The manifold roles of protein S-nitrosylation in the life of insulin

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

(2021) Jun Ren et al.   Nature Reviews Cardiology

pCysMod: Prediction of Multiple Cysteine Modifications Based on Deep Learning Framework

(2021) Shihua Li et al.   Frontiers in Cell and Developmental Biology

S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein

(2020) Kana Fujikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Caveolin-1 in Diabetes and Its Complications

(2020) Dania Haddad et al.   Oxidative Medicine and Cellular Longevity

New insights into KATP channel gene mutations and neonatal diabetes mellitus

(2020) Tanadet Pipatpolkai et al.   Nature Reviews Endocrinology

Ubiquitination in the ERAD Process

(2020) Anna Lopata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic Reticulum Associated Degradation (ERAD) Has a Critical Role in Supporting Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

(2019) Yabing Hu et al.   DIABETES

Nitrosative stress drives heart failure with preserved ejection fraction

(2019) Gabriele G. Schiattarella et al.   NATURE

Endothelial cell barriers: Transport of molecules between blood and tissues

(2019) Samaneh Yazdani et al.   TRAFFIC

Genetic Associations With Diabetic Retinopathy and Coronary Artery Disease in Emirati Patients With Type-2 Diabetes Mellitus

(2019) Sarah K. Azzam et al.   Frontiers in Endocrinology

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

(2019) Rajarshi Ghosh et al.   Molecular Metabolism

Role of Nitric Oxide in Insulin Secretion and Glucose Metabolism

(2019) Zahra Bahadoran et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences

(2019) Domenico Sergi et al.   Frontiers in Aging Neuroscience

Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling

(2018) Colin T. Stomberski et al.   ANTIOXIDANTS & REDOX SIGNALING

ProteinS-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation StateNovelty and Significance

(2018) Sheng-Bing Wang et al.   CIRCULATION RESEARCH

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

(2018) Zhenlong Chen et al.   MOLECULAR BIOLOGY OF THE CELL

A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation

(2018) Divya Seth et al.   MOLECULAR CELL

PTEN: Tumor Suppressor and Metabolic Regulator

(2018) Chien-Yu Chen et al.   Frontiers in Endocrinology

NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance

(2018) Fernanda Crunfli et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase

(2018) Colin T. Stomberski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury

(2018) Hua-Lin Zhou et al.   NATURE

FoxO integration of insulin signaling with glucose and lipid metabolism

(2017) Sojin Lee et al.   JOURNAL OF ENDOCRINOLOGY

iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents

(2017) Carlos Kiyoshi Katashima et al.   Scientific Reports

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture

(2016) Philipp E. Scherer   DIABETES

To eat, or NOt to eat:S-nitrosylation signaling in autophagy

(2016) Costanza Montagna et al.   FEBS Journal

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

(2016) Wei-Jen Tang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Pro-inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation

(2015) Ruiying Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

S-Nitrosylation of Bcl-2 Negatively Affects Autophagy in Lung Epithelial Cells

(2015) Clayton Wright et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

(2015) Lisa M. DiPilato et al.   MOLECULAR AND CELLULAR BIOLOGY

Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes

(2015) Hirotaka Watada et al.   MOLECULAR ENDOCRINOLOGY

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Targeting endoplasmic reticulum stress in insulin resistance

(2015) Laia Salvadó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress

(2015) Ryosuke Nakato et al.   Scientific Reports

Voluntary Exercise Can Ameliorate Insulin Resistance by Reducing iNOS-Mediated S-Nitrosylation of Akt in the Liver in Obese Rats

(2015) Takamasa Tsuzuki et al.   PLoS One

Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

(2014) E. Lopez-Rivera et al.   CANCER RESEARCH

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Regulation of obesity and insulin resistance by nitric oxide

(2014) Brian E. Sansbury et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models

(2014) M. S. Choi et al.   JOURNAL OF NEUROSCIENCE

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

(2014) Chikako ARAI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Partial Deletion of eNOS Gene Causes Hyperinsulinemic State, Unbalance of Cardiac Insulin Signaling Pathways and Coronary Dysfunction Independently of High Fat Diet

(2014) Cecilia Vecoli et al.   PLoS One

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

(2014) S. Shinozaki et al.   Science Signaling

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Single-Nucleotide Variations in Cardiac Arrhythmias: Prospects for Genomics and Proteomics Based Biomarker Discovery and Diagnostics

(2014) Ayman Abunimer et al.   Genes

Nitrosation-Dependent Caveolin 1 Phosphorylation, Ubiquitination, and Degradation and its Association with Idiopathic Pulmonary Arterial Hypertension

(2014) Farnaz R. Bakhshi et al.   Pulmonary Circulation

Nitric Oxide Directly Promotes Vascular Endothelial Insulin Transport

(2013) H. Wang et al.   DIABETES

Dual Role of Nitric Oxide in Pancreatic β-Cells

(2013) Yukiko Kurohane Kaneko et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Autophagy in Human Health and Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Role of insulin resistance in endothelial dysfunction

(2013) Ranganath Muniyappa et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response

(2013) Robert R.H. Anholt et al.   TRENDS IN MOLECULAR MEDICINE

What causes the insulin resistance underlying obesity?

(2013) Olga T. Hardy et al.   Current Opinion in Endocrinology Diabetes and Obesity

Glucose-stimulated insulin secretion: A newer perspective

(2013) Mitsuhisa Komatsu et al.   Journal of Diabetes Investigation

SnapShot: Physiology of Insulin Signaling

(2012) Takashi Kadowaki et al.   CELL

Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice

(2012) E. R. Ropelle et al.   DIABETES

Pancreatic β-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes

(2012) S. J. Muhammed et al.   DIABETES OBESITY & METABOLISM

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Association with Nitric Oxide Synthase on Insulin Secretory Granules Regulates Glucokinase Protein Levels

(2012) Michele L. Markwardt et al.   MOLECULAR ENDOCRINOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis

(2012) Haruo Kasai et al.   PHYSIOLOGICAL REVIEWS

Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature

(2011) Eugene J. Barrett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF)

(2011) Chunxia Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein folding stress in neurodegenerative diseases: a glimpse into the ER

(2011) Soledad Matus et al.   CURRENT OPINION IN CELL BIOLOGY

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Thioredoxin Increases Exocytosis by DenitrosylatingN-Ethylmaleimide-sensitive Factor

(2011) Takashi Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon-like Peptide 1 Stimulates Post-translational Activation of Glucokinase in Pancreatic β Cells

(2011) Shi-Ying Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased AdipocyteS-Nitrosylation Targets Anti-lipolytic Action of Insulin

(2011) Hilla Ovadia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver-specific Inducible Nitric-oxide Synthase Expression Is Sufficient to Cause Hepatic Insulin Resistance and Mild Hyperglycemia in Mice

(2011) Shohei Shinozaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulus-inducedS-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis

(2011) Dean A. Wiseman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

(2011) N. Numajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Caveolin-1 is required for vascular endothelial insulin uptake

(2010) Hong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4

(2010) Jenna L. Jewell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Enhancement of Insulin Responsiveness by Nitric Oxide-mediated Inactivation of Protein-tyrosine Phosphatases

(2010) Ming-Fo Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

(2010) Young-Don Kwak et al.   Molecular Neurodegeneration

Expression and Regulation of Cyclic Nucleotide Phosphodiesterases in Human and Rat Pancreatic Islets

(2010) Emilia Heimann et al.   PLoS One

POST-BURN HEPATIC INSULIN RESISTANCE IS ASSOCIATED WITH ENDOPLASMIC RETICULUM (ER) STRESS

(2010) Gerd G. Gauglitz et al.   SHOCK

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

Endoplasmic reticulum stress in β-cells and development of diabetes

(2009) Sonya G Fonseca et al.   CURRENT OPINION IN PHARMACOLOGY

Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt

(2009) M. A. Carvalho-Filho et al.   DIABETOLOGIA

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Protective Role of Cys-178 against the Inactivation and Oligomerization of Human Insulin-degrading Enzyme by Oxidation and Nitrosylation

(2009) Luis A. Ralat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Occurring Glucokinase Mutations Are Associated with Defects in Posttranslational S-Nitrosylation

(2009) Shi-Ying Ding et al.   MOLECULAR ENDOCRINOLOGY

Nitric Oxide Activates ATP-Sensitive Potassium Channels in Mammalian Sensory Neurons: Action by Direct S-Nitrosylation

(2009) Takashi Kawano et al.   Molecular Pain

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

S-nitrosylation of PTEN Invovled in Ischemic Brain Injury in Rat Hippocampal CA1 Region

(2009) Dong-Sheng Pei et al.   NEUROCHEMICAL RESEARCH

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

S-nitrosylation of syntaxin 1 at Cys145is a regulatory switch controlling Munc18-1 binding

(2008) Zoë J. Palmer et al.   BIOCHEMICAL JOURNAL

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

(2008) Crystal M. Cordes et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of the Cardiac Muscle Ryanodine Receptor by O2Tension andS-Nitrosoglutathione†

(2008) Junhui Sun et al.   BIOCHEMISTRY

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic β-Cells

(2008) Liling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CysteineS-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation

(2008) Yi-Yun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator

(2008) J. Aittoniemi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Acute physical exercise reversesS-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats

(2007) José R. Pauli et al.   JOURNAL OF PHYSIOLOGY-LONDON