Roles of Protein S-Nitrosylation in Endothelial Homeostasis and Dysfunction

Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation

(2022) Mengping Jia et al.   CIRCULATION RESEARCH

Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis

(2022) Shuang Zhao et al.   Redox Biology

The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response

(2022) Ancheng Zheng et al.   Frontiers in Immunology

bFGF alleviates diabetes-associated endothelial impairment by downregulating inflammation via S-nitrosylation pathway

(2021) Gen Chen et al.   Redox Biology

Insulin resistance, cardiovascular stiffening and cardiovascular disease

(2021) Michael A. Hill et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

(2021) Henry Jay Forman et al.   NATURE REVIEWS DRUG DISCOVERY

S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis

(2021) Meng-Lin Chao et al.   Nature Communications

S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3β signaling

(2021) Shuang Zhao et al.   ACTA PHARMACOLOGICA SINICA

TNF-α-activated eNOS signaling increases leukocyte adhesion through the S-nitrosylation pathway

(2021) Gaynor Aguilar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders

(2021) Anne Abot et al.   ANTIOXIDANTS & REDOX SIGNALING

Interplay between reactive oxygen and nitrogen species in living organisms

(2021) Volodymyr I. Lushchak et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The manifold roles of protein S-nitrosylation in the life of insulin

(2021) Hua-Lin Zhou et al.   Nature Reviews Endocrinology

The role of NADPH oxidases in infectious and inflammatory diseases

(2021) Jared P. Taylor et al.   Redox Biology

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Interplay between platelets and coagulation

(2020) Yaqiu Sang et al.   BLOOD REVIEWS

The protein S-nitrosylation of splicing and translational machinery in vascular endothelial cells is susceptible to oxidative stress induced by oxidized low-density lipoprotein

(2019) Xiaohui Xu et al.   Journal of Proteomics

Hippo signaling controls NLRP 3 Activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury

(2019) Changyong Li et al.   HEPATOLOGY

Vascular Endothelial Cell Biology: An Update

(2019) Krüger-Genge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AKR1A1 is a novel mammalian S-nitroso-glutathione reductase

(2019) Colin T. Stomberski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Nitrosylation of Plastin-3 Exacerbates Thoracic Aortic Dissection Formation via Endothelial Barrier Dysfunction

(2019) Lihong Pan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells

(2019) Aleksandra Kopacz et al.   Redox Biology

Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling

(2018) Colin T. Stomberski et al.   ANTIOXIDANTS & REDOX SIGNALING

eNOS S-nitrosylation mediated OxLDL-induced endothelial dysfunction via increasing the interaction of eNOS with β‑catenin

(2018) Wan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?

(2018) Matthew F. Yuyun et al.   MICROVASCULAR RESEARCH

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

(2018) Zhenlong Chen et al.   MOLECULAR BIOLOGY OF THE CELL

PTEN: Tumor Suppressor and Metabolic Regulator

(2018) Chien-Yu Chen et al.   Frontiers in Endocrinology

Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation

(2018) Roelof H. Bekendam et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury

(2018) Hua-Lin Zhou et al.   NATURE

Endothelial NO Synthase-Dependent S-Nitrosylation of β-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a

(2017) Ying Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability

(2016) Anita Guequén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extracellular Thiol Isomerases and Their Role in Thrombus Formation

(2016) Sol Schulman et al.   ANTIOXIDANTS & REDOX SIGNALING

Quantitative Proteomics Analysis of VEGF-Responsive Endothelial Protein S-Nitrosylation Using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and LC-MS/MS1

(2016) Hong-Hai Zhang et al.   BIOLOGY OF REPRODUCTION

Targeting vascular (endothelial) dysfunction

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation

(2016) Shu Meng et al.   CIRCULATION RESEARCH

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

S -nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling

(2016) Ming-Fo Hsu et al.   FREE RADICAL BIOLOGY AND MEDICINE

S -Nitrosothiols—NO donors regulating cardiovascular cell proliferation: Insight into intracellular pathway alterations

(2016) Marek Rychter et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Interaction of endothelial nitric oxide synthase with mitochondria regulates oxidative stress and function in fetal pulmonary artery endothelial cells

(2015) Girija G. Konduri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial Nitric Oxide Synthase–Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-NitrosylationSignificance

(2015) Zhejun Cai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular nitric oxide: Beyond eNOS

(2015) Yingzi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease

(2015) Ioannis Mitroulis et al.   PHARMACOLOGY & THERAPEUTICS

S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer

(2015) Stéphanie Plenchette et al.   Redox Biology

Novel regulators of endothelial barrier function

(2014) Dolly Mehta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelium-derived nitric oxide (NO) activates the NO-epidermal growth factor receptor-mediated signaling pathway in bradykinin-stimulated angiogenesis

(2014) Miriam S. Moraes et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endogenous NO Upon Estradiol-17β Stimulation and NO Donor Differentially Regulate MitochondrialS-Nitrosylation in Endothelial Cells

(2014) Seiro Satohisa et al.   ENDOCRINOLOGY

S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-Stimulated Endothelial Cell Migration

(2014) Hong-hai Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

S-Nitrosylation in Alzheimer's disease

(2014) Qing-Fei Zhao et al.   MOLECULAR NEUROBIOLOGY

Mitochondria and Endothelial Function

(2013) Matthew A. Kluge et al.   CIRCULATION RESEARCH

VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

(2013) Monica Giannotta et al.   DEVELOPMENTAL CELL

Nitric Oxide Directly Promotes Vascular Endothelial Insulin Transport

(2013) H. Wang et al.   DIABETES

Interleukin-8 Regulates Endothelial Permeability by Down-regulation of Tight Junction but not Dependent on Integrins Induced Focal Adhesions

(2013) Hongchi Yu et al.   International Journal of Biological Sciences

Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice

(2013) Hong Cui et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Korean Red Ginseng protects endothelial cells from serum-deprived apoptosis by regulating Bcl-2 family protein dynamics and caspase S-nitrosylation

(2013) Young-Mi Kim et al.   Journal of Ginseng Research

S-Nitrosoglutathione and Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Regulate Compartmentalized Ras S-Nitrosylation and Stimulate Cell Proliferation

(2012) Wagner L. Batista et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin and Thioredoxin Reductase in Relation to Reversible S-Nitrosylation

(2012) Rajib Sengupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

S-Nitrosation of β-Catenin and p120 Catenin

(2012) Natalie Marín et al.   CIRCULATION RESEARCH

Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation

(2012) Jin Qian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin

(2012) Rong-rong Tao et al.   JOURNAL OF PINEAL RESEARCH

C-reactive protein reduces protein S-nitrosylation in endothelial cells

(2012) Xinhong Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels

(2012) A. Margariti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of nitric oxide on rosuvastatin-mediated S-nitrosylation and translational proteomes in human umbilical vein endothelial cells

(2012) Bin Huang et al.   Proteome Science

Regulation of vascular guanylyl cyclase by endothelial nitric oxide-dependent posttranslational modification

(2011) Marc Oppermann et al.   BASIC RESEARCH IN CARDIOLOGY

Nitrite-Mediated S -Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction

(2011) Yen-Chun Lai et al.   CIRCULATION RESEARCH

The Biology and Therapeutic Potential of the DDAH/ADMA Pathway

(2011) F. Arrigoni et al.   CURRENT PHARMACEUTICAL DESIGN

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: Role of endothelial nitric oxide synthase and estrogen receptor-β

(2011) Hong-hai Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

(2011) Ruslan Rafikov et al.   JOURNAL OF ENDOCRINOLOGY

The G-protein-coupled estrogen receptor GPER in health and disease

(2011) Eric R. Prossnitz et al.   Nature Reviews Endocrinology

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

(2011) N. Numajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalized Connexin 43 S -Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall

(2010) Adam C. Straub et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein S -Nitrosylation and Cardioprotection

(2010) Junhui Sun et al.   CIRCULATION RESEARCH

S -Nitrosylation in Cardiovascular Signaling

(2010) Brian Lima et al.   CIRCULATION RESEARCH

Estradiol-17β Stimulates Specific Receptor and Endogenous Nitric Oxide-Dependent Dynamic Endothelial ProteinS-Nitrosylation: Analysis of EndothelialNitrosyl-Proteome

(2010) Hong-hai Zhang et al.   ENDOCRINOLOGY

Enhancement of Insulin Responsiveness by Nitric Oxide-mediated Inactivation of Protein-tyrosine Phosphatases

(2010) Ming-Fo Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

(2010) Sébastien Thibeault et al.   MOLECULAR CELL

17 -Estradiol induces protein S-nitrosylation in the endothelium

(2009) S. Chakrabarti et al.   CARDIOVASCULAR RESEARCH

Shear flow increases S-nitrosylation of proteins in endothelial cells

(2009) Bin Huang et al.   CARDIOVASCULAR RESEARCH

Mechanisms of Transendothelial Migration of Leukocytes

(2009) William A. Muller   CIRCULATION RESEARCH

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

(2009) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired integrin-mediated adhesion contributes to reduced barrier properties in VASP-deficient microvascular endothelium

(2009) Nicolas Schlegel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

S-nitrosoproteome in Endothelial Cells Revealed by a Modified Biotin Switch Approach Coupled with Western Blot-Based Two-Dimensional Gel Electrophoresis

(2009) Bin Huang et al.   JOURNAL OF PROTEOME RESEARCH

The Myoendothelial Junction: Breaking through the Matrix?

(2009) Katherine R. Heberlein et al.   MICROCIRCULATION

Ras/MAPK signaling from endomembranes

(2009) Nicole Fehrenbacher et al.   Molecular Oncology

Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production

(2009) Arthur J. Pope et al.   PHARMACOLOGICAL RESEARCH

SDF-1  stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration

(2009) X. Pi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Progenitor Cells, Endothelial Dysfunction, Inflammation, and Oxidative Stress in Hypertension

(2008) Timothy Watson et al.   ANTIOXIDANTS & REDOX SIGNALING

Acute hypoxia enhances proteins’S-nitrosylation in endothelial cells

(2008) Shih Chung Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation

(2008) Christoph Reinhardt et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

The low molecular weight S-nitrosothiol, S-nitroso-N-acetylpenicillamine, promotes cell cycle progression in rabbit aortic endothelial cells

(2008) Carlos Jorge R. Oliveira et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization

(2007) N. Schlegel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY