Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

KESTREL and KITE: 52-week results from two Phase III pivotal trials of brolucizumab for diabetic macular edema

(2022) David M. Brown et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Subfoveal choroidal thickness after brolucizumab therapy for neovascular age-related macular degeneration: a short-term multicenter study

(2022) Tamaki Tamashiro et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials

(2022) Jeffrey S Heier et al.   LANCET

Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials

(2022) Charles C Wykoff et al.   LANCET

Association of Pegcetacoplan With Progression of Incomplete Retinal Pigment Epithelium and Outer Retinal Atrophy in Age-Related Macular Degeneration

(2022) Muneeswar Gupta Nittala et al.   JAMA Ophthalmology

New frontiers of retinal therapeutic intervention: a critical analysis of novel approaches

(2022) Onnisa Nanegrungsunk et al.   ANNALS OF MEDICINE

Complications of intravitreal injections: 2022

(2022) Dillan Patel et al.   CURRENT OPINION IN OPHTHALMOLOGY

The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery

(2022) Shrirang V. Ranade et al.   DRUG DELIVERY

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

(2022) Michelle E. McClements et al.   Translational Vision Science & Technology

Ocular Barriers and Their Influence on Gene Therapy Products Delivery

(2022) Bastien Leclercq et al.   Pharmaceutics

Dexamethasone Intravitreal Implant for the Treatment of Macular Edema and Uveitis: A Comprehensive Narrative Review

(2022) Kamal Kishore et al.   Clinical Ophthalmology

Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity

(2022) Andreas Stahl et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

(2022) Camilla Hald Albertsen et al.   ADVANCED DRUG DELIVERY REVIEWS

Intraocular RGD-Engineered Exosomes and Active Targeting of Choroidal Neovascularization (CNV)

(2022) Dimitrios Pollalis et al.   Cells

Management of Key Ocular Adverse Events in Patients Implanted with the Port Delivery System with Ranibizumab

(2022) Carl C. Awh et al.   Ophthalmology Retina

A review of nanocarrier mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances

(2021) Rui Wang et al.   JOURNAL OF DRUG TARGETING

Update on Gene Therapy Clinical Trials for Choroideremia and Potential Experimental Therapies

(2021) Alessandro Abbouda et al.   Medicina-Lithuania

Characterizing New-Onset Exudation in the Randomized Phase 2 FILLY Trial of Complement Inhibitor Pegcetacoplan for Geographic Atrophy

(2021) Charles C. Wykoff et al.   OPHTHALMOLOGY

Durability of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease

(2021) Albert M. Maguire et al.   OPHTHALMOLOGY

Partial recovery of visual function in a blind patient after optogenetic therapy

(2021) José-Alain Sahel et al.   NATURE MEDICINE

Vascular Endothelial Growth Factor Antagonists: Promising Players in the Treatment of Neovascular Age-Related Macular Degeneration

(2021) Rehan M Hussain et al.   Drug Design Development and Therapy

Drug Delivery via the Suprachoroidal Space for the Treatment of Retinal Diseases

(2021) Liron Naftali Ben Haim et al.   Pharmaceutics

Gene therapy for inherited retinal diseases

(2021) Yan Nuzbrokh et al.   Annals of Translational Medicine

Archway Randomized Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration

(2021) Nancy M. Holekamp et al.   OPHTHALMOLOGY

Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR

(2020) Jasmina Cehajic-Kapetanovic et al.   NATURE MEDICINE

Brolucizumab: Evolution through Preclinical and Clinical Studies and the Implications for the Management of Neovascular Age-Related Macular Degeneration

(2020) Quan Dong Nguyen et al.   OPHTHALMOLOGY

Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice

(2020) Koji M. Nishiguchi et al.   Nature Communications

Five-Year Outcomes after Initial Aflibercept, Bevacizumab, or Ranibizumab Treatment for Diabetic Macular Edema (Protocol T Extension Study)

(2020) Adam R. Glassman et al.   OPHTHALMOLOGY

Retinal vasculitis and intraocular inflammation after intravitreal injection of brolucizumab

(2020) Caroline R. Baumal et al.   OPHTHALMOLOGY

HAWK and HARRIER

(2020) Pravin U. Dugel et al.   OPHTHALMOLOGY

Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex

(2020) Hidenori Watanabe et al.   Nature Communications

HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration

(2020) Sunao Sugita et al.   Journal of Clinical Medicine

A comprehensive review on polymeric hydrogel and its composite: Matrices of choice for bone and cartilage tissue engineering

(2020) Huong D.N. Tran et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion–Related Events with Brolucizumab

(2020) Jordi Monés et al.   OPHTHALMOLOGY

Self-assembled poly(ethylene glycol) methyl ether-grafted gelatin nanogels for efficient delivery of curcumin in cancer treatment

(2019) Diem-Huong Nguyen Tran et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Update in treatment of uveitic macular edema

(2019) Spyridon Koronis et al.   Drug Design Development and Therapy

Strategies, design, and chemistry in siRNA delivery systems

(2019) Yizhou Dong et al.   ADVANCED DRUG DELIVERY REVIEWS

An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

(2019) Mohamed F. Attia et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration

(2019) Peter A. Campochiaro et al.   OPHTHALMOLOGY

A multilayered sheet-type device capable of sustained drug release and deployment control

(2019) Yuto Sato et al.   BIOMEDICAL MICRODEVICES

Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation–Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials

(2019) Albert M. Maguire et al.   OPHTHALMOLOGY

Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration.

(2019) David S. Liao et al.   OPHTHALMOLOGY

Abicipar pegol: the non-monoclonal antibody anti-VEGF

(2019) Ashish Sharma et al.   EYE

Ocular inflammatory response to intravitreal injection of AAV vector: relative contribution of genome and capsid

(2019) Adrian Timmers et al.   HUMAN GENE THERAPY

Transscleral sustained ranibizumab delivery using an episcleral implantable device: Suppression of laser-induced choroidal neovascularization in rats

(2019) Nobuhiro Nagai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial

(2019) Andreas Stahl et al.   LANCET

Retinal Vein Occlusions Preferred Practice Pattern®

(2019) Christina J. Flaxel et al.   OPHTHALMOLOGY

Age-Related Macular Degeneration Preferred Practice Pattern®

(2019) Christina J. Flaxel et al.   OPHTHALMOLOGY

Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia

(2019) M. Dominik Fischer et al.   JAMA Ophthalmology

Safety of systemic therapy for noninfectious uveitis

(2019) Maria Soledad Ormaechea et al.   Expert Opinion On Drug Safety

Drug delivery devices for retinal diseases

(2018) Hirokazu Kaji et al.   ADVANCED DRUG DELIVERY REVIEWS

Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population

(2018) Emma Connolly et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Clinical pharmacology of intravitreal anti-VEGF drugs

(2018) Stefano Fogli et al.   EYE

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

(2018) Lyndon da Cruz et al.   NATURE BIOTECHNOLOGY

Choroideremia Gene Therapy Phase 2 Clinical Trial: 24-Month Results

(2018) Byron L. Lam et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application

(2018) Cheng-Han Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models

(2018) Kalyan Dulla et al.   Molecular Therapy-Nucleic Acids

Microneedles: A smart approach and increasing potential for transdermal drug delivery system

(2018) Tejashree Waghule et al.   BIOMEDICINE & PHARMACOTHERAPY

Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief

(2018) Hsin-Yi Huang et al.   International Journal of Nanomedicine

Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2

(2018) Emily Y. Chew et al.   OPHTHALMOLOGY

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

(2018) Karis Little et al.   EBioMedicine

Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery

(2017) Serena G Giannelli et al.   HUMAN MOLECULAR GENETICS

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial

(2017) Pravin U. Dugel et al.   OPHTHALMOLOGY

Pharmacokinetic aspects of retinal drug delivery

(2017) Eva M. del Amo et al.   PROGRESS IN RETINAL AND EYE RESEARCH

PERMEABILITY AND ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR EFFECTS OF BEVACIZUMAB, RANIBIZUMAB, AND AFLIBERCEPT IN POLARIZED RETINAL PIGMENT EPITHELIAL LAYER IN VITRO

(2017) Naoya Yoshihara et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

(2017) Seth R Flaxman et al.   Lancet Global Health

Feasibility of drug delivery to the eye's posterior segment by topical instillation of PLGA nanoparticles

(2017) Kohei Tahara et al.   Asian Journal of Pharmaceutical Sciences

Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8

(2016) Hanen Khabou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of polymeric micelles for targeting intractable cancers

(2016) Nobuhiro Nishiyama et al.   CANCER SCIENCE

Study of stability and biophysical characterization of ranibizumab and aflibercept

(2016) M.R. Moreno et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial

(2016) Quan Dong Nguyen et al.   LANCET

Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

(2016) Jean Bennett et al.   LANCET

Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release

(2016) Tatu Lajunen et al.   MOLECULAR PHARMACEUTICS

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

Adalimumab in Patients with Active Noninfectious Uveitis

(2016) Glenn J. Jaffe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Visual Acuity after Retinal Gene Therapy for Choroideremia

(2016) Thomas L. Edwards et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intravitreal Aflibercept for Diabetic Macular Edema

(2016) Jeffrey S. Heier et al.   OPHTHALMOLOGY

Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study)

(2016) Steffen Schmitz-Valckenberg et al.   OPHTHALMOLOGY

Illegitimate translation causes unexpected gene expression from on-target out-of-frame alleles created by CRISPR-Cas9

(2016) Shigeru Makino et al.   Scientific Reports

CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa

(2015) Daniel M Lipinski et al.   MOLECULAR THERAPY

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis

(2015) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

The REVEAL Study

(2015) Tatsuro Ishibashi et al.   OPHTHALMOLOGY

Intravitreal Aflibercept for Macular Edema Following Branch Retinal Vein Occlusion

(2015) Peter A. Campochiaro et al.   OPHTHALMOLOGY

PENETRATION OF BEVACIZUMAB AND RANIBIZUMAB THROUGH RETINAL PIGMENT EPITHELIAL LAYER IN VITRO

(2015) Hiroto Terasaki et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

INTRAVITREAL CORTICOSTEROIDS IN DIABETIC MACULAR EDEMA

(2015) Yit Yang et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Extent of Exacerbation of Chronic Health Conditions by Visual Impairment in Terms of Health-Related Quality of Life

(2015) Sang Jun Park et al.   JAMA Ophthalmology

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Drug Discovery by NanoMedicine and its Clinical Experience

(2014) Yasuhiro Matsumura   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

(2014) Robert E MacLaren et al.   LANCET

Intravitreal Aflibercept for Diabetic Macular Edema

(2014) Jean-François Korobelnik et al.   OPHTHALMOLOGY

Periocular Corticosteroid Injections in Uveitis

(2014) H. Nida Sen et al.   OPHTHALMOLOGY

Intravitreal Aflibercept Injection for Macular Edema Due to Central Retinal Vein Occlusion

(2014) Jeffrey S. Heier et al.   OPHTHALMOLOGY

Cardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies

(2014) Marie Thulliez et al.   JAMA Ophthalmology

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Randomized Trial of Ciliary Neurotrophic Factor Delivered by Encapsulated Cell Intraocular Implants for Retinitis Pigmentosa

(2013) David G. Birch et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6-month results of the phase III GALILEO study

(2013) Frank G Holz et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Fluocinolone Acetonide Intravitreal Implant (Iluvien®)

(2013) Mark Sanford   DRUGS

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach

(2013) F M Mowat et al.   GENE THERAPY

Light-Activated, In Situ Forming Gel for Sustained Suprachoroidal Delivery of Bevacizumab

(2013) Puneet Tyagi et al.   MOLECULAR PHARMACEUTICS

Intravitreal Aflibercept Injection for Neovascular Age-related Macular Degeneration

(2013) Ursula Schmidt-Erfurth et al.   OPHTHALMOLOGY

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

(2013) Ingeborg Klaassen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Incidence of Legal Blindness From Age-Related Macular Degeneration in Denmark: Year 2000 to 2010

(2012) Sara Brandi Bloch et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab

(2012) Nicholas Papadopoulos et al.   ANGIOGENESIS

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Vascular Endothelial Growth Factor Trap-Eye for Macular Edema Secondary to Central Retinal Vein Occlusion

(2012) David Boyer et al.   OPHTHALMOLOGY

Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration

(2012) Jeffrey S. Heier et al.   OPHTHALMOLOGY

Acute Intraocular Inflammation Caused by Endotoxin after Intravitreal Injection of Counterfeit Bevacizumab in Shanghai, China

(2012) Fenghua Wang et al.   OPHTHALMOLOGY

Prediction of the Vitreal Half-Life of Small Molecular Drug-Like Compounds

(2012) Heidi Kidron et al.   PHARMACEUTICAL RESEARCH

Periocular Triamcinolone Acetonide Injections for Cystoid Macular Edema Complicating Noninfectious Uveitis

(2011) Henry A. Leder et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A Free Retinal Pigment Epithelium–Choroid Graft in Patients With Exudative Age-Related Macular Degeneration: Results up to 7 Years

(2011) Elsbeth J.T. van Zeeburg et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood–retinal barrier

(2011) Ken-ichi Hosoya et al.   Expert Opinion on Drug Delivery

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity

(2011) Helen A. Mintz-Hittner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Sustained Benefits from Ranibizumab for Macular Edema following Central Retinal Vein Occlusion: Twelve-Month Outcomes of a Phase III Study

(2011) Peter A. Campochiaro et al.   OPHTHALMOLOGY

The RESTORE Study

(2011) Paul Mitchell et al.   OPHTHALMOLOGY

Ab-Externo AAV-Mediated Gene Delivery to the Suprachoroidal Space Using a 250 Micron Flexible Microcatheter

(2011) Marc C. Peden et al.   PLoS One

Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration

(2011) K. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency

(2010) J Pang et al.   GENE THERAPY

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Ranibizumab for Macular Edema following Branch Retinal Vein Occlusion

(2010) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Severe Intraocular Inflammation after Intravitreal Injection of Bevacizumab

(2010) Tatsuhiko Sato et al.   OPHTHALMOLOGY

Ranibizumab for Macular Edema following Central Retinal Vein Occlusion

(2010) David M. Brown et al.   OPHTHALMOLOGY

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats

(2009) Hiroshi Tomita et al.   EXPERIMENTAL EYE RESEARCH

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells

(2009) Shozo Sonoda et al.   Nature Protocols

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

(2008) William W. Hauswirth et al.   HUMAN GENE THERAPY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-efficacy site-directed drug delivery system using sialyl-Lewis X conjugated liposome

(2007) Noriyasu Hashida et al.   EXPERIMENTAL EYE RESEARCH