH

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolomics in rheumatic diseases: desperately seeking biomarkers

(2016) Monica Guma et al.   Nature Reviews Rheumatology

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation

(2016) Jose C. Alves-Filho et al.   Frontiers in Immunology

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

(2015) Minxi Lao et al.   JOURNAL OF IMMUNOLOGY

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

(2014) A. Hoellein et al.   BLOOD

SUMO-Conjugating Enzyme UBC9 Promotes Proliferation and Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

(2014) Faxin Li et al.   INFLAMMATION

Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics

(2014) Ponnusamy Kalaiarasan et al.   JOURNAL OF MOLECULAR MODELING

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells

(2014) Yuhui Jiang et al.   Nature Communications

Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB

(2013) Svetlana Frank et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression

(2010) Hanna Maciejewska-Rodrigues et al.   JOURNAL OF AUTOIMMUNITY

Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia

(2010) Terence A. Agbor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modification by SUMO

(2010) Zara Hannoun et al.   TOXICOLOGY

The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2

(2009) Gilles A. Spoden et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Systematic study of protein sumoylation: Development of a site-specific predictor of SUMOsp 2.0

(2009) Jian Ren et al.   PROTEOMICS

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

(2008) Edward T. H. Yeh   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE