Mitochondria and telomeres: hand in glove

Hallmarks of aging: An expanding universe

(2023) Carlos López-Otín et al.   CELL

Does oxidative stress shorten telomeres in vivo? A meta-analysis

(2023) Emma Armstrong et al.   AGEING RESEARCH REVIEWS

TERT Extra-Telomeric Roles: Antioxidant Activity and Mitochondrial Protection

(2023) Jessica Marinaccio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo

(2023) Amanda J. Stock et al.   GeroScience

Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis

(2023) Hiroshi Ebata et al.   FEBS Open Bio

Variability in newborn telomere length is explained by inheritance and intrauterine environment

(2022) Li Chen et al.   BMC Medicine

Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening

(2022) Ryan P. Barnes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle

(2021) Samantha L. Sanford et al.   DNA REPAIR

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

(2021) Annie A. Demin et al.   MOLECULAR CELL

Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells

(2021) Ling Wang et al.   AGING CELL

Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress

(2021) Mariarosaria De Rosa et al.   Frontiers in Cell and Developmental Biology

Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension

(2020) Hui-Ting Lee et al.   BIOCHEMISTRY

Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1

(2020) Woo Hyun Shin et al.   Cell Death & Disease

Mitochondrial Electron Transport: Oxidative Phosphorylation, Mitochondrial Oxidant Production, and Methods of Measurement

(2020) Deirdre Nolfi-Donegan et al.   Redox Biology

Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction

(2020) Chongkui Sun et al.   EMBO JOURNAL

Telomerase reverse transcriptase downregulation by RNA interference modulates endoplasmic reticulum stress and mitochondrial energy production

(2020) Muhammad Zuhair Mohd Zain et al.   MOLECULAR BIOLOGY REPORTS

Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

(2020) Samantha L. Sanford et al.   Nature Communications

Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

(2019) Elisa Coluzzi et al.   Cells

Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy

(2019) Paula Green et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

(2019) Ru‑Zhou Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

(2019) Elise Fouquerel et al.   MOLECULAR CELL

Genetically Increased Telomere Length and Aging-Related Traits in the U.K. Biobank

(2019) Kathryn Demanelis et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Telomerase Does Not Improve DNA Repair in Mitochondria upon Stress but Increases MnSOD Protein under Serum-Free Conditions

(2019) Alexander Martens et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of oxidative stress on telomere biology

(2018) Wareed Ahmed et al.   DIFFERENTIATION

PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase

(2018) Wareed Ahmed et al.   GENES & DEVELOPMENT

The impact of oxidative DNA damage and stress on telomere homeostasis

(2018) Ryan P. Barnes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Mitochondrial Trafficking and Processing of Telomerase RNA TERC

(2018) Ying Cheng et al.   Cell Reports

Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

(2017) Hui-Ting Lee et al.   NUCLEIC ACIDS RESEARCH

Oxidative guanine base damage regulates human telomerase activity

(2016) Elise Fouquerel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oxidative guanine base damage regulates human telomerase activity

(2016) Elise Fouquerel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

(2016) Eric Aeby et al.   Cell Reports

Mitochondrial DNA Variation in Human Radiation and Disease

(2015) Douglas C. Wallace   CELL

Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death

(2015) Luxi Sun et al.   NUCLEIC ACIDS RESEARCH

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Maternal and genetic factors determine early life telomere length

(2014) M. Asghar et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

(2013) Linda Broer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

(2013) Chatchawan Singhapol et al.   PLoS One

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation

(2011) Marina Mattiussi et al.   CELLULAR SIGNALLING

Ageing theories unified

(2011) Daniel P. Kelly   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Mitochondria and telomeres come together

(2011) Rachel David   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

(2011) Nilesh K. Sharma et al.   NUCLEIC ACIDS RESEARCH

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

(2010) Cynthia A. Massaad et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE