Specification and epigenetic programming of the human germ line

Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro

(2016) Quan Zhou et al.   Cell Stem Cell

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

(2016) Jyoti Rao et al.   Cell Stem Cell

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory

(2016) William A. Pastor et al.   Cell Stem Cell

Co-repressor CBFA2T2 regulates pluripotency and germline development

(2016) Shengjiang Tu et al.   NATURE

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

(2016) Kazuhiro Murakami et al.   NATURE

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

(2016) Leehee Weinberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

(2016) Marius Walter et al.   eLife

The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

(2015) Fan Guo et al.   CELL

DNA Demethylation Dynamics in the Human Prenatal Germline

(2015) Sofia Gkountela et al.   CELL

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Dynamic Pluripotent Stem Cell States and Their Applications

(2015) Jun Wu et al.   Cell Stem Cell

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

(2015) Kazuki Kurimoto et al.   Cell Stem Cell

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

(2015) Kotaro Sasaki et al.   Cell Stem Cell

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

(2015) P. Blakeley et al.   DEVELOPMENT

Primordial germ cells: the first cell lineage or the last cells standing?

(2015) A. D. Johnson et al.   DEVELOPMENT

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile

(2015) F. Sugawa et al.   EMBO JOURNAL

Molecular insights into transgenerational non-genetic inheritance of acquired behaviours

(2015) Johannes Bohacek et al.   NATURE REVIEWS GENETICS

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo

(2015) Julia Arand et al.   Epigenetics & Chromatin

Discovery and Characterization of piRNAs in the Human Fetal Ovary

(2015) Zev Williams et al.   Cell Reports

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

(2015) Jan J Zylicz et al.   eLife

ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation

(2015) Nataliya Nady et al.   eLife

Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

(2015) Gernot Wolf et al.   Mobile DNA

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Reorganization of Enhancer Patterns in Transition from Naive to Primed Pluripotency

(2014) Christa Buecker et al.   Cell Stem Cell

Regulatory Principles of Pluripotency: From the Ground State Up

(2014) Jamie A. Hackett et al.   Cell Stem Cell

Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos

(2014) J. Chatfield et al.   DEVELOPMENT

Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation

(2014) Griselda Valdez Magaña et al.   DEVELOPMENTAL BIOLOGY

Setdb1is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells

(2014) Sheng Liu et al.   GENES & DEVELOPMENT

DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos

(2014) D. M. Messerschmidt et al.   GENES & DEVELOPMENT

PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

(2014) Shinseog Kim et al.   MOLECULAR CELL

Totipotency and lineage segregation in the human embryo

(2014) C. De Paepe et al.   MOLECULAR HUMAN REPRODUCTION

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

(2014) Frank M. J. Jacobs et al.   NATURE

DNA methylation dynamics of the human preimplantation embryo

(2014) Zachary D. Smith et al.   NATURE

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

(2014) Thorsten Boroviak et al.   NATURE CELL BIOLOGY

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Sall4 Is Essential for Mouse Primordial Germ Cell Specification by Suppressing Somatic Cell Program Genes

(2014) Yasuka L. Yamaguchi et al.   STEM CELLS

New concepts in DNA methylation

(2014) Albert Jeltsch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells

(2014) I-Ying Lin et al.   Stem Cell Reports

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming

(2013) Shinpei Yamaguchi et al.   CELL RESEARCH

PRDM14 Ensures Naive Pluripotency through Dual Regulation of Signaling and Epigenetic Pathways in Mouse Embryonic Stem Cells

(2013) Masashi Yamaji et al.   Cell Stem Cell

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

(2013) Yoji Kojima et al.   Cell Stem Cell

Germ Cell Specification Requires Zygotic Mechanisms Rather Than Germ Plasm in a Basally Branching Insect

(2013) Ben Ewen-Campen et al.   CURRENT BIOLOGY

How to make a primordial germ cell

(2013) E. Magnusdottir et al.   DEVELOPMENT

Sox proteins: regulators of cell fate specification and differentiation

(2013) Y. Kamachi et al.   DEVELOPMENT

A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells

(2013) R. Ohno et al.   DEVELOPMENT

In Vivo Epigenomic Profiling of Germ Cells Reveals Germ Cell Molecular Signatures

(2013) Jia-Hui Ng et al.   DEVELOPMENTAL CELL

A Mesodermal Factor, T, Specifies Mouse Germ Cell Fate by Directly Activating Germline Determinants

(2013) Shinya Aramaki et al.   DEVELOPMENTAL CELL

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

(2013) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

(2013) Irene Aksoy et al.   EMBO JOURNAL

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

(2013) Nils Grabole et al.   EMBO REPORTS

High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice

(2013) H. Kobayashi et al.   GENOME RESEARCH

Role of Tet1 in erasure of genomic imprinting

(2013) Shinpei Yamaguchi et al.   NATURE

Induction of mouse germ-cell fate by transcription factors in vitro

(2013) Fumio Nakaki et al.   NATURE

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

A tripartite transcription factor network regulates primordial germ cell specification in mice

(2013) Erna Magnúsdóttir et al.   NATURE CELL BIOLOGY

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

(2013) Federica Campolo et al.   STEM CELLS

Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency

(2013) Mi-Young Son et al.   STEM CELLS

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice

(2012) Saya Kagiwada et al.   EMBO JOURNAL

Global profiling of DNA methylation erasure in mouse primordial germ cells

(2012) S. Guibert et al.   GENOME RESEARCH

Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

(2012) Arie B. Brinkman et al.   GENOME RESEARCH

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

Tet1 controls meiosis by regulating meiotic gene expression

(2012) Shinpei Yamaguchi et al.   NATURE

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

(2012) Thomas O'Leary et al.   NATURE BIOTECHNOLOGY

The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation

(2012) Sofia Gkountela et al.   NATURE CELL BIOLOGY

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice

(2012) K. Hayashi et al.   SCIENCE

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

(2012) J. A. Hackett et al.   SCIENCE

Parallel mechanisms of epigenetic reprogramming in the germline

(2012) Jamie A. Hackett et al.   TRENDS IN GENETICS

In Vivo Differentiation Potential of Epiblast Stem Cells Revealed by Chimeric Embryo Formation

(2012) Yali Huang et al.   Cell Reports

PRDM proteins: Important players in differentiation and disease

(2011) Cathrine K. Fog et al.   BIOESSAYS

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

(2011) Katsuhiko Hayashi et al.   CELL

Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells

(2011) M. Saitou et al.   DEVELOPMENT

BMP signals and the transcriptional repressor BLIMP1 during germline segregation in the mammalian embryo

(2011) Clas Hopf et al.   DEVELOPMENT GENES AND EVOLUTION

Pax6 Is a Human Neuroectoderm Cell Fate Determinant

(2010) Xiaoqing Zhang et al.   Cell Stem Cell

Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state

(2010) H. G. Leitch et al.   DEVELOPMENT

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

(2010) K. K. Niakan et al.   GENES & DEVELOPMENT

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

(2010) Na-Yu Chia et al.   NATURE

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

(2010) Ziyang Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

(2010) F. Baudat et al.   SCIENCE

Critical Function of AP-2gamma/TCFAP2C in Mouse Embryonic Germ Cell Maintenance1

(2009) Susanne Weber et al.   BIOLOGY OF REPRODUCTION

A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

(2009) Yasuhide Ohinata et al.   CELL

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro

(2009) K. Hayashi et al.   DEVELOPMENT

Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells

(2009) S. Yamaguchi et al.   DEVELOPMENT

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

(2009) J. Rossant et al.   DEVELOPMENT

Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis

(2009) Kenshiro Hara et al.   DEVELOPMENTAL BIOLOGY

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

(2009) Sonia Stefanovic et al.   JOURNAL OF CELL BIOLOGY

Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation

(2009) Kehkooi Kee et al.   NATURE

Regulation and Functions of Blimp-1 in T and B Lymphocytes

(2008) Gislâine Martins et al.   Annual Review of Immunology

PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells

(2008) Norihiro Tsuneyoshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Early Human Germ Cell Lineage Does Not Express SOX2 During In Vivo Development or upon In Vitro Culture1

(2008) Rebecca M. Perrett et al.   BIOLOGY OF REPRODUCTION

Establishment of Endoderm Progenitors by SOX Transcription Factor Expression in Human Embryonic Stem Cells

(2008) Cheryle A. Séguin et al.   Cell Stem Cell

A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints

(2008) Xiajun Li et al.   DEVELOPMENTAL CELL

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

(2008) K. Kurimoto et al.   GENES & DEVELOPMENT

Expression of pluripotent stem cell markers in the human fetal ovary

(2008) C. L. Kerr et al.   HUMAN REPRODUCTION

Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications

(2008) J de Jong et al.   JOURNAL OF PATHOLOGY

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57

(2008) Deborah J G Mackay et al.   NATURE GENETICS

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

(2008) Masashi Yamaji et al.   NATURE GENETICS

X Chromosome Activity in Mouse XX Primordial Germ Cells

(2008) Susana M. Chuva de Sousa Lopes et al.   PLoS Genetics

Reprogramming Primordial Germ Cells into Pluripotent Stem Cells

(2008) Gabriela Durcova-Hills et al.   PLoS One

Expression of Pluripotent Stem Cell Markers in the Human Fetal Testis

(2007) Candace L. Kerr et al.   STEM CELLS