Endothelial cells and the IGF system

Haploinsufficiency of the Insulin-Like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype

(2014) Nadira Y. Yuldasheva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation

(2014) Charlotte Rombouts et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Control of Adipose Tissue Expandability in Response to High Fat Diet by the Insulin-like Growth Factor-binding Protein-4

(2014) Olga Gealekman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells

(2014) Xiaohong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TNFα Inhibits IGFBP-3 through Activation of p38α and Casein Kinase 2 in Human Retinal Endothelial Cells

(2014) Qiuhua Zhang et al.   PLoS One

Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor

(2013) Qiuhua Zhang et al.   APOPTOSIS

Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor

(2013) Y. Pan et al.   JOURNAL OF IMMUNOLOGY

Insulin-like growth factor 1 opposes the effects of C-reactive protein on endothelial cell activation

(2013) Shao-Jun Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium

(2013) V. Kate Gatenby et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of IGF-1R Prevents Ionizing Radiation-Induced Primary Endothelial Cell Senescence

(2013) Ronald Allan M. Panganiban et al.   PLoS One

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

(2012) H. Imrie et al.   DIABETES

Insulin and IGF1 receptors in human cardiac microvascular endothelial cells: metabolic, mitogenic and anti-inflammatory effects

(2012) Karolina Bäck et al.   JOURNAL OF ENDOCRINOLOGY

The importance of the endothelium in atherothrombosis and coronary stenting

(2012) Fumiyuki Otsuka et al.   Nature Reviews Cardiology

Hypoxia-induced insulin-like growth factor II contributes to retinal vascularization in ocular development

(2011) Jin Hyoung Kim et al.   BIOCHIMIE

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

IGF-1 and atherothrombosis: relevance to pathophysiology and therapy

(2011) Elena Conti et al.   CLINICAL SCIENCE

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

(2011) A. Abbas et al.   DIABETES

IGFBP-2 Enhances VEGF Gene Promoter Activity and Consequent Promotion of Angiogenesis by Neuroblastoma Cells

(2011) Walid J. Azar et al.   ENDOCRINOLOGY

Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1

(2011) Brian Hynes et al.   EUROPEAN HEART JOURNAL

IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis

(2011) Chunyang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Potent Inhibition of Angiogenesis by the IGF-1 Receptor-Targeting Antibody SCH717454 Is Reversed by IGF-2

(2011) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

(2010) Kristina Hedbacker et al.   Cell Metabolism

Association of serum IGF1 with endothelial function: results from the population-based study of health in Pomerania

(2010) Klaus Empen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Aerobic exercise acutely improves insulin- and insulin-like growth factor-1-mediated vasorelaxation in hypertensive rats

(2010) Ai-Lun Yang et al.   EXPERIMENTAL PHYSIOLOGY

A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo

(2010) D. T. Dransfield et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-Regulated Angiogenic Inhibitors

(2010) Angela Messmer-Blust et al.   TRENDS IN CARDIOVASCULAR MEDICINE

IGF-1, oxidative stress and atheroprotection

(2010) Yusuke Higashi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation

(2009) Jennifer L. Kielczewski et al.   CIRCULATION RESEARCH

Vascular Insulin-Like Growth Factor-I Resistance and Diet-Induced Obesity

(2009) Helen Imrie et al.   ENDOCRINOLOGY

Increased Intraocular Insulin-like Growth Factor-I Triggers Blood-Retinal Barrier Breakdown

(2009) Virginia Haurigot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury

(2009) A. CITTADINI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Keeping IGF-II under control: Lessons from the IGF-II–IGF2R crystal structure

(2009) James Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

(2009) Stephen B. Wheatcroft et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC 2 axis

(2008) Y.-S. Maeng et al.   BLOOD

Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis

(2008) Seung Bae Rho et al.   CARCINOGENESIS

Low-Plasma Insulin-Like Growth Factor-I Levels Are Associated with Impaired Endothelium-Dependent Vasodilatation in a Cohort of Untreated, Hypertensive Caucasian Subjects

(2008) Francesco Perticone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of Insulin-Like Growth Factor Binding Protein-3 in Human Umbilical Vein Endothelial Cell Senescence

(2008) Christoph Muck et al.   REJUVENATION RESEARCH

The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease

(2007) Vivienne A. Ezzat et al.   DIABETES OBESITY & METABOLISM