GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Disease Primers

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

(2021) Valerie J. Carpenter et al.   Cancers

The context-specific roles of urea cycle enzymes in tumorigenesis

(2021) Emma Hajaj et al.   MOLECULAR CELL

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

(2021) Sanika Khare et al.   Cancer & Metabolism

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

(2020) Fuming Li et al.   NATURE CELL BIOLOGY

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Protein Synthesis in Colorectal Cancer

(2020) Stefanie Schmidt et al.   Cancers

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

(2019) Laura D. Gamble et al.   Science Translational Medicine

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis

(2019) Le Li et al.   NATURE

Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK

(2019) Hong Ri Jin et al.   Cell Death & Disease

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions

(2019) Abel Soto-Gamez et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii

(2019) Leonardo Augusto et al.   PLoS Pathogens

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode

(2019) Jun Fujimoto et al.   ACS Medicinal Chemistry Letters

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis

(2019) Peiwei Huangyang et al.   Cell Metabolism

Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability

(2019) Anke Werner et al.   Frontiers in Oncology

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

(2019) Marie Jo Halaby et al.   Science Immunology

Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma

(2018) G K Abou-Alfa et al.   ANNALS OF ONCOLOGY

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity

(2018) Joshua D. Ochocki et al.   Cell Metabolism

Strategies targeting cellular senescence

(2018) Yossi Ovadya et al.   JOURNAL OF CLINICAL INVESTIGATION

Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

(2018) Ádám Nagy et al.   Scientific Reports

Recombinant human arginase induces apoptosis via oxidative stress and cell cycle arrest in small cell lung cancer

(2018) Shi Xu et al.   CANCER SCIENCE

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

(2018) Rom Keshet et al.   Disease Models & Mechanisms

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

(2018) Akito Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

(2018) Lea Lough et al.   Computational and Structural Biotechnology Journal

Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma

(2018) Otília Menyhárt et al.   Royal Society Open Science

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

(2017) Jiyeon Kim et al.   NATURE

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma

(2017) Qingqing Liu et al.   PLoS One

Activation of Gcn2 in response to different stresses

(2017) Silje Anda et al.   PLoS One

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Autophagy: a decisive process for stemness

(2016) Laura García-Prat et al.   Oncotarget

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

(2016) Julien Averous et al.   Scientific Reports

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

HIF2 -Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

(2015) B. Qiu et al.   Cancer Discovery

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

(2015) Stacey L. Lehman et al.   PLoS Genetics

Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

(2014) E. Lopez-Rivera et al.   CANCER RESEARCH

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Nitric Oxide Production Upregulates Wnt/ -Catenin Signaling by Inhibiting Dickkopf-1

(2013) Q. Du et al.   CANCER RESEARCH

Overexpression of Arginine Transporter CAT-1 Is Associated with Accumulation of L-Arginine and Cell Growth in Human Colorectal Cancer Tissue

(2013) Ying Lu et al.   PLoS One

DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma

(2011) Hongyan Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting methionine auxotrophy in cancer: discovery & exploration

(2011) Vaidehi Agrawal et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The mechanisms by which polyamines accelerate tumor spread

(2011) Kuniyasu Soda   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

(2010) Wojciech Strzalka et al.   ANNALS OF BOTANY

Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest

(2009) T.L. Lam et al.   CANCER LETTERS