CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy

Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells

(2022) Yun Chang et al.   BIOMATERIALS

Mechanism-based design of agents that selectively target drug-resistant glioma

(2022) Kingson Lin et al.   SCIENCE

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

(2022) Yun Chang et al.   Cell Reports

Chemically defined generation of human definitive hematopoietic stem and progenitor cells

(2022) Juhyung Jung et al.   STAR Protocols

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

(2021) Asieh Emami Nejad et al.   Cancer Cell International

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

(2021) Giulia Agliardi et al.   Nature Communications

Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing IL-12, in pet dogs with sporadic gliomas

(2021) Nidal B. Omar et al.   Neurosurgical Focus

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

(2021) Erik Jung et al.   Nature Communications

Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

(2021) Bo Wang et al.   Nature Biomedical Engineering

A Tumor‐Microenvironment‐Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal‐Enhanced Enzyme Dynamic Therapy

(2021) Bin Liu et al.   ADVANCED MATERIALS

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

(2021) Yuping Fan et al.   Science Translational Medicine

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

(2021) Fan Yang et al.   Nature Communications

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells

(2021) Yoo-Wook Kwon et al.   Stem Cells International

Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma

(2021) Xiangyu Li et al.   Frontiers in Pharmacology

Roles of Neutrophils in Glioma and Brain Metastases

(2021) Ya-Jui Lin et al.   Frontiers in Immunology

Neutrophils as an emerging therapeutic target and tool for cancer therapy

(2021) Md Abdus Subhan et al.   LIFE SCIENCES

Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach

(2020) Yi-Hsien Cheng et al.   ACS Nano

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

(2020) Dongrui Wang et al.   Science Translational Medicine

Fluorescent indicators for continuous and lineage‐specific reporting of cell‐cycle phases in human pluripotent stem cells

(2020) Yun Chang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy

(2020) Gavin P Dunn et al.   NEURO-ONCOLOGY

Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases

(2020) Hanieh Safari et al.   Science Advances

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

(2020) Gloria B. Kim et al.   Bioactive Materials

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

(2019) Audrey LEQUEUX et al.   CANCER LETTERS

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAR T cells for brain tumors: Lessons learned and road ahead

(2019) David Akhavan et al.   IMMUNOLOGICAL REVIEWS

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

(2019) Yong Gu Lee et al.   Nature Communications

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Expression, Role, and Regulation of Neutrophil Fcγ Receptors

(2019) Yu Wang et al.   Frontiers in Immunology

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils

(2019) Karim Mahiddine et al.   JOURNAL OF CLINICAL INVESTIGATION

Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA

(2019) Vera S. Brok-Volchanskaya et al.   Stem Cell Reports

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

(2018) Yuki Kagoya et al.   NATURE MEDICINE

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell‐Induced Severe or Life‐Threatening Cytokine Release Syndrome

(2018) Robert Q. Le et al.   ONCOLOGIST

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

(2018) Meiying Wu et al.   Nature Communications

Immune microenvironment of gliomas

(2017) Anna Gieryng et al.   LABORATORY INVESTIGATION

Cancer therapy: Neutrophils traffic in cancer nanodrugs

(2017) Satoru Osuka et al.   Nature Nanotechnology

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

(2017) Giang T. Nguyen et al.   Frontiers in Cellular and Infection Microbiology

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

(2015) Adam Blaisdell et al.   CANCER CELL

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells

(2014) Jun Yan et al.   OncoImmunology

Neutrophils Promote the Malignant Glioma Phenotype through S100A4

(2013) J. Liang et al.   CLINICAL CANCER RESEARCH

A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Rα2 tumor-restricted biomarker

(2012) Van Nguyen et al.   NEURO-ONCOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Human Neutrophil Fcγ Receptors Initiate and Play Specialized Nonredundant Roles in Antibody-Mediated Inflammatory Diseases

(2008) Naotake Tsuboi et al.   IMMUNITY