XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

Mammalian DNA base excision repair: Dancing in the moonlight

(2020) Keith W. Caldecott   DNA REPAIR

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

(2020) Zhengping Shao et al.   NUCLEIC ACIDS RESEARCH

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

(2019) Luis M. Polo et al.   Cell Reports

Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism

(2019) William A. Beard et al.   Annual Review of Biochemistry

Mutations in XRCC1 cause cerebellar ataxia and peripheral neuropathy

(2018) Emer O’Connor et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair

(2017) Claire Breslin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

(2017) Masataka Tsuda et al.   PLoS One

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib

(2016) Dominic I. James et al.   ACS Chemical Biology

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

(2016) Nicolas C. Hoch et al.   NATURE

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

(2016) Gabrielle J. Grundy et al.   Nature Communications

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

(2015) Claire Breslin et al.   NUCLEIC ACIDS RESEARCH

Protein ADP-ribosylation and the cellular response to DNA strand breaks

(2014) K.W. Caldecott   DNA REPAIR

Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition

(2014) Julie K. Horton et al.   MOLECULAR CANCER RESEARCH

Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair

(2014) Rajendra Prasad et al.   NUCLEIC ACIDS RESEARCH

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

(2010) Rajendra Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA 3'-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress

(2009) C. Breslin et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

CHIP-Mediated Degradation and DNA Damage-Dependent Stabilization Regulate Base Excision Repair Proteins

(2008) Jason L. Parsons et al.   MOLECULAR CELL