Research progress on the role of cationic amino acid transporter (CAT) family members in malignant tumors and immune microenvironment

Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC

(2023) Shanshan Jiang et al.   Cell Communication and Signaling

Arginase 1 is a key driver of immune suppression in pancreatic cancer

(2023) Rosa Elena Menjivar et al.   eLife

Novel Immune-Related Gene Signature for Risk Stratification and Prognosis of Survival in ER (+) and/or PR (+) and HER2 (−) Breast Cancer

(2022) Feng Du et al.   Frontiers in Pharmacology

Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction

(2022) Kimberlee P. Giffen et al.   Science Advances

A comprehensive analysis of the diagnostic and prognostic value associated with the SLC7A family members in breast cancer

(2022) Liping Yan et al.   Gland Surgery

GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

(2022) Rindert Missiaen et al.   Cell Metabolism

Methylation related genes are associated with prognosis of patients with head and neck squamous cell carcinoma via altering tumor immune microenvironment

(2022) Xudong Tian et al.   Journal of Dental Sciences

Arginase-1 targeting peptide vaccine in patients with metastatic solid tumors – A phase I trial

(2022) Cathrine Lund Lorentzen et al.   Frontiers in Immunology

SLC7A1 Overexpression Is Involved in Energy Metabolism Reprogramming to Induce Tumor Progression in Epithelial Ovarian Cancer and Is Associated with Immune-Infiltrating Cells

(2022) Shijing You et al.   Journal of Oncology

Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles

(2022) Ke Tang et al.   NATURE IMMUNOLOGY

Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis

(2022) Yuhan Yan et al.   Scientific Reports

A novel prognostic model for prostate cancer based on androgen biosynthetic and catabolic pathways

(2022) Aoyu Fan et al.   Frontiers in Oncology

In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

(2021) Hongling Huang et al.   CELL

Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer

(2021) Wangang Gong et al.   Translational Cancer Research

SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells

(2021) Suhong Xia et al.   Cell Death & Disease

Arginine Signaling and Cancer Metabolism

(2021) Chia-Lin Chen et al.   Cancers

The Identification of the Metabolism Subtypes of Skin Cutaneous Melanoma Associated With the Tumor Microenvironment and the Immunotherapy

(2021) Ronghua Yang et al.   Frontiers in Cell and Developmental Biology

A phase 1 study of pegylated recombinant arginase (PEG-BCT-100) in combination with systemic chemotherapy (capecitabine and oxaliplatin)[PACOX] in advanced hepatocellular carcinoma patients

(2021) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

(2020) Dominic G. Roy et al.   Cell Metabolism

Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type

(2020) Jennifer X Ji et al.   CLINICAL CANCER RESEARCH

SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer

(2020) Tianshui Sun et al.   Aging-US

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression

(2020) Weijing He et al.   Molecular Therapy-Oncolytics

Antitumor effects of novel mAbs against cationic amino acid transporter 1 (CAT1) on human CRC with amplified CAT1 gene

(2020) Kouki Okita et al.   CANCER SCIENCE

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

(2019) Xazmin H. Lowman et al.   Cell Reports

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent

(2019) Ghenwa Nasreddine et al.   INVESTIGATIONAL NEW DRUGS

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

(2019) Mark A. Eckert et al.   NATURE

Advances and Challenges in Rational Drug Design for SLCs

(2019) Rachel-Ann A. Garibsingh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

(2019) Maria Esperanza Rodriguez-Ruiz et al.   OncoImmunology

Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion

(2019) Houssam Al-Koussa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability

(2019) Anke Werner et al.   Frontiers in Oncology

CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection

(2019) Lanlan Bai et al.   FASEB JOURNAL

Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma

(2018) G K Abou-Alfa et al.   ANNALS OF ONCOLOGY

Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis

(2018) Lori A. Coburn et al.   ONCOGENE

Elobixibat for the treatment of constipation

(2018) Victor Chedid et al.   Expert Review of Gastroenterology & Hepatology

Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma

(2018) Lei Shen et al.   World Journal of Surgical Oncology

Metabolic pathways of L-arginine and therapeutic consequences in tumors

(2018) Jarosław Szefel et al.   Advances in Medical Sciences

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration

(2017) Elena Brin et al.   Oncotarget

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Molecular basis and current strategies of therapeutic arginine depletion for cancer

(2016) Livingstone Fultang et al.   INTERNATIONAL JOURNAL OF CANCER

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

(2015) F. Mussai et al.   BLOOD

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo

(2015) F. Miraki-Moud et al.   BLOOD

Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation

(2015) Anke Werner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity

(2015) C. Cimen Bozkus et al.   JOURNAL OF IMMUNOLOGY

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

(2015) Oula Khoury et al.   JOURNAL OF NEURO-ONCOLOGY

T cell metabolic fitness in antitumor immunity

(2015) Peter J. Siska et al.   TRENDS IN IMMUNOLOGY

Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine

(2015) Takahiro Kishikawa et al.   Oncotarget

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

SLC7A14 linked to autosomal recessive retinitis pigmentosa

(2014) Zi-Bing Jin et al.   Nature Communications

Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines

(2013) Radosław Januchowski et al.   BIOMEDICINE & PHARMACOTHERAPY

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

(2013) David Vasquez-Dunddel et al.   JOURNAL OF CLINICAL INVESTIGATION

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

(2013) Rita Tanios et al.   LEUKEMIA RESEARCH

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase

(2012) L G Feun et al.   BRITISH JOURNAL OF CANCER

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

(2012) B Delage et al.   Cell Death & Disease

Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

(2011) Vaidehi Agrawal et al.   ANTI-CANCER DRUGS

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

(2011) M P Kelly et al.   BRITISH JOURNAL OF CANCER

CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines

(2011) Salma A. Abdelmagid et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest

(2009) T.L. Lam et al.   CANCER LETTERS

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase

(2008) Tawnya L. Bowles et al.   INTERNATIONAL JOURNAL OF CANCER