The local microenvironment drives activation of neutrophils in human brain tumors

Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors

(2023) Ángel F. Álvarez-Prado et al.   Cell Reports Medicine

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy

(2023) Yun Chang et al.   Nature Communications

Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation

(2023) Vladimir Wischnewski et al.   Nature Cancer

Cellular architecture of human brain metastases

(2022) Hugo Gonzalez et al.   CELL

Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study

(2022) Carine Jiguet-Jiglaire et al.   Acta Neuropathologica Communications

Neutrophil phenotypes and functions in cancer: A consensus statement

(2022) Daniela F. Quail et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multispectral fluorine-19 MRI enables longitudinal and noninvasive monitoring of tumor-associated macrophages

(2022) Davide Croci et al.   Science Translational Medicine

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

(2022) Stefan Salcher et al.   CANCER CELL

Liver tumour immune microenvironment subtypes and neutrophil heterogeneity

(2022) Ruidong Xue et al.   NATURE

Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases

(2021) Angelika M. Starzer et al.   BRITISH JOURNAL OF CANCER

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

(2021) Yansen Xiao et al.   CANCER CELL

Tumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spread

(2021) Zhenzi Peng et al.   OncoImmunology

Twelve years of SAMtools and BCFtools

(2021) Petr Danecek et al.   GigaScience

Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental animal model of sepsis

(2021) Jia-feng Wang et al.   BLOOD

An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples

(2021) Roeltje R. Maas et al.   Nature Protocols

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

(2021) David N Louis et al.   NEURO-ONCOLOGY

Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

(2021) Rósula García-Navas et al.   Scientific Reports

Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow

(2021) Prerna Magod et al.   Cell Reports

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

(2021) Yan-mei Qiu et al.   Frontiers in Immunology

Immunotherapy in Glioblastoma: A Clinical Perspective

(2021) Nicolas Desbaillets et al.   Cancers

Activated neutrophils polarize protumorigenic interleukin‐17A‐producing T helper subsets through TNF‐α‐B7‐H2‐dependent pathway in human gastric cancer

(2021) Zhi‐guo Shan et al.   Clinical and Translational Medicine

Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline

(2021) Nimish A. Mohile et al.   JOURNAL OF CLINICAL ONCOLOGY

Neutrophil metabolism in the cancer context

(2021) Anita Bodac et al.   SEMINARS IN IMMUNOLOGY

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

(2020) Ekaterina Friebel et al.   CELL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Pre-stereotactic radiosurgery neutrophil-to-lymphocyte ratio is a predictor of the prognosis for brain metastases

(2020) Lifeng Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial

(2020) Sarah B Goldberg et al.   LANCET ONCOLOGY

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

(2020) Lin Zhang et al.   Science Translational Medicine

The role of neutrophil death in chronic inflammation and cancer

(2020) Christine Brostjan et al.   Cell Death Discovery

Co-option of Neutrophil Fates by Tissue Environments

(2020) Iván Ballesteros et al.   CELL

Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient

(2020) Paul W. Sperduto et al.   JOURNAL OF CLINICAL ONCOLOGY

Breast Cancer Cell–Neutrophil Interactions Enhance Neutrophil Survival and Pro-Tumorigenic Activities

(2020) Lingyun Wu et al.   Cancers

Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

(2020) Meghan A. Cupp et al.   BMC Medicine

Brain metastases

(2019) Achal Singh Achrol et al.   Nature Reviews Disease Primers

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro

(2019) Anjana Ajikumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Matrix Metalloproteinases in Angiogenesis and Cancer

(2019) Saray Quintero-Fabián et al.   Frontiers in Oncology

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells

(2018) Maya Gershkovitz et al.   CANCER RESEARCH

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

(2018) Sofia Mensurado et al.   PLOS BIOLOGY

S100A8/A9 in Inflammation

(2018) Siwen Wang et al.   Frontiers in Immunology

Fine Regulation of Neutrophil Oxidative Status and Apoptosis by Ceruloplasmin and Its Derivatives

(2018) Ekaterina Golenkina et al.   Cells

Multiplexed protein maps link subcellular organization to cellular states

(2018) Gabriele Gut et al.   SCIENCE

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

(2017) Ting-ting Wang et al.   GUT

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

(2017) Nicole Glodde et al.   IMMUNITY

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF

(2016) Tsuguhide Takeshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging: A Temporal Dimension for Neutrophils

(2016) José M. Adrover et al.   TRENDS IN IMMUNOLOGY

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma

(2014) Tatsuya Ozawa et al.   CANCER CELL

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Modeling Adult Gliomas Using RCAS/t-va Technology

(2014) Dolores Hambardzumyan et al.   Translational Oncology

Neutrophils Promote the Malignant Glioma Phenotype through S100A4

(2013) J. Liang et al.   CLINICAL CANCER RESEARCH

Ceruloplasmin Is an Endogenous Inhibitor of Myeloperoxidase

(2013) Anna L. P. Chapman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Premetastatic soil and prevention of breast cancer brain metastasis

(2013) Y. Liu et al.   NEURO-ONCOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A crucial role for TNF-α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5

(2009) SM Vieira et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas

(2008) O. J. Becher et al.   CANCER RESEARCH

Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease

(2008) E. Fortunati et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY