Origin and segregation of the human germline

Amniogenesis occurs in two independent waves in primates

(2022) Maria Rostovskaya et al.   Cell Stem Cell

Sequential enhancer state remodelling defines human germline competence and specification

(2022) Walfred W. C. Tang et al.   NATURE CELL BIOLOGY

Microgel culture and spatial identity mapping elucidate the signalling requirements for primate epiblast and amnion formation

(2022) Clara Munger et al.   DEVELOPMENT

Spatial profiling of early primate gastrulation in utero

(2022) Sophie Bergmann et al.   NATURE

Single-cell roadmap of human gonadal development

(2022) Luz Garcia-Alonso et al.   NATURE

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

(2021) Qifan Zhu et al.   Cell Reports

GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program

(2021) Yoji Kojima et al.   Life Science Alliance

Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids

(2021) Kyaw Thu Minn et al.   Stem Cell Reports

Conserved features of non-primate bilaminar disc embryos and the germline

(2021) Ramiro Alberio et al.   Stem Cell Reports

Single-cell transcriptomic characterization of a gastrulating human embryo

(2021) Richard C. V. Tyser et al.   NATURE

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

(2021) Luz Garcia-Alonso et al.   NATURE GENETICS

Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells

(2021) Toshihiro Kobayashi et al.   Cell Reports

A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

(2020) Anastasiya Sybirna et al.   Nature Communications

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

(2020) Leqian Yu et al.   Cell Stem Cell

High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

(2020) Kyaw Thu Minn et al.   eLife

A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

(2019) Iain Martyn et al.   DEVELOPMENT

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming

(2019) Geoffrey Schiebinger et al.   CELL

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate

(2019) Sina V. Jostes et al.   INTERNATIONAL JOURNAL OF CANCER

In vitro culture of cynomolgus monkey embryos beyond early gastrulation

(2019) Huaixiao Ma et al.   SCIENCE

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors

(2019) Di Chen et al.   Cell Reports

On the origin of the human germline

(2018) Toshihiro Kobayashi et al.   DEVELOPMENT

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Principles of early human development and germ cell program from conserved model systems

(2017) Toshihiro Kobayashi et al.   NATURE

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency

(2017) Christian Krendl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion

(2016) Kotaro Sasaki et al.   DEVELOPMENTAL CELL

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Specification and epigenetic programming of the human germ line

(2016) Walfred W. C. Tang et al.   NATURE REVIEWS GENETICS

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

(2015) Fan Guo et al.   CELL

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

(2015) Kotaro Sasaki et al.   Cell Stem Cell

Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells

(2014) I-Ying Lin et al.   Stem Cell Reports

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

(2013) Federica Campolo et al.   STEM CELLS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Pluripotency factors regulate definitive endoderm specification through eomesodermin

(2011) A. K. K. Teo et al.   GENES & DEVELOPMENT

Developmental Stages in Human Embryos: Revised and New Measurements

(2010) Ronan O’Rahilly et al.   CELLS TISSUES ORGANS