Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

(2016) Gregory R Bean et al.   Cell Death & Disease

The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma

(2015) Chen Lin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

(2015) Oula Khoury et al.   JOURNAL OF NEURO-ONCOLOGY

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF)

(2015) Amira Bekdash et al.   Translational Oncology

Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells

(2014) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

(2014) Chun A. Changou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineered Human Arginase I with Enhanced Activity and Stability Controls Hepatocellular and Pancreatic Carcinoma Xenografts

(2014) Evan S. Glazer et al.   Translational Oncology

Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity

(2014) Elias Kassab et al.   Translational Oncology

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

(2013) Rita Tanios et al.   LEUKEMIA RESEARCH

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

(2013) N Syed et al.   Cell Death & Disease

Inhibition of autophagy impairs tumor cell invasion in an organotypic model

(2012) Robin L. Macintosh et al.   CELL CYCLE

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

(2012) B Delage et al.   Cell Death & Disease

Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

(2011) Vaidehi Agrawal et al.   ANTI-CANCER DRUGS

Replacing Mn2+with Co2+in Human Arginase I Enhances Cytotoxicity towardl-Arginine Auxotrophic Cancer Cell Lines

(2010) Everett M. Stone et al.   ACS Chemical Biology

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy

(2010) Ning Zhang et al.   Autophagy

Pegylated arginase I: a potential therapeutic approach in T-ALL

(2010) C. P. Hernandez et al.   BLOOD

The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma

(2010) Suzanne M. Cloonan et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest

(2009) T.L. Lam et al.   CANCER LETTERS

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH