Illegitimate translation causes unexpected gene expression from on-target out-of-frame alleles created by CRISPR-Cas9

Upstream ORFs are prevalent translational repressors in vertebrates

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Analysis of human upstream open reading frames and impact on gene expression

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T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor

(2015) Shigeru Makino et al.   PLoS One

Genome editing at the crossroads of delivery, specificity, and fidelity

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The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

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Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

A guide to genome engineering with programmable nucleases

(2014) Hyongbum Kim et al.   NATURE REVIEWS GENETICS

The regulatory potential of upstream open reading frames in eukaryotic gene expression

(2014) Klaus Wethmar   Wiley Interdisciplinary Reviews-RNA

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

Genome engineering using the CRISPR-Cas9 system

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

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Gli Proteins in Development and Disease

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Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

(2011) A. G. Hinnebusch   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanism of escape from nonsense-mediated mRNA decay of human  -globin transcripts with nonsense mutations in the first exon

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Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

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A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes

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