An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging

(2016) Benqing Zhou et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures

(2016) Héloïse Ragelle et al.   Expert Opinion on Drug Delivery

Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues

(2016) Le Quang Thao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multifunctional Dendrimer-Entrapped Gold Nanoparticles Modified with RGD Peptide for Targeted Computed Tomography/Magnetic Resonance Dual-Modal Imaging of Tumors

(2015) Qian Chen et al.   ANALYTICAL CHEMISTRY

Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatments

(2015) J. A. Ledermann et al.   ANNALS OF ONCOLOGY

Galactose engineered solid lipid nanoparticles for targeted delivery of doxorubicin

(2015) Ashay Jain et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Proton pump inhibitors for the treatment of cancer in companion animals

(2015) Megan Walsh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Synthesis and characterization of Arabic gum capped gold nanoparticles for tumor-targeted drug delivery

(2015) P. Renuga Devi et al.   MATERIALS LETTERS

Targeting Carbonic Anhydrase IX Activity and Expression

(2015) Brian Mahon et al.   MOLECULES

Cancer nanomedicine: addressing the dark side of the enhanced permeability and retention effect

(2015) Elizabeth Huynh et al.   Nanomedicine

Programmable probiotics for detection of cancer in urine

(2015) Tal Danino et al.   Science Translational Medicine

Biodistribution of X-Ray Iodinated Contrast Agent in Nano-Emulsions Is Controlled by the Chemical Nature of the Oily Core

(2014) Mohamed F. Attia et al.   ACS Nano

Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery

(2014) Meiying Wu et al.   ADVANCED MATERIALS

MSN-Mediated Sequential Vascular-to-Cell Nuclear-Targeted Drug Delivery for Efficient Tumor Regression

(2014) Limin Pan et al.   ADVANCED MATERIALS

Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting

(2014) Yayuan Liu et al.   BIOMATERIALS

Acid-mediated Lipinski’s second rule: application to drug design and targeting in cancer

(2014) Ziad Omran et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The development of site-specific drug delivery nanocarriers based on receptor mediation

(2014) Xueqing Wang et al.   JOURNAL OF CONTROLLED RELEASE

Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

(2014) Sijumon Kunjachan et al.   NANO LETTERS

Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

(2014) Hisataka Kobayashi et al.   Theranostics

Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect

(2013) Chao Wang et al.   ACS Nano

Surface modification of lipid nanocapsules with polysaccharides: From physicochemical characteristics to in vivo aspects

(2013) Samuli Hirsjärvi et al.   Acta Biomaterialia

Tumor vasculature targeting and imaging in living mice with reduced graphene oxide

(2013) Sixiang Shi et al.   BIOMATERIALS

Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles

(2013) Qian Chen et al.   BIOMATERIALS

Altered Glutamine Metabolism and Therapeutic Opportunities for Lung Cancer

(2013) Amr Mohamed et al.   Clinical Lung Cancer

Clinical Nanomedicine: A Solution to the Chemotherapy Conundrum in Pediatric Leukemia Therapy

(2013) V Krishnan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Phase I Study of Folate Immune Therapy (EC90 Vaccine Administered With GPI-0100 Adjuvant Followed by EC17) in Patients With Renal Cell Carcinoma

(2013) Robert J. Amato et al.   JOURNAL OF IMMUNOTHERAPY

Transferrin-tailored solid lipid nanoparticles as vectors for site-specific delivery of temozolomide to brain

(2013) Aviral Jain et al.   JOURNAL OF NANOPARTICLE RESEARCH

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(2013) Myra Barginear et al.   MOLECULAR MEDICINE

Targeted Transferrin-Modified Polymeric Micelles: Enhanced Efficacy in Vitro and in Vivo in Ovarian Carcinoma

(2013) Rupa R. Sawant et al.   MOLECULAR PHARMACEUTICS

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Ligand-targeted liposome design: challenges and fundamental considerations

(2013) Gavin T. Noble et al.   TRENDS IN BIOTECHNOLOGY

Recent trends in the use of lipidic nanoparticles as pharmaceutical carriers for cancer therapy and diagnostics

(2013) Samuel V. Mussi et al.   Journal of Materials Chemistry B

In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene

(2012) Hao Hong et al.   ACS Nano

Direct Observation of Nanoparticle–Cancer Cell Nucleus Interactions

(2012) Duncan Hieu M. Dam et al.   ACS Nano

αVβ3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug

(2012) Nora Graf et al.   ACS Nano

A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas

(2012) Yan Li et al.   BIOMATERIALS

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Paclitaxel loaded nano-aggregates based on pH sensitive polyaspartamide amphiphilic graft copolymers

(2012) Kwangwon Seo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo

(2012) Changyou Zhan et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle therapeutics for prostate cancer treatment

(2012) Vanna Sanna et al.   MATURITAS

Transferrin-Modified c[RGDfK]-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy

(2012) Pengcheng Zhang et al.   MOLECULAR PHARMACEUTICS

Conjugation of Functionalized SPIONs with Transferrin for Targeting and Imaging Brain Glial Tumors in Rat Model

(2012) Weili Jiang et al.   PLoS One

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity

(2012) Joseph G. Reynolds et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Micelle-Based Brain-Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand

(2011) Changyou Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nuclear Targeted Silver Nanospheres Perturb the Cancer Cell Cycle Differently than Those of Nanogold

(2011) Lauren A. Austin et al.   BIOCONJUGATE CHEMISTRY

Plasmonic Imaging of Human Oral Cancer Cell Communities during Programmed Cell Death by Nuclear-Targeting Silver Nanoparticles

(2011) Lauren A. Austin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Estrogen-Anchored pH-Sensitive Liposomes as Nanomodule Designed for Site-Specific Delivery of Doxorubicin in Breast Cancer Therapy

(2011) Shivani R. Paliwal et al.   MOLECULAR PHARMACEUTICS

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor delivery of macromolecular drugs based on the EPR effect

(2010) Vladimir Torchilin   ADVANCED DRUG DELIVERY REVIEWS

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors

(2010) Hai He et al.   BIOMATERIALS

Lipopolythiourea/DNA interaction: A biophysical study

(2010) Teresa Kral et al.   BIOPHYSICAL CHEMISTRY

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung

(2010) Melanie Günther et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Tumoral acidic pH-responsive MPEG-poly(β-amino ester) polymeric micelles for cancer targeting therapy

(2010) Kyung Hyun Min et al.   JOURNAL OF CONTROLLED RELEASE

The Protease-Mediated Nucleus Shuttles of Subnanometer Gold Quantum Dots for Real-Time Monitoring of Apoptotic Cell Death

(2010) Shu-Yi Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nuclear Targeting of Gold Nanoparticles in Cancer Cells Induces DNA Damage, Causing Cytokinesis Arrest and Apoptosis

(2010) Bin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Loop 2 of Ophiophagus hannah Toxin b Binds with Neuronal Nicotinic Acetylcholine Receptors and Enhances Intracranial Drug Delivery

(2010) Changyou Zhan et al.   MOLECULAR PHARMACEUTICS

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Targeting nanoparticles to cancer

(2010) M. Wang et al.   PHARMACOLOGICAL RESEARCH

Endoglin-Targeted Cancer Therapy

(2010) Ben K. Seon et al.   Current Drug Delivery

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

A novel thermosensitive polymer with pH-dependent degradation for drug delivery

(2009) V.K. Garripelli et al.   Acta Biomaterialia

ProLindac™ (AP5346): A review of the development of an HPMA DACH platinum Polymer Therapeutic

(2009) David P Nowotnik et al.   ADVANCED DRUG DELIVERY REVIEWS

Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors

(2009) Kathleen M. McNeeley et al.   BIOMATERIALS

Phase Ib study of NGR–hTNF, a selective vascular targeting agent, administered at low doses in combination with doxorubicin to patients with advanced solid tumours

(2009) V Gregorc et al.   BRITISH JOURNAL OF CANCER

Safety, Pharmacokinetics, and Efficacy of CPX-1 Liposome Injection in Patients with Advanced Solid Tumors

(2009) G. Batist et al.   CLINICAL CANCER RESEARCH

pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles

(2009) Wei Chen et al.   JOURNAL OF CONTROLLED RELEASE

Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells

(2009) Chih-Pin Tsai et al.   JOURNAL OF MATERIALS CHEMISTRY

In Vivo Evaluation of Doxorubicin-Loaded Polymeric Micelles Targeting Folate Receptors and Early Endosomal pH in Drug-Resistant Ovarian Cancer

(2009) Dongin Kim et al.   MOLECULAR PHARMACEUTICS

Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles

(2009) Fang Lu et al.   Small

Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

(2008) Fong-Yu Cheng et al.   BIOMATERIALS

Tumour-targeted nanomedicines: principles and practice

(2008) T Lammers et al.   BRITISH JOURNAL OF CANCER