Isorhynchophylline inhibits inflammatory responses in endothelial cells and macrophages through the NF-κB/NLRP3 signaling pathway

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

(2021) Huxinyue Duan et al.   PHARMACOLOGICAL RESEARCH

Implications for the role of lipopolysaccharide in the development of atherosclerosis

(2021) Armita Mahdavi Gorabi et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook

(2021) Hirotaka Kushida et al.   Frontiers in Pharmacology

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation

(2020) Xian Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deciphering the Mechanism of the Anti-Hypertensive Effect of Isorhynchophylline by Targeting Neurotransmitters Metabolism of Hypothalamus in Spontaneously Hypertensive Rats

(2020) Yuan Li et al.   ACS Chemical Neuroscience

Novel emerging therapies in atherosclerosis targeting lipid metabolism

(2020) Manasvi Gupta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway

(2020) Shenglong Chen et al.   Frontiers in Immunology

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Isorhynchophylline exerts anti-inflammatory and anti-oxidative activities in LPS-stimulated murine alveolar macrophages

(2019) Zheng Zhou et al.   LIFE SCIENCES

Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3β signaling pathway

(2019) Yan-Fang Xian et al.   FASEB JOURNAL

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF-κB pathway

(2019) Jinyue Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux

(2018) Liang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imaging the Intersection of Oxidative Stress, Lipids, and Inflammation

(2018) Ahmed Tawakol et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages

(2018) Irina Sieve et al.   VASCULAR PHARMACOLOGY

Apoprotein E and Reverse Cholesterol Transport

(2018) Godfrey Getz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Macrophage phenotypes in atherosclerosis

(2014) Sophie Colin et al.   IMMUNOLOGICAL REVIEWS

Endothelial cells and the IGF system

(2014) Leon A Bach   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases

(2012) Ji-Yin Zhou et al.   FITOTERAPIA

Hypercholesterolemia links hematopoiesis with atherosclerosis

(2012) Oliver Soehnlein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism

(2009) Dan Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE