Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles for Efficient Tumor-Specific Multiplex Gene Editing

Anhydrous calcium phosphate crystals stabilize DNA for dry storage

(2022) Philipp L. Antkowiak et al.   CHEMICAL COMMUNICATIONS

Current applications and future perspective of CRISPR/Cas9 gene editing in cancer

(2022) Si-Wei Wang et al.   Molecular Cancer

Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver

(2022) Cory D. Sago et al.   Nature Biomedical Engineering

Delivery of mRNA for regulating functions of immune cells

(2022) Jia Shi et al.   JOURNAL OF CONTROLLED RELEASE

Multimeric RNAs for efficient RNA-based therapeutics and vaccines

(2022) Dajeong Kim et al.   JOURNAL OF CONTROLLED RELEASE

Nano-vectors for CRISPR/Cas9-mediated genome editing

(2022) Peng Yang et al.   Nano Today

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy

(2022) Di Zhang et al.   Nature Nanotechnology

Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy

(2022) Yan Zou et al.   Science Advances

Boosting solid stability

(2022) Stacey-Lynn Paiva   Nature Reviews Chemistry

Therapeutic in vivo delivery of gene editing agents

(2022) Aditya Raguram et al.   CELL

DNA nanostructures as templates for biomineralization

(2021) Dimitra Athanasiadou et al.   Nature Reviews Chemistry

Density Matching Multi-wavelength Analytical Ultracentrifugation to Measure Drug Loading of Lipid Nanoparticle Formulations

(2021) Amy Henrickson et al.   ACS Nano

Tumor‐Targeting Cholesterol‐Decorated DNA Nanoflowers for Intracellular Ratiometric Aptasensing

(2021) Nayoung Kim et al.   ADVANCED MATERIALS

Viscosity-Regulated Control of RNA Microstructure Fabrication

(2021) Sunghyun Moon et al.   Polymers

Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

(2021) Xiaoyu Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

All‐In‐One Dendrimer‐Based Lipid Nanoparticles Enable Precise HDR‐Mediated Gene Editing In Vivo

(2021) Lukas Farbiak et al.   ADVANCED MATERIALS

Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

(2021) Jing Liu et al.   ADVANCED MATERIALS

Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents

(2021) Changlong Wang et al.   ADVANCED MATERIALS

Together is Better: mRNA Co‐Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co‐Delivery and Protein Expression on the Single Cell Level

(2021) Heyang Zhang et al.   Advanced Science

Nano‐enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion

(2021) Sixuan Wu et al.   Advanced Science

Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns

(2021) Jimin Guo et al.   Nature Biomedical Engineering

The promise and challenge of therapeutic genome editing

(2020) Jennifer A. Doudna   NATURE

Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts

(2020) Fabio D. Steffen et al.   Nature Communications

DNA Framework-Encoded Mineralization of Calcium Phosphate

(2020) Xiaoguo Liu et al.   Chem

Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing

(2020) Hao Tang et al.   ADVANCED DRUG DELIVERY REVIEWS

Aptamer/Peptide‐Functionalized Genome‐Editing System for Effective Immune Restoration through Reversal of PD‐L1‐Mediated Cancer Immunosuppression

(2020) Xiao‐Yan He et al.   ADVANCED MATERIALS

Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer

(2020) You Lu et al.   NATURE MEDICINE

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Multiplexed CRISPR technologies for gene editing and transcriptional regulation

(2020) Nicholas S. McCarty et al.   Nature Communications

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors

(2020) Yuanhuan Yu et al.   Science Advances

A Versatile Nonviral Delivery System for Multiplex Gene‐Editing in the Liver

(2020) Jing Gong et al.   ADVANCED MATERIALS

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bioinspired Fabrication of DNA–Inorganic Hybrid Composites Using Synthetic DNA

(2019) Eunjung Kim et al.   ACS Nano

Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization

(2019) Q. Song et al.   Science Advances

Therapeutic genome editing of triple-negative breast tumors using a noncationic and deformable nanolipogel

(2019) Peng Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational designs of in vivo CRISPR-Cas delivery systems

(2019) Cong-Fei Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Magnesium-Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery

(2018) Haoran Zhao et al.   ACS Applied Materials & Interfaces

Metal-Organic Framework Nanoparticles

(2018) Shunzhi Wang et al.   ADVANCED MATERIALS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

(2018) Felicity Allen et al.   NATURE BIOTECHNOLOGY

Biomimetic mineral self-organization from silica-rich spring waters

(2017) Juan Manuel García-Ruiz et al.   Science Advances

A Multi-RNAi Microsponge Platform for Simultaneous Controlled Delivery of Multiple Small Interfering RNAs

(2015) Young Hoon Roh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

How do metal ions direct ribozyme folding?

(2015) Natalia A. Denesyuk et al.   Nature Chemistry

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Cations in charge: magnesium ions in RNA folding and catalysis

(2012) Jessica C Bowman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

A Stability Concept for Metal Ion Coordination to Single-Stranded Nucleic Acids and Affinities of Individual Sites

(2010) Roland K. O. Sigel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Enzymatic route to preparative-scale synthesis of UDP–GlcNAc/GalNAc, their analogues and GDP–fucose

(2010) Guohui Zhao et al.   Nature Protocols