Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

In a mouse model of INCL reduced S‐palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation

(2021) Tamal Sadhukhan et al.   JOURNAL OF INHERITED METABOLIC DISEASE

DHHC5 facilitates oligodendrocyte development by palmitoylating and activating STAT3

(2021) Yanchen Ma et al.   GLIA

Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

(2020) Akriti Kharbanda et al.   Science Signaling

Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase

(2020) Fiona Plain et al.   Communications Biology

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

(2019) Junya Peng et al.   CELL RESEARCH

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

(2019) Yan Lu et al.   SCIENCE

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

(2018) Hong Jiang et al.   CHEMICAL REVIEWS

Fatty acyl recognition and transfer by an integral membraneS-acyltransferase

(2018) Mitra S. Rana et al.   SCIENCE

S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration

(2017) Pornpun Aramsangtienchai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling

(2017) Shaymaa Mohamed Mohamed Badawy et al.   Scientific Reports

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13S-Acyltransferases

(2015) Kimon Lemonidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras moves to stay in place

(2015) Malte Schmick et al.   TRENDS IN CELL BIOLOGY

Phase II clinical trial of pasireotide long-acting repeatable in patients with metastatic neuroendocrine tumors

(2014) M Cives et al.   ENDOCRINE-RELATED CANCER

Targeting protein palmitoylation: selective inhibitors and implications in disease

(2014) Burzin Chavda et al.   Expert Opinion on Drug Discovery

Identification ofZDHHC14as a novel human tumour suppressor gene

(2014) Marc Yeste-Velasco et al.   JOURNAL OF PATHOLOGY

Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity

(2014) G Stefano Brigidi et al.   NATURE NEUROSCIENCE

Emerging roles for protein S-palmitoylation in immunity from chemical proteomics

(2013) Jacob S Yount et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Deciphering post-translational modification codes

(2013) Adam P. Lothrop et al.   FEBS LETTERS

Palmitoylation by DHHC5/8 Targets GRIP1 to Dendritic Endosomes to Regulate AMPA-R Trafficking

(2012) Gareth M. Thomas et al.   NEURON

Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival

(2011) Donghui Li et al.   CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase

(2011) Tarja Kokkola et al.   FEBS LETTERS

DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells

(2011) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

(2011) Jennifer Greaves et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Hypofunctional Effect of P335L Single Nucleotide Polymorphism on SSTR5 Function

(2011) Guisheng Zhou et al.   WORLD JOURNAL OF SURGERY

Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box

(2010) Florian Baumgart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology