Multimeric RNAs for efficient RNA-based therapeutics and vaccines

Self-assembled mRNA vaccines

(2021) Jeonghwan Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Viscosity-Regulated Control of RNA Microstructure Fabrication

(2021) Sunghyun Moon et al.   Polymers

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

(2021) Ruklanthi de Alwis et al.   MOLECULAR THERAPY

mRNA delivery via non-viral carriers for biomedical applications

(2021) Qi Shuai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development and Delivery Systems of mRNA Vaccines

(2021) Yongjun Liang et al.   Frontiers in Bioengineering and Biotechnology

Self-assembled small messenger RNA nanospheres for efficient therapeutic apoptin expression and synergistic Gene-Chemotherapy of breast cancer

(2021) Yuxia Tang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Polyplex nanomicelle delivery of self-amplifying RNA vaccine

(2021) Yi-Hao Chang et al.   JOURNAL OF CONTROLLED RELEASE

Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines

(2021) Anna K. Blakney et al.   JOURNAL OF CONTROLLED RELEASE

Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures

(2020) Di Liu et al.   Nature Chemistry

mRNA Transfection-Induced Activation of Primary Human Monocytes and Macrophages: Dependence on Carrier System and Nucleotide Modification

(2020) Hanieh Moradian et al.   Scientific Reports

Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

(2020) Jinbing Xie et al.   ACS Nano

Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes

(2020) Nuphar Veiga et al.   ADVANCED DRUG DELIVERY REVIEWS

Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells

(2020) Xiyu Ke et al.   ACS Applied Materials & Interfaces

Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy

(2020) Hyounkoo Han et al.   JOURNAL OF CONTROLLED RELEASE

Amplifying RNA Vaccine Development

(2020) Deborah H. Fuller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

(2020) Paul F. McKay et al.   Nature Communications

Development of a potent Zika virus vaccine using self-amplifying messenger RNA

(2020) Kate Luisi et al.   Science Advances

A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

(2020) Ya-Nan Zhang et al.   CELL RESEARCH

Self-amplifying RNA vaccines for infectious diseases

(2020) Kristie Bloom et al.   GENE THERAPY

A new generation of vaccines based on alphavirus self-amplifying RNA

(2020) María Cristina Ballesteros-Briones et al.   Current Opinion in Virology

Double Controlled Release of Therapeutic RNA Modules through Injectable DNA–RNA Hybrid Hydrogel

(2020) Sangwoo Han et al.   ACS Applied Materials & Interfaces

Establishment human induced pluripotent stem cell line from idiopathic non-familial Parkinson’s disease patient using self-replicating RNA vector

(2020) Harry Murti et al.   Stem Cell Research

In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation

(2020) Sean Mc Cafferty et al.   MOLECULAR THERAPY

One-Pot Production of RNA Nanoparticles via Automated Processing and Self Assembly

(2019) Daniel L Jasinski et al.   ACS Nano

In vitro evolution of enhanced RNA replicons for immunotherapy

(2019) Yingzhong Li et al.   Scientific Reports

Generation of iPSCs by Nonintegrative RNA-Based Reprogramming Techniques: Benefits of Self-Replicating RNA versus Synthetic mRNA

(2019) Heidrun Steinle et al.   Stem Cells International

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

(2019) Mariane Melo et al.   MOLECULAR THERAPY

Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments

(2019) Ângela Sousa et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

BRC-mediated RNAi targeting of USE1 inhibits tumor growth in vitro and in vivo

(2019) Hyejin Kim et al.   BIOMATERIALS

Self-assembly of tumor-targeting RNA nanoball for carrier-free delivery of therapeutic RNA

(2018) Sangwoo Han et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

Enzymatic Synthesis of Self-assembled Dicer Substrate RNA Nanostructures for Programmable Gene Silencing

(2018) Bora Jang et al.   NANO LETTERS

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

Tapping the RNA world for therapeutics

(2018) Judy Lieberman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Tapping the RNA world for therapeutics

(2018) Judy Lieberman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Size-Controllable Enzymatic Synthesis of Short Hairpin RNA Nanoparticles by Controlling the Rate of RNA Polymerization

(2018) Hyejin Kim et al.   Polymers

Self-assembled RNAi nanoflowers via rolling circle transcription for aptamer-targeted siRNA delivery

(2018) Hui Cheng et al.   Journal of Materials Chemistry B

Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids

(2018) Pavlos C. Englezou et al.   Molecular Therapy-Nucleic Acids

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition

(2018) Lauren Rackley et al.   ADVANCED FUNCTIONAL MATERIALS

Preparation and characterization of lipid nanoparticle/pDNA complexes for STAT3 downregulation and overcoming chemotherapy resistance in lung cancer cells

(2017) Mustafa Kotmakçı et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Poly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption

(2017) Jong Seong Ha et al.   JOURNAL OF CONTROLLED RELEASE

Rolling circle transcription-based polymeric siRNA nanoparticles for tumor-targeted delivery

(2017) Jae Hyeop Lee et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription

(2017) Sangwoo Han et al.   Scientific Reports

Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles

(2017) Sijin Guo et al.   Molecular Therapy-Nucleic Acids

Bubbled RNA-Based Cargo for Boosting RNA Interference

(2017) Hyejin Kim et al.   Advanced Science

RNA biology of disease-associated microsatellite repeat expansions

(2017) Kushal J. Rohilla et al.   Acta Neuropathologica Communications

The Discovery of Rolling Circle Amplification and Rolling Circle Transcription

(2016) Michael G. Mohsen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent progress in development of siRNA delivery vehicles for cancer therapy

(2016) Hyun Jin Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Natural supramolecular protein assemblies

(2016) Bas J. G. E. Pieters et al.   CHEMICAL SOCIETY REVIEWS

Reducible Dimeric Conjugates of Small Internally Segment Interfering RNA for Efficient Gene Silencing

(2016) Cheol Am Hong et al.   MACROMOLECULAR BIOSCIENCE

Controllable self-assembly of RNA dendrimers

(2016) Ashwani Sharma et al.   Nanomedicine-Nanotechnology Biology and Medicine

Programmable RNA microstructures for coordinated delivery of siRNAs

(2016) Jaimie Marie Stewart et al.   Nanoscale

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Nucleic Acid Engineering: RNA Following the Trail of DNA

(2016) Hyejin Kim et al.   ACS Combinatorial Science

Generation of siRNA Nanosheets for Efficient RNA Interference

(2016) Hyejin Kim et al.   Scientific Reports

Self-assembled DNA-Guided RNA Nanovector via Step-wise Dual Enzyme Polymerization (SDEP) for Carrier-free siRNA Delivery

(2016) Yongkuk Park et al.   ACS Biomaterials-Science & Engineering

Self-assembled DNA-Guided RNA Nanovector via Step-wise Dual Enzyme Polymerization (SDEP) for Carrier-free siRNA Delivery

(2016) Yongkuk Park et al.   ACS Biomaterials Science & Engineering

Multivalent aptamer–RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells

(2015) Jihyun Kim et al.   CHEMICAL COMMUNICATIONS

Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy

(2015) Min Ju Kim et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo

(2015) So Jin Lee et al.   JOURNAL OF CONTROLLED RELEASE

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

(2015) Azita J Mahiny et al.   NATURE BIOTECHNOLOGY

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant

(2015) Naoya Miura et al.   NUCLEIC ACIDS RESEARCH

Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription

(2015) Mihue Jang et al.   Nature Communications

Self-assembled Messenger RNA Nanoparticles (mRNA-NPs) for Efficient Gene Expression

(2015) Hyejin Kim et al.   Scientific Reports

RNA Self-Assembly and RNA Nanotechnology

(2014) Wade W. Grabow et al.   ACCOUNTS OF CHEMICAL RESEARCH

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Enzymatic size control of RNA particles using complementary rolling circle transcription (cRCT) method for efficient siRNA production

(2014) Daehoon Han et al.   CHEMICAL COMMUNICATIONS

Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

(2014) Hyundong Yoo et al.   CHEMICAL COMMUNICATIONS

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

(2014) W. M. Bogers et al.   JOURNAL OF INFECTIOUS DISEASES

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

(2014) Emil F. Khisamutdinov et al.   NUCLEIC ACIDS RESEARCH

Self-assembly of free-standing RNA membranes

(2014) Daehoon Han et al.   Nature Communications

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

(2014) Kenneth C McCullough et al.   Molecular Therapy-Nucleic Acids

Self-crosslinked human serum albumin nanocarriers for systemic delivery of polymerized siRNA to tumors

(2013) Sohee Son et al.   BIOMATERIALS

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

(2013) Naohisa Yoshioka et al.   Cell Stem Cell

Biocompatible gelatin nanoparticles for tumor-targeted delivery of polymerized siRNA in tumor-bearing mice

(2013) So Jin Lee et al.   JOURNAL OF CONTROLLED RELEASE

Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format

(2013) Kyle K.L. Phua et al.   JOURNAL OF CONTROLLED RELEASE

Impact of siRNA Overhangs for Dendrimer-Mediated siRNA Delivery and Gene Silencing

(2013) Paola Posocco et al.   MOLECULAR PHARMACEUTICS

Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells

(2013) Yi Shu et al.   Nature Protocols

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

(2013) Armin Hekele et al.   Emerging Microbes & Infections

Small-Interfering RNA (siRNA)-Based Functional Micro- and Nanostructures for Efficient and Selective Gene Silencing

(2012) Soo Hyeon Lee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Regulation of small RNA stability: methylation and beyond

(2012) Lijuan Ji et al.   CELL RESEARCH

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers

(2012) Farzin Haque et al.   Nano Today

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reducible siRNA Dimeric Conjugates for Efficient Cellular Uptake and Gene Silencing

(2011) Hyun Jung Chung et al.   BIOCONJUGATE CHEMISTRY

Nanoparticledrug delivery enhances the cytotoxicity of hydrophobic–hydrophilic drug conjugates

(2011) Santosh Aryal et al.   JOURNAL OF MATERIALS CHEMISTRY

Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation

(2011) Cheol Am Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembling RNA Nanorings Based on RNAI/II Inverse Kissing Complexes

(2011) Wade W. Grabow et al.   NANO LETTERS

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Dual gene targeted multimeric siRNA for combinatorial gene silencing

(2010) Soo Hyeon Lee et al.   BIOMATERIALS

Gold nanoparticle platforms as drug and biomacromolecule delivery systems

(2010) Bradley Duncan et al.   JOURNAL OF CONTROLLED RELEASE

Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing

(2010) Hyejung Mok et al.   NATURE MATERIALS

Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA

(2010) Pradeep S. Pallan et al.   NUCLEIC ACIDS RESEARCH

Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies

(2009) M Jean et al.   GENE THERAPY

Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing

(2009) Seung-Young Lee et al.   JOURNAL OF CONTROLLED RELEASE

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

(2009) D. Uzri et al.   JOURNAL OF VIROLOGY

Square-Shaped RNA Particles from Different RNA Folds

(2009) Isil Severcan et al.   NANO LETTERS

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity

(2009) Paola M. Barral et al.   PHARMACOLOGY & THERAPEUTICS

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

(2009) A. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biodegradable polymers as non-viral carriers for plasmid DNA delivery

(2007) Jordy Luten et al.   JOURNAL OF CONTROLLED RELEASE