Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

Linking replication stress with heterochromatin formation

(2015) Ivaylo Nikolov et al.   CHROMOSOMA

Oxidative stress alters global histone modification and DNA methylation

(2015) Yingmei Niu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Replicating through telomeres: a means to an end

(2015) Paula Martínez et al.   TRENDS IN BIOCHEMICAL SCIENCES

Histone lysine methylation and chromatin replication

(2014) Carlos Rivera et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair

(2014) Charlène Lemaître et al.   DNA REPAIR

Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells

(2014) Elisa Coluzzi et al.   PLoS One

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The causes of replication stress and their consequences on genome stability and cell fate

(2014) Indiana Magdalou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Telomere shortening and telomere position effect in mild ring 17 syndrome

(2014) Cecilia Surace et al.   Epigenetics & Chromatin

Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions

(2014) Cristina Bartocci et al.   Cell Reports

Reactive Oxygen Species Induce Epigenetic Instability through the Formation of 8-Hydroxydeoxyguanosine in Human Hepatocarcinogenesis

(2013) Naoshi Nishida et al.   DIGESTIVE DISEASES

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

(2012) Peili Gu et al.   EMBO JOURNAL

Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma

(2012) Naoshi Nishida et al.   HEPATOLOGY

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

(2011) Mikel Zaratiegui et al.   NATURE

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient Activation of the ALT Pathway in Human Primary Fibroblasts Exposed to High-LET Radiation

(2010) F. Berardinelli et al.   RADIATION RESEARCH

Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear Localization

(2010) Nausica Arnoult et al.   PLoS Genetics

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Mild ring 17 syndrome shares common phenotypic features irrespective of the chromosomal breakpoints location

(2009) C Surace et al.   CLINICAL GENETICS

Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand

(2009) N. Arnoult et al.   CYTOGENETIC AND GENOME RESEARCH

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

Epigenetic inheritance during the cell cycle

(2009) Aline V. Probst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

RNA Interference Guides Histone Modification during the S Phase of Chromosomal Replication

(2008) Anna Kloc et al.   CURRENT BIOLOGY

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Telomeric position effect: From the yeast paradigm to human pathologies?

(2007) Alexandre Ottaviani et al.   BIOCHIMIE